Issue published July 15, 1997 Previous issue | Next issue

  • Volume 100, Issue 2
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Perspective
Perspectives series: host/pathogen interactions. Invasion and intracellular sorting of bacteria: searching for bacterial genes expressed during host/pathogen interactions.
S Falkow
S Falkow
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Research Articles
Oxidized or acetylated low density lipoproteins are rapidly cleared by the liver in mice with disruption of the scavenger receptor class A type I/II gene.
W Ling, M Lougheed, H Suzuki, A Buchan, T Kodama, U P Steinbrecher
W Ling, M Lougheed, H Suzuki, A Buchan, T Kodama, U P Steinbrecher
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Compartmentalization of angiotensin II generation in the dog heart. Evidence for independent mechanisms in intravascular and interstitial spaces.
L J Dell'Italia, Q C Meng, E Balcells, C C Wei, R Palmer, G R Hageman, J Durand, G H Hankes, S Oparil
L J Dell'Italia, Q C Meng, E Balcells, C C Wei, R Palmer, G R Hageman, J Durand, G H Hankes, S Oparil
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Compartmentalization of angiotensin II generation in the dog heart. Evidence for independent mechanisms in intravascular and interstitial spaces.

Abstract

Research Article

Authors

L J Dell'Italia, Q C Meng, E Balcells, C C Wei, R Palmer, G R Hageman, J Durand, G H Hankes, S Oparil

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Vitamin D receptor genotype is associated with radiographic osteoarthritis at the knee.
A G Uitterlinden, H Burger, Q Huang, E Odding, C M Duijn, A Hofman, J C Birkenhäger, J P van Leeuwen, H A Pols
A G Uitterlinden, H Burger, Q Huang, E Odding, C M Duijn, A Hofman, J C Birkenhäger, J P van Leeuwen, H A Pols
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Vitamin D receptor genotype is associated with radiographic osteoarthritis at the knee.

Abstract

Research Article

Authors

A G Uitterlinden, H Burger, Q Huang, E Odding, C M Duijn, A Hofman, J C Birkenhäger, J P van Leeuwen, H A Pols

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The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats.
H M Siragy, R M Carey
H M Siragy, R M Carey
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Receptor-mediated regional sympathetic nerve activation by leptin.
W G Haynes, D A Morgan, S A Walsh, A L Mark, W I Sivitz
W G Haynes, D A Morgan, S A Walsh, A L Mark, W I Sivitz
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Receptor-mediated regional sympathetic nerve activation by leptin.

Abstract

Research Article

Authors

W G Haynes, D A Morgan, S A Walsh, A L Mark, W I Sivitz

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CD4(+) T-lymphocytes mediate ischemia/reperfusion-induced inflammatory responses in mouse liver.
R M Zwacka, Y Zhang, J Halldorson, H Schlossberg, L Dudus, J F Engelhardt
R M Zwacka, Y Zhang, J Halldorson, H Schlossberg, L Dudus, J F Engelhardt
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CD4(+) T-lymphocytes mediate ischemia/reperfusion-induced inflammatory responses in mouse liver.

Abstract

Research Article

Authors

R M Zwacka, Y Zhang, J Halldorson, H Schlossberg, L Dudus, J F Engelhardt

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Role of nitric oxide in obesity-induced beta cell disease.
M Shimabukuro, M Ohneda, Y Lee, R H Unger
M Shimabukuro, M Ohneda, Y Lee, R H Unger
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Role of nitric oxide in obesity-induced beta cell disease.

Abstract

Research Article

Authors

M Shimabukuro, M Ohneda, Y Lee, R H Unger

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Role of intestinal epithelial cells in the host secretory response to infection by invasive bacteria. Bacterial entry induces epithelial prostaglandin h synthase-2 expression and prostaglandin E2 and F2alpha production.
L Eckmann, W F Stenson, T C Savidge, D C Lowe, K E Barrett, J Fierer, J R Smith, M F Kagnoff
L Eckmann, W F Stenson, T C Savidge, D C Lowe, K E Barrett, J Fierer, J R Smith, M F Kagnoff
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Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization.
Frank M. LaFerla, Juan C. Troncoso, Dudley K. Strickland, Claudia H. Kawas, Gilbert Jay
Frank M. LaFerla, Juan C. Troncoso, Dudley K. Strickland, Claudia H. Kawas, Gilbert Jay
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Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization.

Abstract

The brains of individuals with Alzheimer's disease (AD) are characterized by extracellular deposition of beta-amyloid protein (Abeta), intracellular neurofibrillary tangles, and loss of neurons. To study molecular markers associated with dying cells in the AD brain, in situ DNA labeling techniques were used to visualize cells with DNA fragmentation. We observed that intracellular accumulation of apolipoprotein E (apoE) is correlated with the detection of intracellular Abeta-like immunoreactivity within the same cytoplasmic granules, suggesting that uptake of lipids may have stabilized the hydrophobic Abeta protein within the cell. These apoE-containing neurons also exhibit high expression of a cell surface receptor, gp330, which is known to bind apoE. Cells containing significant nuclear DNA fragmentation express the highest level of cell surface gp330. Extracellular deposition of Abeta is detected only upon neuronal cell death, initially as halos of Abeta immunoreactivity around individual dying neurons, and subsequently as Abeta plaques containing numerous neuronal cell ghosts. Based on our in situ analysis of nuclear DNA fragmentation, we conclude that neuronal cell death likely occurs before the extracellular deposition of Abeta in AD brains.

