Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma
Phoebe Carter, Ulrike Schnell, Christopher Chaney, Betty Tong, Xinchao Pan, Jianhua Ye, Glenda Mernaugh, Jennifer L. Cotton, Vitaly Margulis, Junhao Mao, Roy Zent, Bret M. Evers, Payal Kapur, Thomas J. Carroll
Phoebe Carter, Ulrike Schnell, Christopher Chaney, Betty Tong, Xinchao Pan, Jianhua Ye, Glenda Mernaugh, Jennifer L. Cotton, Vitaly Margulis, Junhao Mao, Roy Zent, Bret M. Evers, Payal Kapur, Thomas J. Carroll
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Research Article Cell biology Oncology

Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma

Abstract

Authors

Phoebe Carter, Ulrike Schnell, Christopher Chaney, Betty Tong, Xinchao Pan, Jianhua Ye, Glenda Mernaugh, Jennifer L. Cotton, Vitaly Margulis, Junhao Mao, Roy Zent, Bret M. Evers, Payal Kapur, Thomas J. Carroll

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Figure 2

Ablation of Lats in the proximal tubules leads to metastatic sRCC.

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Ablation of Lats in the proximal tubules leads to metastatic sRCC. (A–F)...
(A–F) H&E-stained sections of control kidney (A), control lung (E), and Slc34a1CreERT2 Lats1/2c/c kidney (B–D) and lung (F). (B) Mutant kidney 1 month after tamoxifen (n = 3). (C, D, and F) Low-magnification kidney (C), high-magnification kidney (D), and high-magnification lung (F) from Slc34a1CreERT2 Lats1/2c/c mouse 5 months after tamoxifen (n = 3). D corresponds with the box in C. Asterisk in F shows a metastasis. (G and H) Immunofluorescence staining on sections of Slc34a1CreERT2 Lats1/2c/c kidney 4 months after tamoxifen (n = 3). (G) Blue, DAPI; green, vimentin; red, Pax8; white, cytokeratin. H is a single-channel image of the image in G showing only cytokeratin. Scale bars: (A–D, G, and H) 100 μm, (E and F) 900 μm.