Advertisement
ResearchIn-Press PreviewCell biologyHematology
Open Access | 
10.1172/JCI201621
Immune subtypes of megakaryocytes orchestrate inflammatory and regulatory responses to pulmonary infection via Treg crosstalk
Huizhen He,1 Yezi Ma,1 Yifei Cai,1 xiaoyuan chen,1 Tianran Cheng,1 Ziqi Huo,1 Sibei Guo,2 Meijuan Xia,1 Dan Feng,1 Minmin Li,1 Jingjing Zhao,1 Nananan Zhao,1 Pei Su,1 Wen Zhou,3 Fei Wang,4 Cuicui Liu,1 Hongtao Wang,1 and Jiaxi Zhou1
1State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
2Haihe Laboratory of Cell Ecosystem, Tianjin Medical University, Tianjin, China
3Cancer Research Institute, Central South University, Changsha, China
4HaemoCure Inc, Tianjin, China
Find articles by He, H. in: PubMed | Google Scholar
1State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
2Haihe Laboratory of Cell Ecosystem, Tianjin Medical University, Tianjin, China
3Cancer Research Institute, Central South University, Changsha, China
4HaemoCure Inc, Tianjin, China
Find articles by Ma, Y. in: PubMed | Google Scholar
1State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
2Haihe Laboratory of Cell Ecosystem, Tianjin Medical University, Tianjin, China
3Cancer Research Institute, Central South University, Changsha, China
4HaemoCure Inc, Tianjin, China
Find articles by Cai, Y. in: PubMed | Google Scholar
1State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
2Haihe Laboratory of Cell Ecosystem, Tianjin Medical University, Tianjin, China
3Cancer Research Institute, Central South University, Changsha, China
4HaemoCure Inc, Tianjin, China
Find articles by chen, x. in: PubMed | Google Scholar
1State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
2Haihe Laboratory of Cell Ecosystem, Tianjin Medical University, Tianjin, China
3Cancer Research Institute, Central South University, Changsha, China
4HaemoCure Inc, Tianjin, China
Find articles by Cheng, T. in: PubMed | Google Scholar
1State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
2Haihe Laboratory of Cell Ecosystem, Tianjin Medical University, Tianjin, China
3Cancer Research Institute, Central South University, Changsha, China
4HaemoCure Inc, Tianjin, China
Find articles by Huo, Z. in: PubMed | Google Scholar
1State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
2Haihe Laboratory of Cell Ecosystem, Tianjin Medical University, Tianjin, China
3Cancer Research Institute, Central South University, Changsha, China
4HaemoCure Inc, Tianjin, China
Find articles by Guo, S. in: PubMed | Google Scholar
1State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
2Haihe Laboratory of Cell Ecosystem, Tianjin Medical University, Tianjin, China
3Cancer Research Institute, Central South University, Changsha, China
4HaemoCure Inc, Tianjin, China
Find articles by Xia, M. in: PubMed | Google Scholar
1State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
2Haihe Laboratory of Cell Ecosystem, Tianjin Medical University, Tianjin, China
3Cancer Research Institute, Central South University, Changsha, China
4HaemoCure Inc, Tianjin, China
Find articles by Feng, D. in: PubMed | Google Scholar
1State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
2Haihe Laboratory of Cell Ecosystem, Tianjin Medical University, Tianjin, China
3Cancer Research Institute, Central South University, Changsha, China
4HaemoCure Inc, Tianjin, China
Find articles by Li, M. in: PubMed | Google Scholar
1State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
2Haihe Laboratory of Cell Ecosystem, Tianjin Medical University, Tianjin, China
3Cancer Research Institute, Central South University, Changsha, China
4HaemoCure Inc, Tianjin, China
Find articles by Zhao, J. in: PubMed | Google Scholar
1State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
2Haihe Laboratory of Cell Ecosystem, Tianjin Medical University, Tianjin, China
3Cancer Research Institute, Central South University, Changsha, China
4HaemoCure Inc, Tianjin, China
Find articles by Zhao, N. in: PubMed | Google Scholar
1State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
2Haihe Laboratory of Cell Ecosystem, Tianjin Medical University, Tianjin, China
3Cancer Research Institute, Central South University, Changsha, China
4HaemoCure Inc, Tianjin, China
Find articles by Su, P. in: PubMed | Google Scholar
1State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
2Haihe Laboratory of Cell Ecosystem, Tianjin Medical University, Tianjin, China
3Cancer Research Institute, Central South University, Changsha, China
4HaemoCure Inc, Tianjin, China
Find articles by Zhou, W. in: PubMed | Google Scholar
1State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
2Haihe Laboratory of Cell Ecosystem, Tianjin Medical University, Tianjin, China
3Cancer Research Institute, Central South University, Changsha, China
4HaemoCure Inc, Tianjin, China
Find articles by Wang, F. in: PubMed | Google Scholar
1State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
2Haihe Laboratory of Cell Ecosystem, Tianjin Medical University, Tianjin, China
3Cancer Research Institute, Central South University, Changsha, China
4HaemoCure Inc, Tianjin, China
Find articles by Liu, C. in: PubMed | Google Scholar
1State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
2Haihe Laboratory of Cell Ecosystem, Tianjin Medical University, Tianjin, China
3Cancer Research Institute, Central South University, Changsha, China
4HaemoCure Inc, Tianjin, China
Find articles by Wang, H. in: PubMed | Google Scholar
1State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
2Haihe Laboratory of Cell Ecosystem, Tianjin Medical University, Tianjin, China
3Cancer Research Institute, Central South University, Changsha, China
4HaemoCure Inc, Tianjin, China
Find articles by Zhou, J. in: PubMed | Google Scholar
Published September 29, 2026 - More info
Copyright © 2026, He et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)