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Research Article Free access | 10.1172/JCI112792

Steroid-sensitive mechanism of soluble immune response suppressor production in steroid-responsive nephrotic syndrome.

H W Schnaper and T M Aune

Find articles by Schnaper, H. in: PubMed | Google Scholar

Find articles by Aune, T. in: PubMed | Google Scholar

Published January 1, 1987 - More info

Published in Volume 79, Issue 1 on January 1, 1987
J Clin Invest. 1987;79(1):257–264. https://doi.org/10.1172/JCI112792.
© 1987 The American Society for Clinical Investigation
Published January 1, 1987 - Version history
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Abstract

Soluble immune response suppressor (SIRS), a lymphokine that suppresses antibody production and delayed type hypersensitivity in vivo, has been detected in urine and serum from certain patients with nephrotic syndrome. In the present paper, the relationship between SIRS production and nephrotic syndrome is further characterized. A striking correlation was found between detection of SIRS and the presence of steroid-responsive nephrotic syndrome (SRNS). A potential mechanism of SIRS production in SRNS patients was identified, in that lymphocytes from patients produced SIRS without requiring activation by exogenous agents, and incubation of normal lymphocytes with serum from patients activated the cells to secrete SIRS in culture. Although SIRS disappears rapidly from urine or serum after initiation of corticosteroid therapy, hydrocortisone (10(-6)-10(-7) M) did not block secretion of SIRS by activated suppressor cells. It did, however, inhibit in vitro activation of lymphocytes to produce SIRS by concanavalin A, interferon, or SRNS patient serum. The association of suppressor cell activation with SRNS and the sensitivity of both to steroids suggest that the pathogeneses of albuminuria and SIRS production are related.

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