Immune protection is achieved by the elaboration of many molecules that together can not only destroy invading organisms, pathogenic cells, and tumors but also injure normal cells. This review series focuses on recent advances indicating that distinct subsets of regulatory T cells and natural killer T cells control potentially pathogenic antigen-reactive T cells. These suppressor cells may play important roles in transplantation, allergic disease, vaccination, and the prevention and treatment of autoimmune disease.
Published November 2004
This series examines six different pathogens in order to illustrate the selective forces that drive the emergence of new infectious diseases and the implications for public health and our survival.
Published March 2004
Cellular life span is restrained by signaling pathways activated by DNA damage, telomere dysfunction, and environmental stresses. Cells entering a state of senescence undergo a permanent cell cycle arrest, and functional and morphological changes. This series investigates the molecular pathways associated with execution of the senescence program and how it contributes to aging and tumor suppression.
Published January 2004
Researchers have only recently realized that bacteria use cell-to-cell communication in order to orchestrate gene expression during infection - a phenomenon known as quorum sensing. This series explores the role of these signaling mechanisms and bacterial group behavior in evading host defenses and antibiotics.
Published November 2003
This series examines the inspired techniques utilized in targeted gene repair for the simple correction of genetic defects and the hurdles that must be overcome in order to make clinical use of molecular therapeutics in the treatment of diseases such as cystic fibrosis, hemophilia, sickle cell anemia, muscular dystrophy, and ß-thalassemia.
Published August 2003
Advances in medical imaging have allowed for further understanding of human diseases. This series covers new developments in imaging from novel techniques to the ethics of whole body scans.
Published May 2003
This series discusses various mechanisms by which oxygen and reducing equivalents create cellular damage and how they have been adapted to transmit information within cells.
Published March 2003
Articles in this series review selected genetic and molecular advances relevant to the biology of neurodegeneration. Readers obtain a comprehensive update on prominent neurodegenerative conditions from both a clinical and a molecular viewpoint.
Published January 2003
This series discusses our current understanding of protein folding and the mechanisms by which disease-associated proteins aggregate, injure cells, and trigger responses designed to protect cells from such injury.
Published November 2002
An essential component of healthy cells, cholesterol in excess is a major culprit of atherosclerosis. This series covers a number of interesting topics related to the physiological and pathophysiological roles of this fascinating molecule.
Published September 2002