This series discusses various mechanisms by which oxygen and reducing equivalents create cellular damage and how they have been adapted to transmit information within cells.
Published March 2003
Articles in this series review selected genetic and molecular advances relevant to the biology of neurodegeneration. Readers obtain a comprehensive update on prominent neurodegenerative conditions from both a clinical and a molecular viewpoint.
Published January 2003
This series discusses our current understanding of protein folding and the mechanisms by which disease-associated proteins aggregate, injure cells, and trigger responses designed to protect cells from such injury.
Published November 2002
An essential component of healthy cells, cholesterol in excess is a major culprit of atherosclerosis. This series covers a number of interesting topics related to the physiological and pathophysiological roles of this fascinating molecule.
Published September 2002
Articles in this series discuss ways to increase vaccine efficiency in general, and review advances and challenges in developing and improving vaccines for bacterial and viral diseases as well as cancer.
Published June 2002
The series provides an overview over the JAK-STAT pathway and explores the important functions it plays in regulating immune responses and cellular homeostasis in human heath and disease.
Published May 2002
Most cancer patients die not from primary tumors but from metastatic disease. Besides the molecular basis for metastasis of human tumors, the series discusses the adhesive cellular interactions that are critical for invasive growth.
Published April 2002
Without extensive defense mechanisms, breathing would be dangerous. This series summarizes the current concepts underlying the biological processes that mediate the intrinsic and innate host defense against microbial invasion of the lung.
Published March 2002
Activation of immune cells must be tightly controlled. Articles in the series outline our current understanding of the delicate balance of positive and negative signals implicated in T cell activation, effector function, and apoptosis, and discuss the most pressing open questions.
Published January 2002
Inflammation and immunity are subject to neuroendocrine effects. The articles explore some of the developmental, physiological, and molecular interactions occurring at the immuno-neuroendocrine interface.
Published December 2001