Advertisement
ResearchIn-Press PreviewNephrology Free access | 10.1172/JCI140695
1Program of Physiological and Pathological Processes, Centro de Biología Molecular “Severo Ochoa", Madrid, Spain
2Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain
3Centre for Metabolomics and Bioanalysis, Universidad San Pablo-CEU, Madrid, Spain
4Department of Medicine and Medical Specialties, Alcalá University, Madrid, Spain
5Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Fundación Jiménez Díaz-Universidad Autónoma Madrid, Madrid, Spain
6University Hospital, Alcalá de Henares, Madrid, Spain
7Division of Nephrology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Department of Preventive Medicine and Public Health, University of Navarra, Pampona, Spain
9Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain
10Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
11Transgenics Unit, Spanish National Cancer Research Centre, Madrid, Spain
12Genomic Facility, Parque Científico de Madrid, Madrid, Spain
Find articles by Miguel, V. in: JCI | PubMed | Google Scholar
1Program of Physiological and Pathological Processes, Centro de Biología Molecular “Severo Ochoa", Madrid, Spain
2Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain
3Centre for Metabolomics and Bioanalysis, Universidad San Pablo-CEU, Madrid, Spain
4Department of Medicine and Medical Specialties, Alcalá University, Madrid, Spain
5Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Fundación Jiménez Díaz-Universidad Autónoma Madrid, Madrid, Spain
6University Hospital, Alcalá de Henares, Madrid, Spain
7Division of Nephrology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Department of Preventive Medicine and Public Health, University of Navarra, Pampona, Spain
9Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain
10Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
11Transgenics Unit, Spanish National Cancer Research Centre, Madrid, Spain
12Genomic Facility, Parque Científico de Madrid, Madrid, Spain
Find articles by Tituaña, J. in: JCI | PubMed | Google Scholar
1Program of Physiological and Pathological Processes, Centro de Biología Molecular “Severo Ochoa", Madrid, Spain
2Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain
3Centre for Metabolomics and Bioanalysis, Universidad San Pablo-CEU, Madrid, Spain
4Department of Medicine and Medical Specialties, Alcalá University, Madrid, Spain
5Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Fundación Jiménez Díaz-Universidad Autónoma Madrid, Madrid, Spain
6University Hospital, Alcalá de Henares, Madrid, Spain
7Division of Nephrology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Department of Preventive Medicine and Public Health, University of Navarra, Pampona, Spain
9Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain
10Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
11Transgenics Unit, Spanish National Cancer Research Centre, Madrid, Spain
12Genomic Facility, Parque Científico de Madrid, Madrid, Spain
Find articles by Herrero, J. in: JCI | PubMed | Google Scholar
1Program of Physiological and Pathological Processes, Centro de Biología Molecular “Severo Ochoa", Madrid, Spain
2Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain
3Centre for Metabolomics and Bioanalysis, Universidad San Pablo-CEU, Madrid, Spain
4Department of Medicine and Medical Specialties, Alcalá University, Madrid, Spain
5Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Fundación Jiménez Díaz-Universidad Autónoma Madrid, Madrid, Spain
6University Hospital, Alcalá de Henares, Madrid, Spain
7Division of Nephrology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Department of Preventive Medicine and Public Health, University of Navarra, Pampona, Spain
9Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain
10Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
11Transgenics Unit, Spanish National Cancer Research Centre, Madrid, Spain
12Genomic Facility, Parque Científico de Madrid, Madrid, Spain
Find articles by
Herrero, L.
in:
JCI
|
PubMed
|
Google Scholar
|
1Program of Physiological and Pathological Processes, Centro de Biología Molecular “Severo Ochoa", Madrid, Spain
2Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain
3Centre for Metabolomics and Bioanalysis, Universidad San Pablo-CEU, Madrid, Spain
4Department of Medicine and Medical Specialties, Alcalá University, Madrid, Spain
5Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Fundación Jiménez Díaz-Universidad Autónoma Madrid, Madrid, Spain
6University Hospital, Alcalá de Henares, Madrid, Spain
7Division of Nephrology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Department of Preventive Medicine and Public Health, University of Navarra, Pampona, Spain
9Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain
10Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
11Transgenics Unit, Spanish National Cancer Research Centre, Madrid, Spain
12Genomic Facility, Parque Científico de Madrid, Madrid, Spain
Find articles by
Serra, D.
