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Autophagy in cell death: an innocent convict?
Beth Levine and Junying Yuan
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Published December 1, 2006 - More info
J Clin Invest. 2006;116(12):3293–3293. https://doi.org/10.1172/JCI26390C1.
© 2006 The American Society for Clinical Investigation
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Abstract
The visualization of autophagosomes in dying cells has led to the belief that autophagy is a nonapoptotic form of programmed cell death. This concept has now been evaluated using cells and organisms deficient in autophagy genes. Most evidence indicates that, at least in cells with intact apoptotic machinery, autophagy is primarily a pro-survival rather than a pro-death mechanism. This review summarizes the evidence linking autophagy to cell survival and cell death, the complex interplay between autophagy and apoptosis pathways, and the role of autophagy-dependent survival and death pathways in clinical diseases.
Authors
Beth Levine, Junying Yuan
Original citation: J. Clin. Invest.115:2679-2688 (2005). doi:10.1172/JCI26390
Citation for this corrigendum: J. Clin. Invest.1163293 (2006). doi:10.1172/JCI26390C1
In Figure 2A, “Atg17” should not have been underlined. The corrected figure appears below.
The units "nmol" and "pmol" in the text and legends of the manuscript should read as "nmol/l" and "pmol/l," respectively.
The source for Figure 3A was cited incorrectly. The corrected statement and corrected reference appear below.
Images in A and B reproduced with permission from Nature Chemical Biology (98) and Landes Bioscience (90), respectively.
98. Degterev, A., et al. 2005. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat. Chem. Biol.1:112-119.
The authors regret this error.
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