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ResearchIn-Press PreviewAutoimmunityInfectious disease
Open Access | 
10.1172/JCI192619
Combined FXIII-C3 autoantibodies elicit bleeding and complement dysfunction in autoimmune FXIII deficiency
Shanshan Luo,1 Jun Deng,1 Yue Liu,2 Lv Xiong,1 Wanting Wang,1 Chaofan Wang,1 Yaohua Cai,1 Yajie Ding,1 Bahgat Fayed,3 Zhipeng Cheng,1 Lu Zhang,1 Min Zhang,1 Jun Fang,1 Gensheng Zhang,4 Rui Zhu,5 Haiqiang Jiang,6 Yunlun Li,6 Kun Huang,7 Xiang Cheng,8 Liang V. Tang,1 Chunyan Sun,1 Heng Mei,1 Peter F. Zipfel,9 Huafang Wang,1 Yadan Wang,1 Desheng Hu,10 and Yu Hu1
1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Find articles by Luo, S. in: PubMed | Google Scholar
1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Find articles by Deng, J. in: PubMed | Google Scholar
1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Find articles by Liu, Y. in: PubMed | Google Scholar
1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Find articles by Xiong, L. in: PubMed | Google Scholar
1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Find articles by Wang, W. in: PubMed | Google Scholar
1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Find articles by Wang, C. in: PubMed | Google Scholar
1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt
4Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
5Department of Integrated Traditional Chinese and Western Medicine, Union Ho, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
7School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
9Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
10Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Find articles by Hu, Y. in: PubMed | Google Scholar
Published December 9, 2025 - More info
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