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ResearchIn-Press PreviewGastroenterologyHepatology
Open Access | 
10.1172/JCI200522
Metabolic dysfunction-associated steatohepatitis exacerbated by Clostridium perfringens-derived ammonia is attenuated by tripeptide DT-109
Pengxiang Qu,1 Shusi Ding,2 Yanru Zhang,1 Yang Zhao,3 Erfei Song,4 Liangshuo Hu,5 Ruike Ding,1 Wenbin Cao,1 Yiting Hou,1 Jia Qi,1 Juan Zhao,1 Chenjing Duan,1 Shuangqing Liu,1 Chong Shen,1 Ying Zhao,3 Yanhong Guo,3 Zuowen Zheng,6 Shiwei Luo,1 Huizhong Hu,1 Liang Bai,1 Sihai Zhao,1 Bo Wang,5 Shuixiang He,1 Yi Wu,1 Xuelian Xiong,7 Qiutong Wu,8 Weiwang Gu,9 Oren Rom,10 Aimin Xu,11 Lemin Zheng,2 Jifeng Zhang,3 Enqi Liu,1 and Y. Eugene Chen3
1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
Find articles by Qu, P. in: PubMed | Google Scholar
1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
Find articles by Ding, S. in: PubMed | Google Scholar
1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
Find articles by Zhang, Y. in: PubMed | Google Scholar
1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
Find articles by
Zhao, Y.
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1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
Find articles by Song, E. in: PubMed | Google Scholar
1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
Find articles by Hu, L. in: PubMed | Google Scholar
1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
Find articles by Ding, R. in: PubMed | Google Scholar
1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
Find articles by Cao, W. in: PubMed | Google Scholar
1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
Find articles by Hou, Y. in: PubMed | Google Scholar
1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
Find articles by Qi, J. in: PubMed | Google Scholar
1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
Find articles by Zhao, J. in: PubMed | Google Scholar
1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
Find articles by Duan, C. in: PubMed | Google Scholar
1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
Find articles by Liu, S. in: PubMed | Google Scholar
1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
Find articles by Shen, C. in: PubMed | Google Scholar
1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
Find articles by Zhao, Y. in: PubMed | Google Scholar
1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
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Guo, Y.
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1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
Find articles by Zheng, Z. in: PubMed | Google Scholar
1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
Find articles by Luo, S. in: PubMed | Google Scholar
1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
Find articles by Hu, H. in: PubMed | Google Scholar
1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
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1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
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1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
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1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
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1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
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1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
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1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
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1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
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1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
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1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
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1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
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1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
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1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
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1Laboratory Animal Center, Department of Gastroenterology, School of Basic Science, Xi'an Jiaotong University, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of Ch, Xi'an, China
2Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America
4Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China
5Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Spring Biological Technology Development Co., Ltd, Traditional Chinese Medical University, Nanning, China
7Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
8The Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, China
9Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China
10Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America
11State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicin, Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong, China
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Published May 12, 2026 - More info
Copyright © 2026, Qu et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)