Clonal enrichments of Vδ2– γδ T cells in Mycobacterium tuberculosis–infected human lungs
Corinna A. Kulicke,1 Deborah A. Lewinsohn,1 and David M. Lewinsohn1,2
1Department of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA.
2Research and Development, VA Portland Health Care System, , Portland, Oregon, USA.
Address correspondence to: David Lewinsohn, Department of Pulmonary and Critical Care Medicine, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97239, USA. Phone: 503.721.1020; Email: lewinsod@ohsu.edu.
Find articles by Kulicke, C. in: JCI | PubMed | Google Scholar
1Department of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA.
2Research and Development, VA Portland Health Care System, , Portland, Oregon, USA.
Address correspondence to: David Lewinsohn, Department of Pulmonary and Critical Care Medicine, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97239, USA. Phone: 503.721.1020; Email: lewinsod@ohsu.edu.
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1Department of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA.
2Research and Development, VA Portland Health Care System, , Portland, Oregon, USA.
Address correspondence to: David Lewinsohn, Department of Pulmonary and Critical Care Medicine, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97239, USA. Phone: 503.721.1020; Email: lewinsod@ohsu.edu.
Find articles by
Lewinsohn, D.
in:
JCI
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PubMed
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First published November 25, 2019 - More info
J Clin Invest. 2020;130(1):68–70. https://doi.org/10.1172/JCI133119.
© 2020 American Society for Clinical Investigation
Unconventional T cell subsets, including donor-unrestricted T cells (DURTs) and γδ T cells, are promising new players in the treatment and prevention of infectious diseases. In this issue of the JCI, Ogongo et al. used T cell receptor (TCR) sequencing to characterize unconventional T cell subsets in surgical lung resections and blood from Mycobacterium tuberculosis–infected (Mtb-infected) individuals with and without HIV coinfection. The study revealed highly localized expansions of γδ T cell clonotypes not previously associated with the immune response to Mtb and demonstrates the power of high-throughput analysis of the TCR repertoire directly from infected tissue. The findings contribute to our understanding of tuberculosis control and have implications for the development of both therapeutic and vaccination strategies.
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