Effects of vitamin A deficiency and repletion on rat insulin secretion in vivo and in vitro from isolated islets.

B S Chertow; W S Blaner; N G Baranetsky; W I Sivitz; M B Cordle; D Thompson; P Meda

doi:10.1172/JCI112778

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Published in Volume 79, Issue 1 on January 1, 1987
J Clin Invest. 1987;79(1):163–169. https://doi.org/10.1172/JCI112778.
© 1987 The American Society for Clinical Investigation

Published January 1, 1987 - Version history

We studied the effects of vitamin A deficiency and repletion on rat insulin release and islet cellular retinol binding protein (CRBP) and cellular retinoic acid binding protein (CRABP). Biphasic insulin release from vitamin A-deficient perifused islets was markedly impaired. Release remained impaired with retinoic acid (RA) repletion, 2 micrograms/g diet compared to release from islets of rats repleted with retinol in the form of retinyl palmitate, 4 micrograms/g diet. Release normalized with RA, 8 micrograms/g diet. Vitamin A deficiency did not affect islet insulin content, cell size, number or structure. In vivo, vitamin A-deficient rats had impaired glucose-induced acute insulin release and glucose intolerance, which improved with repletion. Normal islets had greater concentrations of CRBP than CRABP; vitamin A deficiency reduced CRBP but not CRABP levels. We conclude retinol is required for normal insulin secretion. Retinoic acid may substitute for retinol in this function.

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Effects of vitamin A deficiency and repletion on rat insulin secretion in vivo and in vitro from isolated islets.

B S Chertow, W S Blaner, N G Baranetsky, W I Sivitz, M B Cordle, D Thompson, and P Meda

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Effects of vitamin A deficiency and repletion on rat insulin secretion in vivo and in vitro from isolated islets.

B S Chertow, W S Blaner, N G Baranetsky, W I Sivitz, M B Cordle, D Thompson, and P Meda

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