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ResearchIn-Press PreviewNeuroscience Open Access | 10.1172/JCI165523
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States of America
4Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan
5Jean-Pierre Aubert Research Centre, University of Lille, Lille, France
6Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, United States of America
7Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, United States of America
Find articles by Siew, J. in: JCI | PubMed | Google Scholar |
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States of America
4Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan
5Jean-Pierre Aubert Research Centre, University of Lille, Lille, France
6Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, United States of America
7Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, United States of America
Find articles by Chen, H. in: JCI | PubMed | Google Scholar |
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States of America
4Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan
5Jean-Pierre Aubert Research Centre, University of Lille, Lille, France
6Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, United States of America
7Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, United States of America
Find articles by Chiu, F. in: JCI | PubMed | Google Scholar
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States of America
4Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan
5Jean-Pierre Aubert Research Centre, University of Lille, Lille, France
6Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, United States of America
7Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, United States of America
Find articles by Lee, C. in: JCI | PubMed | Google Scholar
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States of America
4Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan
5Jean-Pierre Aubert Research Centre, University of Lille, Lille, France
6Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, United States of America
7Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, United States of America
Find articles by Chang, Y. in: JCI | PubMed | Google Scholar |
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States of America
4Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan
5Jean-Pierre Aubert Research Centre, University of Lille, Lille, France
6Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, United States of America
7Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, United States of America
Find articles by Chen, H. in: JCI | PubMed | Google Scholar |
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States of America
4Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan
5Jean-Pierre Aubert Research Centre, University of Lille, Lille, France
6Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, United States of America
7Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, United States of America
Find articles by Nguyen, T. in: JCI | PubMed | Google Scholar
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States of America
4Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan
5Jean-Pierre Aubert Research Centre, University of Lille, Lille, France
6Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, United States of America
7Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, United States of America
Find articles by Liao, H. in: JCI | PubMed | Google Scholar
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States of America
4Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan
5Jean-Pierre Aubert Research Centre, University of Lille, Lille, France
6Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, United States of America
7Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, United States of America
Find articles by Liu, M. in: JCI | PubMed | Google Scholar
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States of America
4Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan
5Jean-Pierre Aubert Research Centre, University of Lille, Lille, France
6Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, United States of America
7Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, United States of America
Find articles by Hagar, H. in: JCI | PubMed | Google Scholar
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States of America
4Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan
5Jean-Pierre Aubert Research Centre, University of Lille, Lille, France
6Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, United States of America
7Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, United States of America
Find articles by Sun, Y. in: JCI | PubMed | Google Scholar |
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States of America
4Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan
5Jean-Pierre Aubert Research Centre, University of Lille, Lille, France
6Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, United States of America
7Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, United States of America
Find articles by Lai, H. in: JCI | PubMed | Google Scholar
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States of America
4Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan
5Jean-Pierre Aubert Research Centre, University of Lille, Lille, France
6Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, United States of America
7Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, United States of America
Find articles by Kuo, M. in: JCI | PubMed | Google Scholar
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States of America
4Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan
5Jean-Pierre Aubert Research Centre, University of Lille, Lille, France
6Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, United States of America
7Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, United States of America
Find articles by Blum, D. in: JCI | PubMed | Google Scholar |
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States of America
4Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan
5Jean-Pierre Aubert Research Centre, University of Lille, Lille, France
6Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, United States of America
7Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, United States of America
Find articles by Buée, L. in: JCI | PubMed | Google Scholar |
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States of America
4Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan
5Jean-Pierre Aubert Research Centre, University of Lille, Lille, France
6Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, United States of America
7Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, United States of America
Find articles by Jin, L. in: JCI | PubMed | Google Scholar
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States of America
4Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan
5Jean-Pierre Aubert Research Centre, University of Lille, Lille, France
6Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, United States of America
7Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, United States of America
Find articles by Chen, S. in: JCI | PubMed | Google Scholar |
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States of America
4Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan
5Jean-Pierre Aubert Research Centre, University of Lille, Lille, France
6Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, United States of America
7Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, United States of America
Find articles by Ko, T. in: JCI | PubMed | Google Scholar
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States of America
4Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan
5Jean-Pierre Aubert Research Centre, University of Lille, Lille, France
6Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, United States of America
7Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, United States of America
Find articles by Huang, J. in: JCI | PubMed | Google Scholar |
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States of America
4Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan
5Jean-Pierre Aubert Research Centre, University of Lille, Lille, France
6Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, United States of America
7Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, United States of America
Find articles by Kuo, H. in: JCI | PubMed | Google Scholar
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States of America
4Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan
5Jean-Pierre Aubert Research Centre, University of Lille, Lille, France
6Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, United States of America
7Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, United States of America
Find articles by Liu, F. in: JCI | PubMed | Google Scholar
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States of America
4Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan
5Jean-Pierre Aubert Research Centre, University of Lille, Lille, France
6Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, United States of America
7Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, United States of America
Find articles by Chern, Y. in: JCI | PubMed | Google Scholar |
Published November 21, 2023 - More info
In this episode, Yijuang Chern and Jian Jing Siew discuss the novel role of Gal3 in the regulation of extracellular vesicles, promotion of pathogenic tau fibrillation, and microglial activation.
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β plaques, aggregation of hyperphosphorylated tau (pTau), and microglia activation. Galectin-3 (Gal3) is a β-galactoside-binding protein that has been implicated in amyloid pathology. Its role in tauopathy remains enigmatic. Here, we showed that Gal3 was upregulated in the microglia of humans and mice with tauopathy. pTau triggered the release of Gal3 from human induced pluripotent stem cell-derived microglia (iMGL) in both its free and extracellular vesicular (EV)-associated forms. Both forms of Gal3 increased the accumulation of pathogenic tau in recipient cells. Binding of Gal3 to pTau greatly enhanced tau fibrillation. Besides Gal3, pTau was sorted into EVs for transmission. Moreover, pTau markedly enhanced the numbers of EVs released by iMGL in a Gal3-dependent manner, suggesting a role of Gal3 in EVs biogenesis. Single-cell RNA-seq analysis of the hippocampus of a mouse model of tauopathy (THY-Tau22) revealed a group of pathogenic tau-evoked, Gal3-associated microglia (GAM) with altered cellular machineries implicated in neurodegeneration, including enhanced immune and inflammatory responses. Genetic removal of Gal3 in THY-Tau22 mice suppressed microglia activation, reduced the level of pTau and synaptic loss in neurons, and rescued the memory impairment. Collectively, Gal3 is a potential therapeutic target for tauopathy.