in:
JCI
|
PubMed
|
Google Scholar
|
1Program of Physiological and Pathological Processes, Centro de Biología Molecular “Severo Ochoa", Madrid, Spain
2Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain
3Centre for Metabolomics and Bioanalysis, Universidad San Pablo-CEU, Madrid, Spain
4Department of Medicine and Medical Specialties, Alcalá University, Madrid, Spain
5Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Fundación Jiménez Díaz-Universidad Autónoma Madrid, Madrid, Spain
6University Hospital, Alcalá de Henares, Madrid, Spain
7Division of Nephrology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Department of Preventive Medicine and Public Health, University of Navarra, Pampona, Spain
9Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain
10Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
11Transgenics Unit, Spanish National Cancer Research Centre, Madrid, Spain
12Genomic Facility, Parque Científico de Madrid, Madrid, Spain
Find articles by Cuevas-Delgado, P. in: JCI | PubMed | Google Scholar
1Program of Physiological and Pathological Processes, Centro de Biología Molecular “Severo Ochoa", Madrid, Spain
2Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain
3Centre for Metabolomics and Bioanalysis, Universidad San Pablo-CEU, Madrid, Spain
4Department of Medicine and Medical Specialties, Alcalá University, Madrid, Spain
5Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Fundación Jiménez Díaz-Universidad Autónoma Madrid, Madrid, Spain
6University Hospital, Alcalá de Henares, Madrid, Spain
7Division of Nephrology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Department of Preventive Medicine and Public Health, University of Navarra, Pampona, Spain
9Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain
10Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
11Transgenics Unit, Spanish National Cancer Research Centre, Madrid, Spain
12Genomic Facility, Parque Científico de Madrid, Madrid, Spain
Find articles by
Barbas, C.
in:
JCI
|
PubMed
|
Google Scholar
|
1Program of Physiological and Pathological Processes, Centro de Biología Molecular “Severo Ochoa", Madrid, Spain
2Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain
3Centre for Metabolomics and Bioanalysis, Universidad San Pablo-CEU, Madrid, Spain
4Department of Medicine and Medical Specialties, Alcalá University, Madrid, Spain
5Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Fundación Jiménez Díaz-Universidad Autónoma Madrid, Madrid, Spain
6University Hospital, Alcalá de Henares, Madrid, Spain
7Division of Nephrology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Department of Preventive Medicine and Public Health, University of Navarra, Pampona, Spain
9Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain
10Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
11Transgenics Unit, Spanish National Cancer Research Centre, Madrid, Spain
12Genomic Facility, Parque Científico de Madrid, Madrid, Spain
Find articles by Rodriguez-Puyol, D. in: JCI | PubMed | Google Scholar
1Program of Physiological and Pathological Processes, Centro de Biología Molecular “Severo Ochoa", Madrid, Spain
2Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain
3Centre for Metabolomics and Bioanalysis, Universidad San Pablo-CEU, Madrid, Spain
4Department of Medicine and Medical Specialties, Alcalá University, Madrid, Spain
5Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Fundación Jiménez Díaz-Universidad Autónoma Madrid, Madrid, Spain
6University Hospital, Alcalá de Henares, Madrid, Spain
7Division of Nephrology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Department of Preventive Medicine and Public Health, University of Navarra, Pampona, Spain
9Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain
10Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
11Transgenics Unit, Spanish National Cancer Research Centre, Madrid, Spain
12Genomic Facility, Parque Científico de Madrid, Madrid, Spain
Find articles by Marquez-Exposito, L. in: JCI | PubMed | Google Scholar
1Program of Physiological and Pathological Processes, Centro de Biología Molecular “Severo Ochoa", Madrid, Spain
2Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain
3Centre for Metabolomics and Bioanalysis, Universidad San Pablo-CEU, Madrid, Spain
4Department of Medicine and Medical Specialties, Alcalá University, Madrid, Spain
5Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Fundación Jiménez Díaz-Universidad Autónoma Madrid, Madrid, Spain
6University Hospital, Alcalá de Henares, Madrid, Spain
7Division of Nephrology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Department of Preventive Medicine and Public Health, University of Navarra, Pampona, Spain
9Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain
10Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
11Transgenics Unit, Spanish National Cancer Research Centre, Madrid, Spain
12Genomic Facility, Parque Científico de Madrid, Madrid, Spain
