Jane Salmon, Carl Blobel, Priya Darshinee Issuree, and Thorsten Maretzky of the Weill Cornell University Hospital for Special Surgery discuss the role of iRHOM2 in inflammatory arthritis.
Published January 25, 2013

Bone is a dynamic organ that undergoes continuous remodeling through the action of osteoblasts that create new bone and osteoclasts that resorb old bone. To identify factors that control the...
Published January 16, 2013

SPARC (secreted protein acidic and rich in cysteine) is an extracellular matrix glycoprotein that has been implicated in multiple aspects of human cancer. In bladder cancer, it has been...
Published January 16, 2013

Mutations in the human cathepsin K (CTSK) cause pycnodysostosis, an autosomal recessive disease characterized by short stature and elevated bone density (osteopetrosis). In mice, global...
Published January 16, 2013

Patients with chronic kidney disease (CKD)  frequently suffer from vascular calcification that can cause chronic heart failure. Similar to patients with CKD, mice that lack the FGF23 receptor...
Published January 9, 2013