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CorrigendumAutoimmunity Free access | 10.1172/JCI27030C1

TGF-γ signaling is required for the function of insulin-reactive T regulatory cells

Wei Du, F. Susan Wong, Ming O. Li, Jian Peng, Hao Qi, Richard A. Flavell, Robert Sherwin, and Li Wen

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Published June 1, 2006 - More info

Published in Volume 116, Issue 6 on June 1, 2006
J Clin Invest. 2006;116(6):1738–1738. https://doi.org/10.1172/JCI27030C1.
© 2006 The American Society for Clinical Investigation
Published June 1, 2006 - Version history
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Related article:

TGF-β signaling is required for the function of insulin-reactive T regulatory cells
Wei Du, … , Robert Sherwin, Li Wen
Wei Du, … , Robert Sherwin, Li Wen
Research Article Autoimmunity

TGF-β signaling is required for the function of insulin-reactive T regulatory cells

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Abstract

We have previously isolated insulin-reactive Tregs from diabetic NOD mice designated 2H6, from which TCR transgenic mice were generated. The T cells from these 2H6 transgenic mice recognize insulin but have suppressive properties in vitro. They protect NOD mice in vivo from spontaneous development of diabetes and adoptive transfer of disease caused by polyclonal diabetogenic spleen cells as well as the highly diabetogenic monoclonal BDC2.5 TCR transgenic T cells that recognize an islet granule antigen. Using cells from both NOD and BDC2.5 mice that express a dominant-negative TGF-β receptor type II (TGF-βDNRII), we show that 2H6 T cells protected from disease by producing TGF-β and that the ability of the target diabetogenic T cells to respond to TGF-β was crucial. We further demonstrate that TGF-β signaling in 2H6 cells was important for their protective properties, as 2H6 cells were unable to protect from adoptive transfer–induced diabetes if they were unable to respond to TGF-β. Thus, our data demonstrate that insulin-specific regulatory cells protect from diabetes by virtue of their production of TGF-β1 that acts in an autocrine manner to maintain their regulatory function and acts in a paracrine manner on the target cells.

Authors

Wei Du, F. Susan Wong, Ming O. Li, Jian Peng, Hao Qi, Richard A. Flavell, Robert Sherwin, Li Wen

×

Original citation: J. Clin. Invest.116:1360 -1370 (2006). doi:10.1172/JCI27030

Citation for this addendum: J. Clin. Invest.116:1738 (2006). doi:10.1172/JCI27030C1

The label for the x axis of Figure 2A was incorrect. The label should read "Insulin (µg/ml)." The correct version of Figure 2A follows.

The authors regret this error.

Version history
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