Authors

Frank M. LaFerla, Juan C. Troncoso, Dudley K. Strickland, Claudia H. Kawas, Gilbert Jay

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Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family.
N M Wolfman, G Hattersley, K Cox, A J Celeste, R Nelson, N Yamaji, J L Dube, E DiBlasio-Smith, J Nove, J J Song, J M Wozney, V Rosen
N M Wolfman, G Hattersley, K Cox, A J Celeste, R Nelson, N Yamaji, J L Dube, E DiBlasio-Smith, J Nove, J J Song, J M Wozney, V Rosen
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Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family.

Abstract

Research Article

Authors

N M Wolfman, G Hattersley, K Cox, A J Celeste, R Nelson, N Yamaji, J L Dube, E DiBlasio-Smith, J Nove, J J Song, J M Wozney, V Rosen

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Fragile-X: neuropsychological test performance, CGG triplet repeat lengths, and hippocampal volumes.
P Jäkälä, T Hänninen, M Ryynänen, M Laakso, K Partanen, A Mannermaa, H Soininen
P Jäkälä, T Hänninen, M Ryynänen, M Laakso, K Partanen, A Mannermaa, H Soininen
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Fragile-X: neuropsychological test performance, CGG triplet repeat lengths, and hippocampal volumes.

Abstract

Research Article

Authors

P Jäkälä, T Hänninen, M Ryynänen, M Laakso, K Partanen, A Mannermaa, H Soininen

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Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire.
P A Muraro, M Vergelli, M Kalbus, D E Banks, J W Nagle, L R Tranquill, G T Nepom, W E Biddison, H F McFarland, R Martin
P A Muraro, M Vergelli, M Kalbus, D E Banks, J W Nagle, L R Tranquill, G T Nepom, W E Biddison, H F McFarland, R Martin
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Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire.

Abstract

Research Article

Authors

P A Muraro, M Vergelli, M Kalbus, D E Banks, J W Nagle, L R Tranquill, G T Nepom, W E Biddison, H F McFarland, R Martin

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Nitric oxide released from activated platelets inhibits platelet recruitment.
J E Freedman, J Loscalzo, M R Barnard, C Alpert, J F Keaney, A D Michelson
J E Freedman, J Loscalzo, M R Barnard, C Alpert, J F Keaney, A D Michelson
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Nitric oxide released from activated platelets inhibits platelet recruitment.

Abstract

Research Article

Authors

J E Freedman, J Loscalzo, M R Barnard, C Alpert, J F Keaney, A D Michelson

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Cytokine-dependent gp130 receptor subunit regulates human fetal pituitary adrenocorticotropin hormone and growth hormone secretion.
I Shimon, X Yan, D W Ray, S Melmed
I Shimon, X Yan, D W Ray, S Melmed
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Induction of protective immunity after escherichia coli bladder infection in primates. Dependence of the globoside-specific P-fimbrial tip adhesin and its cognate receptor.
M Söderhäll, S Normark, K Ishikawa, K Karlsson, S Teneberg, J Winberg, R Möllby
M Söderhäll, S Normark, K Ishikawa, K Karlsson, S Teneberg, J Winberg, R Möllby
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Induction of protective immunity after escherichia coli bladder infection in primates. Dependence of the globoside-specific P-fimbrial tip adhesin and its cognate receptor.

Abstract

Research Article

Authors

M Söderhäll, S Normark, K Ishikawa, K Karlsson, S Teneberg, J Winberg, R Möllby

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The RHD gene is highly detectable in RhD-negative Japanese donors.
H Okuda, M Kawano, S Iwamoto, M Tanaka, T Seno, Y Okubo, E Kajii
H Okuda, M Kawano, S Iwamoto, M Tanaka, T Seno, Y Okubo, E Kajii
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The RHD gene is highly detectable in RhD-negative Japanese donors.

Abstract

Research Article

Authors

H Okuda, M Kawano, S Iwamoto, M Tanaka, T Seno, Y Okubo, E Kajii

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Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation.
H He, F J Giordano, R Hilal-Dandan, D J Choi, H A Rockman, P M McDonough, W F Bluhm, M Meyer, M R Sayen, E Swanson, W H Dillmann
H He, F J Giordano, R Hilal-Dandan, D J Choi, H A Rockman, P M McDonough, W F Bluhm, M Meyer, M R Sayen, E Swanson, W H Dillmann
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Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation.

