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ResearchIn-Press PreviewCell biologyEndocrinologyGenetics Open Access | 10.1172/JCI195756

Recessive TMEM167A variants cause neonatal diabetes, microcephaly and epilepsy syndrome

Enrico Virgilio,1 Sylvia Tielens,2 Georgia Bonfield,3 Fang-Shin Nian,2 Toshiaki Sawatani,1 Chiara Vinci,1 Molly Govier,3 Hossam Montaser,5 Romane Lartigue,6 Anoop Arunagiri,7 Alexandrine Liboz,1 Flavia Natividade da Silva,1 Maria Lytrivi,1 Theodora Papadopoulou,1 Matthew N. Wakeling,3 James Russ-Silsby,3 Pamela Bowman,3 Matthew B. Johnson,3 Thomas W. Laver,3 Anthony Piron,1 Xiaoyan Yi,1 Federica Fantuzzi,1 Sirine Hendrickx,1 Mariana Igoillo-Esteve,1 Bruno J. Santacreu,1 Jananie Suntharesan,8 Radha Ghildiyal,9 Darshan G. Hegde,9 Nikhil Avnish Shah,9 Sezer Acar,10 Beyhan Özkaya Dönmez,10 Behzat Özkan,10 Fauzia Mohsin,11 Iman M. Talaat,12 Mohamed Tarek Abbas,12 Omar Saied Abbas,12 Hamed Ali Alghamdi,13 Nurgun Kandemir,14 Sarah E. Flanagan,3 Raphael Scharfmann,15 Peter Arvan,7 Matthieu Raoux,6 Laurent Nguyen,2 Andrew T. Hattersley,3 Miriam Cnop,1 and Elisa De Franco3

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Virgilio, E. in: PubMed | Google Scholar

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Tielens, S. in: PubMed | Google Scholar

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Bonfield, G. in: PubMed | Google Scholar

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Nian, F. in: PubMed | Google Scholar

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Sawatani, T. in: PubMed | Google Scholar

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Vinci, C. in: PubMed | Google Scholar

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Govier, M. in: PubMed | Google Scholar

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Montaser, H. in: PubMed | Google Scholar

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Lartigue, R. in: PubMed | Google Scholar

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Arunagiri, A. in: PubMed | Google Scholar |

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Liboz, A. in: PubMed | Google Scholar

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Natividade da Silva, F. in: PubMed | Google Scholar

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Lytrivi, M. in: PubMed | Google Scholar |

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Papadopoulou, T. in: PubMed | Google Scholar

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Wakeling, M. in: PubMed | Google Scholar

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Russ-Silsby, J. in: PubMed | Google Scholar

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Bowman, P. in: PubMed | Google Scholar

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Johnson, M. in: PubMed | Google Scholar |

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Laver, T. in: PubMed | Google Scholar |

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

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1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

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1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

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1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

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1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

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1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

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1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

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1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

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1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

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1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Shah, N. in: PubMed | Google Scholar

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

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1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

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1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

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1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

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1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

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1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Abbas, M. in: PubMed | Google Scholar

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Abbas, O. in: PubMed | Google Scholar

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

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1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Kandemir, N. in: PubMed | Google Scholar

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Flanagan, S. in: PubMed | Google Scholar |

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

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1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

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1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

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1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

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1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

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1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

Find articles by Cnop, M. in: PubMed | Google Scholar

1ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

2Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, Belgium

3Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Belgium

5Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

6CNRS, Bordeaux INP, CBMN, University of Bordeaux, Bordeaux, France

7Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America

8Sirimavo Bandaranayake Specialized Children’s Hospital, Peradeniya, Sri Lanka

9Department of Pediatrics, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai, India

10Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

11Department of Pediatrics, BIRDEM General Hospital, Dhaka, Bangladesh

12Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

13Northern Area Armed Forces Hospital, King Khalid Military City, Saudi Arabia

14Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

15Institut Cochin, INSERM-U1016, Université Paris Cité, Paris, France

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Published September 9, 2025 - More info

J Clin Invest. https://doi.org/10.1172/JCI195756.
Copyright © 2025, Virgilio et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Published September 9, 2025 - Version history
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Abstract

Understanding the genetic causes of diseases affecting pancreatic β cells and neurons can give insights into pathways essential for both cell types. Microcephaly, epilepsy and diabetes syndrome (MEDS) is a congenital disorder with two known aetiological genes, IER3IP1 and YIPF5. Both genes encode proteins involved in endoplasmic reticulum (ER) to Golgi trafficking. We used genome sequencing to identify 6 individuals with MEDS caused by biallelic variants in the novel disease gene, TMEM167A. All had neonatal diabetes (diagnosed <6 months) and severe microcephaly, five also had epilepsy. TMEM167A is highly expressed in developing and adult human pancreas and brain. To gain insights into the mechanisms leading to diabetes, we silenced TMEM167A in EndoC-βH1 cells and knocked-in one patient’s variant, p.Val59Glu, in induced pluripotent stem cells (iPSCs). Both TMEM167A depletion in EndoC-βH1 cells and the p.Val59Glu variant in iPSC-derived β cells sensitized β cells to ER stress. The p.Val59Glu variant impaired proinsulin trafficking to the Golgi and induced iPSC-β cell dysfunction. The discovery of TMEM167A variants as a new genetic cause of MEDS highlights a critical role of TMEM167A in the ER to Golgi pathway in β cells and neurons.

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