Posts

507 items found.
Anti-influenza antibody in hemagglutinin head domain interface
In this episode, James Crowe reports a pan-H7 influenza protective human antibody that recognizes an epitope in the hemagglutinin head domain interface and disrupts HA trimers...
Published August 4, 2020
Author's Take
Salt generates antiinflammatory Th17 cells but amplifies pathogenicity
In this episode, Christina Zielinski and Julia Matthias explain that sodium chloride generates anti-inflammatory human Th17 cell responses but is coopted by pro-inflammatory cytokines to amplify Th17 cell pathogenicity and autoimmunity...
Published July 27, 2020
Author's Take
T cells prevent and treat graft-versus-host disease
In this episode, Marco Davila and Brian Betts explain that taking advantage of the differential expression of CD83, human CD83-targeted CAR T cells prevent and treat GVHD, as well as kill myeloid leukemia...
Published July 27, 2020
Author's Take
JCI's Conversations with Giants in Medicine: Jesse Roth
We take it for granted today that each hormone and other intercellular messenger have their own specific receptors. But this was not the case until the groundbreaking work of Jesse Roth and his colleagues.
Published July 1, 2020
Conversations with Giants in Medicine
Microenvironmental Th9 and Th17 induce spreading in lung cancer
In this episode, Rajkumar Savai and colleagues explain that Th9 and Th17 lymphocytes induce lung cancer cell epithelial-mesenchymal transition via release of their signature cytokines, thereby promoting migration, vessel entry, and metastatic spreading...
Published June 2, 2020
Author's Take
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