Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Alerts
  • Advertising/recruitment
  • Subscribe
  • Contact
  • Current Issue
  • Past Issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews ...
    • 100th Anniversary of Insulin's Discovery (Jan 2021)
    • Hypoxia-inducible factors in disease pathophysiology and therapeutics (Oct 2020)
    • Latency in Infectious Disease (Jul 2020)
    • Immunotherapy in Hematological Cancers (Apr 2020)
    • Big Data's Future in Medicine (Feb 2020)
    • Mechanisms Underlying the Metabolic Syndrome (Oct 2019)
    • Reparative Immunology (Jul 2019)
    • View all review series ...
  • Viewpoint
  • Collections
    • Recently published
    • In-Press Preview
    • Commentaries
    • Concise Communication
    • Editorials
    • Viewpoint
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Author's Takes
  • Recently published
  • In-Press Preview
  • Commentaries
  • Concise Communication
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Alerts
  • Advertising/recruitment
  • Subscribe
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a letter
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need Help? E-mail the JCI
  • Top
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Erratum Free access | 10.1172/JCI72967

WAVE1 mediates suppression of phagocytosis by phospholipid-derived DAMPs

Ulrich Matt, Omar Sharif, Rui Martins, Tanja Furtner, Lorene Langeberg, Riem Gawish, Immanuel Elbau, Ana Zivkovic, Karin Lakovits, Olga Oskolkova, Bianca Doninger, Andreas Vychytil, Thomas Perkmann, Gernot Schabbauer, Christoph J. Binder, Valery N. Bochkov, John D. Scott, and Sylvia Knapp

Find articles by Matt, U. in: JCI | PubMed | Google Scholar

Find articles by Sharif, O. in: JCI | PubMed | Google Scholar

Find articles by Martins, R. in: JCI | PubMed | Google Scholar

Find articles by Furtner, T. in: JCI | PubMed | Google Scholar

Find articles by Langeberg, L. in: JCI | PubMed | Google Scholar

Find articles by Gawish, R. in: JCI | PubMed | Google Scholar

Find articles by Elbau, I. in: JCI | PubMed | Google Scholar

Find articles by Zivkovic, A. in: JCI | PubMed | Google Scholar

Find articles by Lakovits, K. in: JCI | PubMed | Google Scholar

Find articles by Oskolkova, O. in: JCI | PubMed | Google Scholar

Find articles by Doninger, B. in: JCI | PubMed | Google Scholar

Find articles by Vychytil, A. in: JCI | PubMed | Google Scholar

Find articles by Perkmann, T. in: JCI | PubMed | Google Scholar

Find articles by Schabbauer, G. in: JCI | PubMed | Google Scholar

Find articles by Binder, C. in: JCI | PubMed | Google Scholar

Find articles by Bochkov, V. in: JCI | PubMed | Google Scholar

Find articles by Scott, J. in: JCI | PubMed | Google Scholar

Find articles by Knapp, S. in: JCI | PubMed | Google Scholar

Published October 1, 2013 - More info

Published in Volume 123, Issue 10 on October 1, 2013
J Clin Invest. 2013;123(10):4540–4540. https://doi.org/10.1172/JCI72967.
© 2013 The American Society for Clinical Investigation
Published October 1, 2013 - Version history
View PDF

Related article:

WAVE1 mediates suppression of phagocytosis by phospholipid-derived DAMPs
Ulrich Matt, … , John D. Scott, Sylvia Knapp
Ulrich Matt, … , John D. Scott, Sylvia Knapp
Research Article Immunology

WAVE1 mediates suppression of phagocytosis by phospholipid-derived DAMPs

  • Text
  • PDF
Abstract

Clearance of invading pathogens is essential to preventing overwhelming inflammation and sepsis that are symptomatic of bacterial peritonitis. Macrophages participate in this innate immune response by engulfing and digesting pathogens, a process called phagocytosis. Oxidized phospholipids (OxPL) are danger-associated molecular patterns (DAMPs) generated in response to infection that can prevent the phagocytic clearance of bacteria. We investigated the mechanism underlying OxPL action in macrophages. Exposure to OxPL induced alterations in actin polymerization, resulting in spreading of peritoneal macrophages and diminished uptake of E. coli. Pharmacological and cell-based studies showed that an anchored pool of PKA mediates the effects of OxPL. Gene silencing approaches identified the A-kinase anchoring protein (AKAP) WAVE1 as an effector of OxPL action in vitro. Chimeric Wave1–/– mice survived significantly longer after infection with E. coli and OxPL treatment in vivo. Moreover, we found that endogenously generated OxPL in human peritoneal dialysis fluid from end-stage renal failure patients inhibited phagocytosis via WAVE1. Collectively, these data uncover an unanticipated role for WAVE1 as a critical modulator of the innate immune response to severe bacterial infections.

Authors

Ulrich Matt, Omar Sharif, Rui Martins, Tanja Furtner, Lorene Langeberg, Riem Gawish, Immanuel Elbau, Ana Zivkovic, Karin Lakovits, Olga Oskolkova, Bianca Doninger, Andreas Vychytil, Thomas Perkmann, Gernot Schabbauer, Christoph J. Binder, Valery N. Bochkov, John D. Scott, Sylvia Knapp

×

Original citation: J Clin Invest. 2013;123(7):3014–3024. doi:10.1172/JCI60681.

Citation for this erratum: J Clin Invest. 2013;123(10):4540. doi:10.1172/JCI72967.

A duplicate of Figure 6D was inadvertently printed as Figure 6F. The correct version of Figure 6F is below.

Figure 6

The JCI regrets the error.

Version history
  • Version 1 (October 1, 2013): No description

Article tools

  • View PDF
  • Download citation information
  • Send a letter
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need Help? E-mail the JCI

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Version history
Advertisement
Advertisement
Follow JCI:
Copyright © 2021 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts