Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews ...
    • Lung inflammatory injury and tissue repair (Jul 2023)
    • Immune Environment in Glioblastoma (Feb 2023)
    • Korsmeyer Award 25th Anniversary Collection (Jan 2023)
    • Aging (Jul 2022)
    • Next-Generation Sequencing in Medicine (Jun 2022)
    • New Therapeutic Targets in Cardiovascular Diseases (Mar 2022)
    • Immunometabolism (Jan 2022)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Commentaries
    • Research letters
    • Letters to the editor
    • Editorials
    • Viewpoint
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Author's Takes
  • In-Press Preview
  • Commentaries
  • Research letters
  • Letters to the editor
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Footnotes
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Expression of concern Free access | 10.1172/JCI97321

Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation

Cong Jin, Christopher P. Shelburne, Guojie Li, Erin N. Potts, Kristina J. Riebe, Gregory D. Sempowski, W. Michael Foster, and Soman N. Abraham

Find articles by Jin, C. in: JCI | PubMed | Google Scholar

Find articles by Shelburne, C. in: JCI | PubMed | Google Scholar

Find articles by Li, G. in: JCI | PubMed | Google Scholar

Find articles by Potts, E. in: JCI | PubMed | Google Scholar

Find articles by Riebe, K. in: JCI | PubMed | Google Scholar

Find articles by Sempowski, G. in: JCI | PubMed | Google Scholar

Find articles by Foster, W. in: JCI | PubMed | Google Scholar

Find articles by Abraham, S. in: JCI | PubMed | Google Scholar

Published September 18, 2017 - More info

Published in Volume 127, Issue 10 on October 2, 2017
J Clin Invest. 2017;127(10):3913–3913. https://doi.org/10.1172/JCI97321.
Copyright © 2017, American Society for Clinical Investigation
Published September 18, 2017 - Version history
View PDF

Related article:

Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation
Cong Jin, … , W. Michael Foster, Soman N. Abraham
Cong Jin, … , W. Michael Foster, Soman N. Abraham
Research Article Cell biology Immunology Inflammation Pulmonology

Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation

  • Text
  • PDF
Abstract

Allergic asthma is characterized by airway hyperresponsiveness, inflammation, and a cellular infiltrate dominated by eosinophils. Numerous epidemiological studies have related the exacerbation of allergic asthma with an increase in ambient inhalable particulate matter from air pollutants. This is because inhalable particles efficiently deliver airborne allergens deep into the airways, where they can aggravate allergic asthma symptoms. However, the cellular mechanisms by which inhalable particulate allergens (pAgs) potentiate asthmatic symptoms remain unknown, in part because most in vivo and in vitro studies exploring the pathogenesis of allergic asthma use soluble allergens (sAgs). Using a mouse model of allergic asthma, we found that, compared with their sAg counterparts, pAgs triggered markedly heightened pulmonary eosinophilia in allergen-sensitized mice. Mast cells (MCs) were implicated in this divergent response, as the differences in airway inflammatory responses provoked by the physical nature of the allergens were attenuated in MC-deficient mice. The pAgs were found to mediate MC-dependent responses by enhancing retention of pAg/IgE/FcεRI complexes within lipid raft–enriched, CD63+ endocytic compartments, which prolonged IgE/FcεRI-initiated signaling and resulted in heightened cytokine responses. These results reveal how the physical attributes of allergens can co-opt MC endocytic circuitry and signaling responses to aggravate pathological responses of allergic asthma in mice.

Authors

Cong Jin, Christopher P. Shelburne, Guojie Li, Kristina J. Riebe, Gregory D. Sempowski, W. Michael Foster, Soman N. Abraham

×

Original citation: J Clin Invest. 2011;121(3):941–955. https://doi.org/10.1172/JCI43584

Citation for this expression of concern: J Clin Invest. 2017;127(10):3913. https://doi.org/10.1172/JCI97321

An investigative committee at Duke University recently reported that a research technician in the animal pulmonary physiology laboratory fabricated and/or falsified flexiVent data reported in Figures 1A, 2A, and 7D of this paper. The Editorial Board is issuing this Expression of Concern to alert readers to these problems. The Editors have requested that the experiments in question be repeated by the authors and resubmitted to the Journal. We will inform our readers of the outcome after the data have been evaluated.

Footnotes

See the related article at Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation.

Version history
  • Version 1 (September 18, 2017): Electronic publication
  • Version 2 (October 2, 2017): Print issue publication

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Footnotes
  • Version history
Advertisement
Advertisement

Copyright © 2023 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts