Issue published July 15, 1997 Previous issue | Next issue
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Research Articles
W Ling, … , T Kodama, U P SteinbrecherW Ling, … , T Kodama, U P SteinbrecherPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):244-252. https://doi.org/10.1172/JCI119528.×Abstract
Research Article
Authors
W Ling, M Lougheed, H Suzuki, A Buchan, T Kodama, U P Steinbrecher
L J Dell'Italia, … , G H Hankes, S OparilL J Dell'Italia, … , G H Hankes, S OparilPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):253-258. https://doi.org/10.1172/JCI119529.×Abstract
Research Article
Authors
L J Dell'Italia, Q C Meng, E Balcells, C C Wei, R Palmer, G R Hageman, J Durand, G H Hankes, S Oparil
A G Uitterlinden, … , J P van Leeuwen, H A PolsA G Uitterlinden, … , J P van Leeuwen, H A PolsPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):259-263. https://doi.org/10.1172/JCI119530.×Abstract
Research Article
Authors
A G Uitterlinden, H Burger, Q Huang, E Odding, C M Duijn, A Hofman, J C Birkenhäger, J P van Leeuwen, H A Pols
H M Siragy, R M CareyH M Siragy, R M CareyPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):264-269. https://doi.org/10.1172/JCI119531.×Abstract
Research Article
Authors
H M Siragy, R M Carey
W G Haynes, … , A L Mark, W I SivitzW G Haynes, … , A L Mark, W I SivitzPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):270-278. https://doi.org/10.1172/JCI119532.×Abstract
Research Article
Authors
W G Haynes, D A Morgan, S A Walsh, A L Mark, W I Sivitz
R M Zwacka, … , L Dudus, J F EngelhardtR M Zwacka, … , L Dudus, J F EngelhardtPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):279-289. https://doi.org/10.1172/JCI119533.×Abstract
Research Article
Authors
R M Zwacka, Y Zhang, J Halldorson, H Schlossberg, L Dudus, J F Engelhardt
M Shimabukuro, … , Y Lee, R H UngerM Shimabukuro, … , Y Lee, R H UngerPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):290-295. https://doi.org/10.1172/JCI119534.×Abstract
Research Article
Authors
M Shimabukuro, M Ohneda, Y Lee, R H Unger
L Eckmann, … , J R Smith, M F KagnoffL Eckmann, … , J R Smith, M F KagnoffPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):296-309. https://doi.org/10.1172/JCI119535.×Abstract
Research Article
Authors
L Eckmann, W F Stenson, T C Savidge, D C Lowe, K E Barrett, J Fierer, J R Smith, M F Kagnoff
Frank M. LaFerla, … , Claudia H. Kawas, Gilbert JayFrank M. LaFerla, … , Claudia H. Kawas, Gilbert JayPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):310-320. https://doi.org/10.1172/JCI119536.×Abstract
The brains of individuals with Alzheimer's disease (AD) are characterized by extracellular deposition of beta-amyloid protein (Abeta), intracellular neurofibrillary tangles, and loss of neurons. To study molecular markers associated with dying cells in the AD brain, in situ DNA labeling techniques were used to visualize cells with DNA fragmentation. We observed that intracellular accumulation of apolipoprotein E (apoE) is correlated with the detection of intracellular Abeta-like immunoreactivity within the same cytoplasmic granules, suggesting that uptake of lipids may have stabilized the hydrophobic Abeta protein within the cell. These apoE-containing neurons also exhibit high expression of a cell surface receptor, gp330, which is known to bind apoE. Cells containing significant nuclear DNA fragmentation express the highest level of cell surface gp330. Extracellular deposition of Abeta is detected only upon neuronal cell death, initially as halos of Abeta immunoreactivity around individual dying neurons, and subsequently as Abeta plaques containing numerous neuronal cell ghosts. Based on our in situ analysis of nuclear DNA fragmentation, we conclude that neuronal cell death likely occurs before the extracellular deposition of Abeta in AD brains.
Authors
Frank M. LaFerla, Juan C. Troncoso, Dudley K. Strickland, Claudia H. Kawas, Gilbert Jay
N M Wolfman, … , J M Wozney, V RosenN M Wolfman, … , J M Wozney, V RosenPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):321-330. https://doi.org/10.1172/JCI119537.×Abstract
Research Article
Authors
N M Wolfman, G Hattersley, K Cox, A J Celeste, R Nelson, N Yamaji, J L Dube, E DiBlasio-Smith, J Nove, J J Song, J M Wozney, V Rosen
P Jäkälä, … , A Mannermaa, H SoininenP Jäkälä, … , A Mannermaa, H SoininenPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):331-338. https://doi.org/10.1172/JCI119538.×Fragile-X: neuropsychological test performance, CGG triplet repeat lengths, and hippocampal volumes.
