Mutated FGFR1 is an oncogenic driver and therapeutic target in high-risk neuroblastoma

¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

Find articles by Kahlert, Y. in: PubMed | Google Scholar

¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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¹Department of Experimental Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, United States of America

³Department of Translational Genomics, University of Cologne, Cologne, Germany

⁴Department of Pediatric Oncology and Hematology, University of Cologne, Cologne, Germany

⁵Department of Neurology, University of Cologne, Cologne, Germany

⁶Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany

⁷Department of Pathology, Oslo University Hospital, Oslo, Norway

⁸Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway

⁹The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

¹⁰St Anna Children's Cancer Research Institute, Vienna, Austria

¹¹Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

¹²University Children's Hospital, Eberhard Karls University, Tuebingen, Germany

¹³Great Ormond Street Hospital, London, United Kingdom

¹⁴Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy

¹⁵Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, United States of America

¹⁶Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

¹⁷Oncogenetic Lab, Institute Curie, Paris, France

¹⁸RTOP (Recherche Translationelle en Oncologie Pédiatrique); INSERM U830, and, PSL Research University, Institute Curie, Paris, Belgium

¹⁹Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

²⁰Institute of Pathology, University of Cologne, Cologne, Germany

²¹Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

²²Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany

²³Koeln Fortune Program, University Hospital Cologne, Cologne, Germany

²⁴Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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