Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Address correspondence to: Richard F. Ambinder, Department of Oncology, Johns Hopkins School of Medicine, Cancer Research Building, Room 389, 1650 Orleans Street, Baltimore, Maryland 21287, USA. Phone: 410.955.8839; Email: firstname.lastname@example.org.
First published May 7, 2018 - More info
The human gammaherpesviruses, Epstein-Barr virus (EBV) and Kaposi’s sarcoma–associated herpesvirus (KSHV), are both associated with tumors. Standard antiviral therapies are ineffective at treating these tumors. A serine/threonine kinase important for viral replication is conserved across the herpesviruses. Expression of the KSHV protein kinase in transgenic mice under the control of a ubiquitin promoter was associated with B cell lymphoproliferative disease and lymphoma. If the viral protein kinase is important in the pathogenesis of KSHV lymphoproliferative disease or lymphoma, the kinase may present a very good target for pharmacologic therapies.
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