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ResearchIn-Press PreviewInfectious diseaseInflammation
Open Access | 
10.1172/JCI184721
IGFBP6 orchestrates anti-infective immune collapse in murine sepsis via prohibitin-2-mediated immunosuppression
Kai Chen,1 Ying Hu,1 Xiaoyan Yu,1 Hong Tang,2 Yanting Ruan,1 Yue Li,3 Xun Gao,4 Qing Zhao,5 Hong Wang,6 Xuemei Zhang,6 David Paul Molloy,7 Yibing Yin,6 Dapeng Chen,8 and Zhixin Song1
1Department of Clinical Laboratory, Children’s Hospital of Chongqing Medical University, Chongqing, China
2Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
3Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China
4Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, China
5Department of Laboratory Medicine, The Second Affliated Hospital of Chongqing Medical University, Chongqing, China
6Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine, Chongqing Medical University, Chongqing, China
7Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing, China
8Department of Clinical Laboratory, Children's Hospital of Chongqing Medical University, Chongqing, China
Find articles by Chen, K. in: PubMed | Google Scholar
1Department of Clinical Laboratory, Children’s Hospital of Chongqing Medical University, Chongqing, China
2Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
3Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China
4Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, China
5Department of Laboratory Medicine, The Second Affliated Hospital of Chongqing Medical University, Chongqing, China
6Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine, Chongqing Medical University, Chongqing, China
7Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing, China
8Department of Clinical Laboratory, Children's Hospital of Chongqing Medical University, Chongqing, China
Find articles by Hu, Y. in: PubMed | Google Scholar
1Department of Clinical Laboratory, Children’s Hospital of Chongqing Medical University, Chongqing, China
2Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
3Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China
4Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, China
5Department of Laboratory Medicine, The Second Affliated Hospital of Chongqing Medical University, Chongqing, China
6Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine, Chongqing Medical University, Chongqing, China
7Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing, China
8Department of Clinical Laboratory, Children's Hospital of Chongqing Medical University, Chongqing, China
Find articles by Yu, X. in: PubMed | Google Scholar
1Department of Clinical Laboratory, Children’s Hospital of Chongqing Medical University, Chongqing, China
2Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
3Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China
4Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, China
5Department of Laboratory Medicine, The Second Affliated Hospital of Chongqing Medical University, Chongqing, China
6Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine, Chongqing Medical University, Chongqing, China
7Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing, China
8Department of Clinical Laboratory, Children's Hospital of Chongqing Medical University, Chongqing, China
Find articles by Tang, H. in: PubMed | Google Scholar
1Department of Clinical Laboratory, Children’s Hospital of Chongqing Medical University, Chongqing, China
2Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
3Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China
4Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, China
5Department of Laboratory Medicine, The Second Affliated Hospital of Chongqing Medical University, Chongqing, China
6Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine, Chongqing Medical University, Chongqing, China
7Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing, China
8Department of Clinical Laboratory, Children's Hospital of Chongqing Medical University, Chongqing, China
Find articles by Ruan, Y. in: PubMed | Google Scholar
1Department of Clinical Laboratory, Children’s Hospital of Chongqing Medical University, Chongqing, China
2Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
3Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China
4Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, China
5Department of Laboratory Medicine, The Second Affliated Hospital of Chongqing Medical University, Chongqing, China
6Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine, Chongqing Medical University, Chongqing, China
7Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing, China
8Department of Clinical Laboratory, Children's Hospital of Chongqing Medical University, Chongqing, China
Find articles by Li, Y. in: PubMed | Google Scholar
1Department of Clinical Laboratory, Children’s Hospital of Chongqing Medical University, Chongqing, China
2Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
3Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China
4Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, China
5Department of Laboratory Medicine, The Second Affliated Hospital of Chongqing Medical University, Chongqing, China
6Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine, Chongqing Medical University, Chongqing, China
7Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing, China
8Department of Clinical Laboratory, Children's Hospital of Chongqing Medical University, Chongqing, China
Find articles by Gao, X. in: PubMed | Google Scholar
1Department of Clinical Laboratory, Children’s Hospital of Chongqing Medical University, Chongqing, China
2Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
3Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China
4Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, China
5Department of Laboratory Medicine, The Second Affliated Hospital of Chongqing Medical University, Chongqing, China
6Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine, Chongqing Medical University, Chongqing, China
7Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing, China
8Department of Clinical Laboratory, Children's Hospital of Chongqing Medical University, Chongqing, China
Find articles by Zhao, Q. in: PubMed | Google Scholar
1Department of Clinical Laboratory, Children’s Hospital of Chongqing Medical University, Chongqing, China
2Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
3Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China
4Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, China
5Department of Laboratory Medicine, The Second Affliated Hospital of Chongqing Medical University, Chongqing, China
6Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine, Chongqing Medical University, Chongqing, China
7Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing, China
8Department of Clinical Laboratory, Children's Hospital of Chongqing Medical University, Chongqing, China
Find articles by Wang, H. in: PubMed | Google Scholar
1Department of Clinical Laboratory, Children’s Hospital of Chongqing Medical University, Chongqing, China
2Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
3Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China
4Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, China
5Department of Laboratory Medicine, The Second Affliated Hospital of Chongqing Medical University, Chongqing, China
6Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine, Chongqing Medical University, Chongqing, China
7Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing, China
8Department of Clinical Laboratory, Children's Hospital of Chongqing Medical University, Chongqing, China
Find articles by Zhang, X. in: PubMed | Google Scholar
1Department of Clinical Laboratory, Children’s Hospital of Chongqing Medical University, Chongqing, China
2Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
3Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China
4Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, China
5Department of Laboratory Medicine, The Second Affliated Hospital of Chongqing Medical University, Chongqing, China
6Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine, Chongqing Medical University, Chongqing, China
7Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing, China
8Department of Clinical Laboratory, Children's Hospital of Chongqing Medical University, Chongqing, China
Find articles by Molloy, D. in: PubMed | Google Scholar
1Department of Clinical Laboratory, Children’s Hospital of Chongqing Medical University, Chongqing, China
2Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
3Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China
4Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, China
5Department of Laboratory Medicine, The Second Affliated Hospital of Chongqing Medical University, Chongqing, China
6Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine, Chongqing Medical University, Chongqing, China
7Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing, China
8Department of Clinical Laboratory, Children's Hospital of Chongqing Medical University, Chongqing, China
Find articles by Yin, Y. in: PubMed | Google Scholar
1Department of Clinical Laboratory, Children’s Hospital of Chongqing Medical University, Chongqing, China
2Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
3Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China
4Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, China
5Department of Laboratory Medicine, The Second Affliated Hospital of Chongqing Medical University, Chongqing, China
6Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine, Chongqing Medical University, Chongqing, China
7Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing, China
8Department of Clinical Laboratory, Children's Hospital of Chongqing Medical University, Chongqing, China
Find articles by Chen, D. in: PubMed | Google Scholar
1Department of Clinical Laboratory, Children’s Hospital of Chongqing Medical University, Chongqing, China
2Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
3Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China
4Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, China
5Department of Laboratory Medicine, The Second Affliated Hospital of Chongqing Medical University, Chongqing, China
6Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine, Chongqing Medical University, Chongqing, China
7Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing, China
8Department of Clinical Laboratory, Children's Hospital of Chongqing Medical University, Chongqing, China
Find articles by Song, Z. in: PubMed | Google Scholar
Published September 2, 2025 - More info
Copyright © 2025, Chen et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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ISSN: 0021-9738 (print), 1558-8238 (online)