Find articles by Ruiz-Ortega, M. in: JCI | PubMed | Google Scholar
1Program of Physiological and Pathological Processes, Centro de Biología Molecular “Severo Ochoa", Madrid, Spain
2Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain
3Centre for Metabolomics and Bioanalysis, Universidad San Pablo-CEU, Madrid, Spain
4Department of Medicine and Medical Specialties, Alcalá University, Madrid, Spain
5Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Fundación Jiménez Díaz-Universidad Autónoma Madrid, Madrid, Spain
6University Hospital, Alcalá de Henares, Madrid, Spain
7Division of Nephrology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Department of Preventive Medicine and Public Health, University of Navarra, Pampona, Spain
9Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain
10Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
11Transgenics Unit, Spanish National Cancer Research Centre, Madrid, Spain
12Genomic Facility, Parque Científico de Madrid, Madrid, Spain
Find articles by Castillo, C. in: JCI | PubMed | Google Scholar
1Program of Physiological and Pathological Processes, Centro de Biología Molecular “Severo Ochoa", Madrid, Spain
2Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain
3Centre for Metabolomics and Bioanalysis, Universidad San Pablo-CEU, Madrid, Spain
4Department of Medicine and Medical Specialties, Alcalá University, Madrid, Spain
5Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Fundación Jiménez Díaz-Universidad Autónoma Madrid, Madrid, Spain
6University Hospital, Alcalá de Henares, Madrid, Spain
7Division of Nephrology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Department of Preventive Medicine and Public Health, University of Navarra, Pampona, Spain
9Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain
10Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
11Transgenics Unit, Spanish National Cancer Research Centre, Madrid, Spain
12Genomic Facility, Parque Científico de Madrid, Madrid, Spain
Find articles by
Sheng, X.
in:
JCI
|
PubMed
|
Google Scholar
|
1Program of Physiological and Pathological Processes, Centro de Biología Molecular “Severo Ochoa", Madrid, Spain
2Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain
3Centre for Metabolomics and Bioanalysis, Universidad San Pablo-CEU, Madrid, Spain
4Department of Medicine and Medical Specialties, Alcalá University, Madrid, Spain
5Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Fundación Jiménez Díaz-Universidad Autónoma Madrid, Madrid, Spain
6University Hospital, Alcalá de Henares, Madrid, Spain
7Division of Nephrology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Department of Preventive Medicine and Public Health, University of Navarra, Pampona, Spain
9Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain
10Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
11Transgenics Unit, Spanish National Cancer Research Centre, Madrid, Spain
12Genomic Facility, Parque Científico de Madrid, Madrid, Spain
Find articles by
Susztak, K.
in:
JCI
|
PubMed
|
Google Scholar
|
1Program of Physiological and Pathological Processes, Centro de Biología Molecular “Severo Ochoa", Madrid, Spain
2Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain
3Centre for Metabolomics and Bioanalysis, Universidad San Pablo-CEU, Madrid, Spain
4Department of Medicine and Medical Specialties, Alcalá University, Madrid, Spain
5Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Fundación Jiménez Díaz-Universidad Autónoma Madrid, Madrid, Spain
6University Hospital, Alcalá de Henares, Madrid, Spain
7Division of Nephrology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Department of Preventive Medicine and Public Health, University of Navarra, Pampona, Spain
9Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain
10Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
11Transgenics Unit, Spanish National Cancer Research Centre, Madrid, Spain
12Genomic Facility, Parque Científico de Madrid, Madrid, Spain
Find articles by
Ruiz-Canela, M.
in:
JCI
|
PubMed
|
Google Scholar
|
1Program of Physiological and Pathological Processes, Centro de Biología Molecular “Severo Ochoa", Madrid, Spain
2Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain
3Centre for Metabolomics and Bioanalysis, Universidad San Pablo-CEU, Madrid, Spain
4Department of Medicine and Medical Specialties, Alcalá University, Madrid, Spain
5Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Fundación Jiménez Díaz-Universidad Autónoma Madrid, Madrid, Spain
6University Hospital, Alcalá de Henares, Madrid, Spain
7Division of Nephrology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Department of Preventive Medicine and Public Health, University of Navarra, Pampona, Spain
9Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain
10Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
11Transgenics Unit, Spanish National Cancer Research Centre, Madrid, Spain
12Genomic Facility, Parque Científico de Madrid, Madrid, Spain
Find articles by
Salas-Salvado, J.