Abstract

Research Article

Authors

H He, F J Giordano, R Hilal-Dandan, D J Choi, H A Rockman, P M McDonough, W F Bluhm, M Meyer, M R Sayen, E Swanson, W H Dillmann

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Vasoactive intestinal peptide prevents excitotoxic cell death in the murine developing brain.
P Gressens, S Marret, J M Hill, D E Brenneman, I Gozes, M Fridkin, P Evrard
P Gressens, S Marret, J M Hill, D E Brenneman, I Gozes, M Fridkin, P Evrard
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Vasoactive intestinal peptide prevents excitotoxic cell death in the murine developing brain.

Abstract

Research Article

Authors

P Gressens, S Marret, J M Hill, D E Brenneman, I Gozes, M Fridkin, P Evrard

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The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation.
D T Stein, B E Stevenson, M W Chester, M Basit, M B Daniels, S D Turley, J D McGarry
D T Stein, B E Stevenson, M W Chester, M Basit, M B Daniels, S D Turley, J D McGarry
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The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation.

Abstract

Research Article

Authors

D T Stein, B E Stevenson, M W Chester, M Basit, M B Daniels, S D Turley, J D McGarry

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A novel pancreatic endocrine tumor suppressor gene locus on chromosome 3p with clinical prognostic implications.
D C Chung, A P Smith, D N Louis, F Graeme-Cook, A L Warshaw, A Arnold
D C Chung, A P Smith, D N Louis, F Graeme-Cook, A L Warshaw, A Arnold
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A novel pancreatic endocrine tumor suppressor gene locus on chromosome 3p with clinical prognostic implications.

Abstract

Research Article

Authors

D C Chung, A P Smith, D N Louis, F Graeme-Cook, A L Warshaw, A Arnold

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Identification of functional endothelial protein C receptor in human plasma.
S Kurosawa, D J Stearns-Kurosawa, N Hidari, C T Esmon
S Kurosawa, D J Stearns-Kurosawa, N Hidari, C T Esmon
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Identification of functional endothelial protein C receptor in human plasma.

Abstract

Research Article

Authors

S Kurosawa, D J Stearns-Kurosawa, N Hidari, C T Esmon

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Cytosolic domain of the type I interleukin-1 receptor spontaneously recruits signaling molecules to activate a proinflammatory gene.
R Singh, S Huang, T Guth, M Konieczkowski, J R Sedor
R Singh, S Huang, T Guth, M Konieczkowski, J R Sedor
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Prevention of an increase in plasma cortisol during hypoglycemia preserves subsequent counterregulatory responses.
S N Davis, C Shavers, B Davis, F Costa
S N Davis, C Shavers, B Davis, F Costa
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Inhibition of constitutive nitric oxide synthase (NOS) by nitric oxide generated by inducible NOS after lipopolysaccharide administration provokes renal dysfunction in rats.
D Schwartz, M Mendonca, I Schwartz, Y Xia, J Satriano, C B Wilson, R C Blantz
D Schwartz, M Mendonca, I Schwartz, Y Xia, J Satriano, C B Wilson, R C Blantz
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Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes.
F Ahmad, J L Azevedo, R Cortright, G L Dohm, B J Goldstein
F Ahmad, J L Azevedo, R Cortright, G L Dohm, B J Goldstein
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Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes.

Abstract

Research Article

Authors

F Ahmad, J L Azevedo, R Cortright, G L Dohm, B J Goldstein

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Stimulation of suppressive T cell responses by human but not bacterial 60-kD heat-shock protein in synovial fluid of patients with rheumatoid arthritis.
J A van Roon, W van Eden, J L van Roy, F J Lafeber, J W Bijlsma
J A van Roon, W van Eden, J L van Roy, F J Lafeber, J W Bijlsma
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Overexpression of apolipoprotein AII in transgenic mice converts high density lipoproteins to proinflammatory particles.
L W Castellani, M Navab, B J Van Lenten, C C Hedrick, S Y Hama, A M Goto, A M Fogelman, A J Lusis
L W Castellani, M Navab, B J Van Lenten, C C Hedrick, S Y Hama, A M Goto, A M Fogelman, A J Lusis
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Overexpression of apolipoprotein AII in transgenic mice converts high density lipoproteins to proinflammatory particles.

Abstract

Research Article

Authors

L W Castellani, M Navab, B J Van Lenten, C C Hedrick, S Y Hama, A M Goto, A M Fogelman, A J Lusis

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Novel splice donor site mutation in the cardiac myosin-binding protein-C gene in familial hypertrophic cardiomyopathy. Characterization Of cardiac transcript and protein.
W Rottbauer, M Gautel, J Zehelein, S Labeit, W M Franz, C Fischer, B Vollrath, G Mall, R Dietz, W Kübler, H A Katus
W Rottbauer, M Gautel, J Zehelein, S Labeit, W M Franz, C Fischer, B Vollrath, G Mall, R Dietz, W Kübler, H A Katus
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Novel splice donor site mutation in the cardiac myosin-binding protein-C gene in familial hypertrophic cardiomyopathy. Characterization Of cardiac transcript and protein.

Abstract

Research Article

Authors

W Rottbauer, M Gautel, J Zehelein, S Labeit, W M Franz, C Fischer, B Vollrath, G Mall, R Dietz, W Kübler, H A Katus

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