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Usage Information

A viral protein kinase drug target for tumors?
Richard F. Ambinder
Richard F. Ambinder
Published May 7, 2018
Citation Information: J Clin Invest. 2018;128(6):2197-2198. https://doi.org/10.1172/JCI121080.
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Commentary

A viral protein kinase drug target for tumors?

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Abstract

The human gammaherpesviruses, Epstein-Barr virus (EBV) and Kaposi’s sarcoma–associated herpesvirus (KSHV), are both associated with tumors. Standard antiviral therapies are ineffective at treating these tumors. A serine/threonine kinase important for viral replication is conserved across the herpesviruses. Expression of the KSHV protein kinase in transgenic mice under the control of a ubiquitin promoter was associated with B cell lymphoproliferative disease and lymphoma. If the viral protein kinase is important in the pathogenesis of KSHV lymphoproliferative disease or lymphoma, the kinase may present a very good target for pharmacologic therapies.

Authors

Richard F. Ambinder

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