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ResearchIn-Press PreviewCell biologyHepatology
Open Access | 
10.1172/JCI203412
ITGBL1-MYH9 interaction in hepatic stellate cells acts as a mechano-regulator controlling liver fibrosis in mice
Yixin Li,1 Yan Wang,2 Chenhao Tong,3 Xinghuan Fu,2 Ningning Ma,4 Yawen Hao,4 Zian Feng,1 Shijia Ling,5 Zequn Yin,1 Haodong Li,6 Shujun Ge,5 Siting Yang,5 Peng Xiao,7 Siyue Dong,5 Adrien Guillot,8 Yajun Duan,1 and Yong He4
1The First Affiliated Hospital of USTC, Division of Life Sciences and Medici, University of Science and Technology of China (USTC), Hefei, China
2Department of Infectious Diseases, Peking University First Hospital, Beijing, China
3Hepatopancreatobiliary Surgery Department, The First Affiliated Hospital of Ningbo University, Ningbo, China
4State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China
5School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China
6Tianjing University of Traditional Chinese Medicine, Tianjing, China
7Department of Hepatology, The First Hospital of Jilin University, Changchun, China
8Department of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany
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1The First Affiliated Hospital of USTC, Division of Life Sciences and Medici, University of Science and Technology of China (USTC), Hefei, China
2Department of Infectious Diseases, Peking University First Hospital, Beijing, China
3Hepatopancreatobiliary Surgery Department, The First Affiliated Hospital of Ningbo University, Ningbo, China
4State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China
5School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China
6Tianjing University of Traditional Chinese Medicine, Tianjing, China
7Department of Hepatology, The First Hospital of Jilin University, Changchun, China
8Department of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany
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1The First Affiliated Hospital of USTC, Division of Life Sciences and Medici, University of Science and Technology of China (USTC), Hefei, China
2Department of Infectious Diseases, Peking University First Hospital, Beijing, China
3Hepatopancreatobiliary Surgery Department, The First Affiliated Hospital of Ningbo University, Ningbo, China
4State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China
5School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China
6Tianjing University of Traditional Chinese Medicine, Tianjing, China
7Department of Hepatology, The First Hospital of Jilin University, Changchun, China
8Department of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany
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1The First Affiliated Hospital of USTC, Division of Life Sciences and Medici, University of Science and Technology of China (USTC), Hefei, China
2Department of Infectious Diseases, Peking University First Hospital, Beijing, China
3Hepatopancreatobiliary Surgery Department, The First Affiliated Hospital of Ningbo University, Ningbo, China
4State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China
5School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China
6Tianjing University of Traditional Chinese Medicine, Tianjing, China
7Department of Hepatology, The First Hospital of Jilin University, Changchun, China
8Department of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany
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1The First Affiliated Hospital of USTC, Division of Life Sciences and Medici, University of Science and Technology of China (USTC), Hefei, China
2Department of Infectious Diseases, Peking University First Hospital, Beijing, China
3Hepatopancreatobiliary Surgery Department, The First Affiliated Hospital of Ningbo University, Ningbo, China
4State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China
5School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China
6Tianjing University of Traditional Chinese Medicine, Tianjing, China
7Department of Hepatology, The First Hospital of Jilin University, Changchun, China
8Department of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany
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1The First Affiliated Hospital of USTC, Division of Life Sciences and Medici, University of Science and Technology of China (USTC), Hefei, China
2Department of Infectious Diseases, Peking University First Hospital, Beijing, China
3Hepatopancreatobiliary Surgery Department, The First Affiliated Hospital of Ningbo University, Ningbo, China
4State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China
5School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China
6Tianjing University of Traditional Chinese Medicine, Tianjing, China
7Department of Hepatology, The First Hospital of Jilin University, Changchun, China
8Department of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany
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1The First Affiliated Hospital of USTC, Division of Life Sciences and Medici, University of Science and Technology of China (USTC), Hefei, China
2Department of Infectious Diseases, Peking University First Hospital, Beijing, China
3Hepatopancreatobiliary Surgery Department, The First Affiliated Hospital of Ningbo University, Ningbo, China
4State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China
5School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China
6Tianjing University of Traditional Chinese Medicine, Tianjing, China
7Department of Hepatology, The First Hospital of Jilin University, Changchun, China
8Department of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany
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1The First Affiliated Hospital of USTC, Division of Life Sciences and Medici, University of Science and Technology of China (USTC), Hefei, China
2Department of Infectious Diseases, Peking University First Hospital, Beijing, China
3Hepatopancreatobiliary Surgery Department, The First Affiliated Hospital of Ningbo University, Ningbo, China
4State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China
5School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China
6Tianjing University of Traditional Chinese Medicine, Tianjing, China
7Department of Hepatology, The First Hospital of Jilin University, Changchun, China
8Department of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany
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1The First Affiliated Hospital of USTC, Division of Life Sciences and Medici, University of Science and Technology of China (USTC), Hefei, China
2Department of Infectious Diseases, Peking University First Hospital, Beijing, China
