Posts

518 items found.
The COVID-19 immune landscape correlation with disease severity
In this episode, Jane Buckner explains a longitudinal analysis of acute COVID-19 ranging from mild to severe disease determining immune trajectories of recovery...
Published February 1, 2021
Author's Take
Variant increases ER chaperones GRP78 and GRP94 and protects against liver injury
In this episode, Richard Austin, Paul Lebeau, and Michel Chrétien explain that the human Q152H ProPCSK9 mutation acquires an unexpected novel function: protection against ER stress and liver injury by enhancing chaperone expression...
Published January 19, 2021
Author's Take
Increased atrial fibrillation in diabetic mice by distinct mechanisms
In this episode, Olurotimi O. Mesubi explains that the discovery of oxidation of CaMKII and O-GlcNAcylation differentially increased atrial fibrillation risk in type 1 and type 2 diabetic mice...
Published January 19, 2021
Author's Take
JCI’s Conversations with Giants in Medicine: Griffin Rodgers
Beginning in the mid-1980s, Dr. Griffin Rodgers, Director of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health, led studies demonstrating the effectiveness of the drug hydroxyurea...
Published January 4, 2021
Conversations with Giants in Medicine
mTOR-dependent translation amplifies microglia priming
In this episode, Melania Capasso explains how mTOR is hyperactivated in microglia with age and causes increased translation of inflammatory mediators, thus critically regulating microglia priming...
Published January 4, 2021
Author's Take
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