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JCI’s Conversations with Giants in Medicine: Ending one conversation
In this final episode of the series, the Conversations with Giants in Medicine series comes to a close...
Published April 1, 2025
Conversations with Giants in Medicine

Baricitinib rapidly treats lichen planus by suppressing cytotoxic CXCL13+CD8+ T cells.
In this episode, Aaron R. Mangold explains how lichen planus is treated by suppressing cytotoxic CXCL13+CD8+ T-cells using baricitinib...
Published March 31, 2025
Video Abstracts

Electronic health record data and the estimation of autoimmune disease prevalence in the USA
In this video, DeLisa Fairweather, Aaron H. Abend, and Ingrid He explain that their paper estimates the prevalence of all autoimmune disease in the US...
Published February 17, 2025
Video Abstracts

JCI’s Conversations with Giants in Medicine: Zhijian (James) Chen
In this episode, Editor at Large Ushma Neill interviews Dr. Zhijian (James) Chen. Zhijian (James) Chen (University of Texas Southwestern and HHMI) has had a storied research career focused on the molecular mechanisms of innate immunity...
Published January 2, 2025
Conversations with Giants in Medicine

Chronic lymphocytic leukemia and the inducement of a nongenetic adaptation to ibrutinib
In this episode, Laura Ondrisova describes how this manuscript examines a non-genetic adaptation to BTK inhibitor therapy in chronic lymphocytic leukemia that involves Akt activation via FoxO1/Rictor axis...
Published December 2, 2024
Video Abstracts
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