Abstract
Research Article
Authors
P Jäkälä, T Hänninen, M Ryynänen, M Laakso, K Partanen, A Mannermaa, H Soininen
P A Muraro, … , H F McFarland, R MartinP A Muraro, … , H F McFarland, R MartinPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):339-349. https://doi.org/10.1172/JCI119539.×Abstract
Research Article
Authors
P A Muraro, M Vergelli, M Kalbus, D E Banks, J W Nagle, L R Tranquill, G T Nepom, W E Biddison, H F McFarland, R Martin
J E Freedman, … , J F Keaney, A D MichelsonJ E Freedman, … , J F Keaney, A D MichelsonPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):350-356. https://doi.org/10.1172/JCI119540.×Abstract
Research Article
Authors
J E Freedman, J Loscalzo, M R Barnard, C Alpert, J F Keaney, A D Michelson
I Shimon, … , D W Ray, S MelmedI Shimon, … , D W Ray, S MelmedPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):357-363. https://doi.org/10.1172/JCI119541.×Abstract
Research Article
Authors
I Shimon, X Yan, D W Ray, S Melmed
M Söderhäll, … , J Winberg, R MöllbyM Söderhäll, … , J Winberg, R MöllbyPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):364-372. https://doi.org/10.1172/JCI119542.×Abstract
Research Article
Authors
M Söderhäll, S Normark, K Ishikawa, K Karlsson, S Teneberg, J Winberg, R Möllby
H Okuda, … , Y Okubo, E KajiiH Okuda, … , Y Okubo, E KajiiPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):373-379. https://doi.org/10.1172/JCI119543.×Abstract
Research Article
Authors
H Okuda, M Kawano, S Iwamoto, M Tanaka, T Seno, Y Okubo, E Kajii
H He, … , E Swanson, W H DillmannH He, … , E Swanson, W H DillmannPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):380-389. https://doi.org/10.1172/JCI119544.×Abstract
Research Article
Authors
H He, F J Giordano, R Hilal-Dandan, D J Choi, H A Rockman, P M McDonough, W F Bluhm, M Meyer, M R Sayen, E Swanson, W H Dillmann
P Gressens, … , M Fridkin, P EvrardP Gressens, … , M Fridkin, P EvrardPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):390-397. https://doi.org/10.1172/JCI119545.×Abstract
Research Article
Authors
P Gressens, S Marret, J M Hill, D E Brenneman, I Gozes, M Fridkin, P Evrard
D T Stein, … , S D Turley, J D McGarryD T Stein, … , S D Turley, J D McGarryPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):398-403. https://doi.org/10.1172/JCI119546.×Abstract
Research Article
Authors
D T Stein, B E Stevenson, M W Chester, M Basit, M B Daniels, S D Turley, J D McGarry
D C Chung, … , A L Warshaw, A ArnoldD C Chung, … , A L Warshaw, A ArnoldPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):404-410. https://doi.org/10.1172/JCI119547.×Abstract
Research Article
Authors
D C Chung, A P Smith, D N Louis, F Graeme-Cook, A L Warshaw, A Arnold
S Kurosawa, … , N Hidari, C T EsmonS Kurosawa, … , N Hidari, C T EsmonPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):411-418. https://doi.org/10.1172/JCI119548.×Abstract
Research Article
Authors
S Kurosawa, D J Stearns-Kurosawa, N Hidari, C T Esmon
R Singh, … , M Konieczkowski, J R SedorR Singh, … , M Konieczkowski, J R SedorPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):419-428. https://doi.org/10.1172/JCI119549.×Abstract
Research Article
Authors
R Singh, S Huang, T Guth, M Konieczkowski, J R Sedor
S N Davis, … , B Davis, F CostaS N Davis, … , B Davis, F CostaPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):429-438. https://doi.org/10.1172/JCI119550.×Abstract
Research Article
Authors
S N Davis, C Shavers, B Davis, F Costa
D Schwartz, … , C B Wilson, R C BlantzD Schwartz, … , C B Wilson, R C BlantzPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):439-448. https://doi.org/10.1172/JCI119551.×Abstract
Research Article
Authors
D Schwartz, M Mendonca, I Schwartz, Y Xia, J Satriano, C B Wilson, R C Blantz
F Ahmad, … , G L Dohm, B J GoldsteinF Ahmad, … , G L Dohm, B J GoldsteinPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):449-458. https://doi.org/10.1172/JCI119552.×Abstract
Research Article
Authors
F Ahmad, J L Azevedo, R Cortright, G L Dohm, B J Goldstein
J A van Roon, … , F J Lafeber, J W BijlsmaJ A van Roon, … , F J Lafeber, J W BijlsmaPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):459-463. https://doi.org/10.1172/JCI119553.×Abstract
Research Article
Authors
J A van Roon, W van Eden, J L van Roy, F J Lafeber, J W Bijlsma
L W Castellani, … , A M Fogelman, A J LusisL W Castellani, … , A M Fogelman, A J LusisPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):464-474. https://doi.org/10.1172/JCI119554.×Abstract
Research Article
Authors
L W Castellani, M Navab, B J Van Lenten, C C Hedrick, S Y Hama, A M Goto, A M Fogelman, A J Lusis
W Rottbauer, … , W Kübler, H A KatusW Rottbauer, … , W Kübler, H A KatusPublished July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):475-482. https://doi.org/10.1172/JCI119555.×Abstract
Research Article
Authors
W Rottbauer, M Gautel, J Zehelein, S Labeit, W M Franz, C Fischer, B Vollrath, G Mall, R Dietz, W Kübler, H A Katus
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