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Video abstracts

In this video collection, authors of findings published in The Journal of Clinical Investigation present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Video Abstracts Guidelines page.

N-cadherin upregulation in glioblastoma

In this episode, Erwin Van Meir and Satoru Osuka eplain that glioma stem cells adapt to the toxicity of repeated irradiation by upregulating N-cadherin, and this resistance pathway can be antagonized by blocking the IGF1 receptor.


Protecting kidney from fibrosis by enhancing fatty acid oxidation

In this episode, Santiago Lamas and Verónica Miguel explain that strategies based on FAO-GOF may constitute powerful alternatives to combat fibrosis inherent to CKD.


Targeting a Braf/Mapk pathway in CoQ-deficiency kidney disease

In this episode, Ana Greka and Eriene-Heidi Sidhom explain that an investigation of cell-specific disease mechanisms in rare genetic disorder revealed Braf/Mapk as a candidate pathway for the treatment of kidney diseases.


The COVID-19 immune landscape correlation with disease severity

In this episode, Jane Buckner explains a longitudinal analysis of acute COVID-19 ranging from mild to severe disease determining immune trajectories of recovery.


Variant increases ER chaperones GRP78 and GRP94 and protects against liver injury

In this episode, Richard Austin, Paul Lebeau, and Michel Chrétien explain that the human Q152H ProPCSK9 mutation acquires an unexpected novel function: protection against ER stress and liver injury by enhancing chaperone expression.

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