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ResearchIn-Press PreviewCell biologyHematology
Open Access | 
10.1172/JCI203565
Disruption of methionine metabolism drives erythroid cell fate reprogramming by remodeling the H3K4me3 landscape
Lei Sun,1 Hengchao Zhang,1 Mengjia Li,1 Quande Lin,2 Xiuyun Wu,1 Ying Cheng,1 Shihui Wang,3 Yan Hou,1 Yaomei Wang,2 Yue Sheng,4 Jing Liu,5 Xiuli An,6 Ting Wang,1 and Lixiang Chen1
1Aging Decoding and Regeneration Institute, School of Life Sciences, Zhengzhou University, Zhengzhou, China
2Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
3Institute of Hematology, People's Hospital of Zhengzhou University, Zhengzhou, China
4Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China
5Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, China
6Laboratory of Membrane Biology, New York Blood Center, New York, United States of America
Find articles by Sun, L. in: PubMed | Google Scholar
1Aging Decoding and Regeneration Institute, School of Life Sciences, Zhengzhou University, Zhengzhou, China
2Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
3Institute of Hematology, People's Hospital of Zhengzhou University, Zhengzhou, China
4Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China
5Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, China
6Laboratory of Membrane Biology, New York Blood Center, New York, United States of America
Find articles by Zhang, H. in: PubMed | Google Scholar
1Aging Decoding and Regeneration Institute, School of Life Sciences, Zhengzhou University, Zhengzhou, China
2Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
3Institute of Hematology, People's Hospital of Zhengzhou University, Zhengzhou, China
4Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China
5Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, China
6Laboratory of Membrane Biology, New York Blood Center, New York, United States of America
Find articles by Li, M. in: PubMed | Google Scholar
1Aging Decoding and Regeneration Institute, School of Life Sciences, Zhengzhou University, Zhengzhou, China
2Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
3Institute of Hematology, People's Hospital of Zhengzhou University, Zhengzhou, China
4Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China
5Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, China
6Laboratory of Membrane Biology, New York Blood Center, New York, United States of America
Find articles by Lin, Q. in: PubMed | Google Scholar
1Aging Decoding and Regeneration Institute, School of Life Sciences, Zhengzhou University, Zhengzhou, China
2Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
3Institute of Hematology, People's Hospital of Zhengzhou University, Zhengzhou, China
4Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China
5Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, China
6Laboratory of Membrane Biology, New York Blood Center, New York, United States of America
Find articles by Wu, X. in: PubMed | Google Scholar
1Aging Decoding and Regeneration Institute, School of Life Sciences, Zhengzhou University, Zhengzhou, China
2Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
3Institute of Hematology, People's Hospital of Zhengzhou University, Zhengzhou, China
4Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China
5Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, China
6Laboratory of Membrane Biology, New York Blood Center, New York, United States of America
Find articles by Cheng, Y. in: PubMed | Google Scholar
1Aging Decoding and Regeneration Institute, School of Life Sciences, Zhengzhou University, Zhengzhou, China
2Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
3Institute of Hematology, People's Hospital of Zhengzhou University, Zhengzhou, China
4Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China
5Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, China
6Laboratory of Membrane Biology, New York Blood Center, New York, United States of America
Find articles by Wang, S. in: PubMed | Google Scholar
1Aging Decoding and Regeneration Institute, School of Life Sciences, Zhengzhou University, Zhengzhou, China
2Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
3Institute of Hematology, People's Hospital of Zhengzhou University, Zhengzhou, China
4Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China
5Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, China
6Laboratory of Membrane Biology, New York Blood Center, New York, United States of America
Find articles by Hou, Y. in: PubMed | Google Scholar
1Aging Decoding and Regeneration Institute, School of Life Sciences, Zhengzhou University, Zhengzhou, China
2Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
3Institute of Hematology, People's Hospital of Zhengzhou University, Zhengzhou, China
4Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China
5Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, China
6Laboratory of Membrane Biology, New York Blood Center, New York, United States of America
Find articles by Wang, Y. in: PubMed | Google Scholar
1Aging Decoding and Regeneration Institute, School of Life Sciences, Zhengzhou University, Zhengzhou, China
2Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
3Institute of Hematology, People's Hospital of Zhengzhou University, Zhengzhou, China
4Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China
5Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, China
6Laboratory of Membrane Biology, New York Blood Center, New York, United States of America
Find articles by Sheng, Y. in: PubMed | Google Scholar
1Aging Decoding and Regeneration Institute, School of Life Sciences, Zhengzhou University, Zhengzhou, China
2Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
3Institute of Hematology, People's Hospital of Zhengzhou University, Zhengzhou, China
4Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China
5Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, China
6Laboratory of Membrane Biology, New York Blood Center, New York, United States of America
Find articles by Liu, J. in: PubMed | Google Scholar
1Aging Decoding and Regeneration Institute, School of Life Sciences, Zhengzhou University, Zhengzhou, China
2Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
3Institute of Hematology, People's Hospital of Zhengzhou University, Zhengzhou, China
4Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China
5Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, China
6Laboratory of Membrane Biology, New York Blood Center, New York, United States of America
Find articles by An, X. in: PubMed | Google Scholar
1Aging Decoding and Regeneration Institute, School of Life Sciences, Zhengzhou University, Zhengzhou, China
2Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
3Institute of Hematology, People's Hospital of Zhengzhou University, Zhengzhou, China
4Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China
5Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, China
6Laboratory of Membrane Biology, New York Blood Center, New York, United States of America
Find articles by Wang, T. in: PubMed | Google Scholar
1Aging Decoding and Regeneration Institute, School of Life Sciences, Zhengzhou University, Zhengzhou, China
2Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
3Institute of Hematology, People's Hospital of Zhengzhou University, Zhengzhou, China
4Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China
5Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, China
6Laboratory of Membrane Biology, New York Blood Center, New York, United States of America
Find articles by Chen, L. in: PubMed | Google Scholar
Published July 14, 2026 - More info
Copyright © 2026, Sun et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)