3Hepatopancreatobiliary Surgery Department, The First Affiliated Hospital of Ningbo University, Ningbo, China
4State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China
5School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China
6Tianjing University of Traditional Chinese Medicine, Tianjing, China
7Department of Hepatology, The First Hospital of Jilin University, Changchun, China
8Department of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany
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1The First Affiliated Hospital of USTC, Division of Life Sciences and Medici, University of Science and Technology of China (USTC), Hefei, China
2Department of Infectious Diseases, Peking University First Hospital, Beijing, China
3Hepatopancreatobiliary Surgery Department, The First Affiliated Hospital of Ningbo University, Ningbo, China
4State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China
5School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China
6Tianjing University of Traditional Chinese Medicine, Tianjing, China
7Department of Hepatology, The First Hospital of Jilin University, Changchun, China
8Department of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany
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1The First Affiliated Hospital of USTC, Division of Life Sciences and Medici, University of Science and Technology of China (USTC), Hefei, China
2Department of Infectious Diseases, Peking University First Hospital, Beijing, China
3Hepatopancreatobiliary Surgery Department, The First Affiliated Hospital of Ningbo University, Ningbo, China
4State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China
5School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China
6Tianjing University of Traditional Chinese Medicine, Tianjing, China
7Department of Hepatology, The First Hospital of Jilin University, Changchun, China
8Department of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany
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1The First Affiliated Hospital of USTC, Division of Life Sciences and Medici, University of Science and Technology of China (USTC), Hefei, China
2Department of Infectious Diseases, Peking University First Hospital, Beijing, China
3Hepatopancreatobiliary Surgery Department, The First Affiliated Hospital of Ningbo University, Ningbo, China
4State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China
5School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China
6Tianjing University of Traditional Chinese Medicine, Tianjing, China
7Department of Hepatology, The First Hospital of Jilin University, Changchun, China
8Department of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany
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1The First Affiliated Hospital of USTC, Division of Life Sciences and Medici, University of Science and Technology of China (USTC), Hefei, China
2Department of Infectious Diseases, Peking University First Hospital, Beijing, China
3Hepatopancreatobiliary Surgery Department, The First Affiliated Hospital of Ningbo University, Ningbo, China
4State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China
5School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China
6Tianjing University of Traditional Chinese Medicine, Tianjing, China
7Department of Hepatology, The First Hospital of Jilin University, Changchun, China
8Department of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany
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1The First Affiliated Hospital of USTC, Division of Life Sciences and Medici, University of Science and Technology of China (USTC), Hefei, China
2Department of Infectious Diseases, Peking University First Hospital, Beijing, China
3Hepatopancreatobiliary Surgery Department, The First Affiliated Hospital of Ningbo University, Ningbo, China
4State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China
5School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China
6Tianjing University of Traditional Chinese Medicine, Tianjing, China
7Department of Hepatology, The First Hospital of Jilin University, Changchun, China
8Department of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany
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1The First Affiliated Hospital of USTC, Division of Life Sciences and Medici, University of Science and Technology of China (USTC), Hefei, China
2Department of Infectious Diseases, Peking University First Hospital, Beijing, China
3Hepatopancreatobiliary Surgery Department, The First Affiliated Hospital of Ningbo University, Ningbo, China
4State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China
5School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China
6Tianjing University of Traditional Chinese Medicine, Tianjing, China
7Department of Hepatology, The First Hospital of Jilin University, Changchun, China
8Department of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany
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1The First Affiliated Hospital of USTC, Division of Life Sciences and Medici, University of Science and Technology of China (USTC), Hefei, China
2Department of Infectious Diseases, Peking University First Hospital, Beijing, China
3Hepatopancreatobiliary Surgery Department, The First Affiliated Hospital of Ningbo University, Ningbo, China
4State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China
5School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China
6Tianjing University of Traditional Chinese Medicine, Tianjing, China
7Department of Hepatology, The First Hospital of Jilin University, Changchun, China
8Department of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany
Find articles by Duan, Y. in: PubMed | Google Scholar
1The First Affiliated Hospital of USTC, Division of Life Sciences and Medici, University of Science and Technology of China (USTC), Hefei, China
2Department of Infectious Diseases, Peking University First Hospital, Beijing, China
3Hepatopancreatobiliary Surgery Department, The First Affiliated Hospital of Ningbo University, Ningbo, China
4State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China
5School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China
6Tianjing University of Traditional Chinese Medicine, Tianjing, China
7Department of Hepatology, The First Hospital of Jilin University, Changchun, China
8Department of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany
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Published July 16, 2026 - More info
Copyright © 2026, Li et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)