in:
JCI
|
PubMed
|
Google Scholar
|
1Program of Physiological and Pathological Processes, Centro de Biología Molecular “Severo Ochoa", Madrid, Spain
2Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain
3Centre for Metabolomics and Bioanalysis, Universidad San Pablo-CEU, Madrid, Spain
4Department of Medicine and Medical Specialties, Alcalá University, Madrid, Spain
5Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Fundación Jiménez Díaz-Universidad Autónoma Madrid, Madrid, Spain
6University Hospital, Alcalá de Henares, Madrid, Spain
7Division of Nephrology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Department of Preventive Medicine and Public Health, University of Navarra, Pampona, Spain
9Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain
10Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
11Transgenics Unit, Spanish National Cancer Research Centre, Madrid, Spain
12Genomic Facility, Parque Científico de Madrid, Madrid, Spain
Find articles by
Martinez-Gonzalez, M.
in:
JCI
|
PubMed
|
Google Scholar
|
1Program of Physiological and Pathological Processes, Centro de Biología Molecular “Severo Ochoa", Madrid, Spain
2Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain
3Centre for Metabolomics and Bioanalysis, Universidad San Pablo-CEU, Madrid, Spain
4Department of Medicine and Medical Specialties, Alcalá University, Madrid, Spain
5Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Fundación Jiménez Díaz-Universidad Autónoma Madrid, Madrid, Spain
6University Hospital, Alcalá de Henares, Madrid, Spain
7Division of Nephrology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Department of Preventive Medicine and Public Health, University of Navarra, Pampona, Spain
9Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain
10Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
11Transgenics Unit, Spanish National Cancer Research Centre, Madrid, Spain
12Genomic Facility, Parque Científico de Madrid, Madrid, Spain
Find articles by
Ortega, S.
in:
JCI
|
PubMed
|
Google Scholar
|
1Program of Physiological and Pathological Processes, Centro de Biología Molecular “Severo Ochoa", Madrid, Spain
2Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain
3Centre for Metabolomics and Bioanalysis, Universidad San Pablo-CEU, Madrid, Spain
4Department of Medicine and Medical Specialties, Alcalá University, Madrid, Spain
5Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Fundación Jiménez Díaz-Universidad Autónoma Madrid, Madrid, Spain
6University Hospital, Alcalá de Henares, Madrid, Spain
7Division of Nephrology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Department of Preventive Medicine and Public Health, University of Navarra, Pampona, Spain
9Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain
10Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
11Transgenics Unit, Spanish National Cancer Research Centre, Madrid, Spain
12Genomic Facility, Parque Científico de Madrid, Madrid, Spain
Find articles by Ramos-Ruiz, R. in: JCI | PubMed | Google Scholar
1Program of Physiological and Pathological Processes, Centro de Biología Molecular “Severo Ochoa", Madrid, Spain
2Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain
3Centre for Metabolomics and Bioanalysis, Universidad San Pablo-CEU, Madrid, Spain
4Department of Medicine and Medical Specialties, Alcalá University, Madrid, Spain
5Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Fundación Jiménez Díaz-Universidad Autónoma Madrid, Madrid, Spain
6University Hospital, Alcalá de Henares, Madrid, Spain
7Division of Nephrology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Department of Preventive Medicine and Public Health, University of Navarra, Pampona, Spain
9Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain
10Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
11Transgenics Unit, Spanish National Cancer Research Centre, Madrid, Spain
12Genomic Facility, Parque Científico de Madrid, Madrid, Spain
Find articles by
Lamas, S.
in:
JCI
|
PubMed
|
Google Scholar
|
Published January 19, 2021 - More info
Chronic kidney disease (CKD) remains a major epidemiological, clinical and biomedical challenge. During CKD, renal tubular epithelial cells (TECs) suffer a persistent inflammatory and profibrotic response. Fatty acid oxidation (FAO), the main source of energy for TECs, is reduced in kidney fibrosis and contributes to its pathogenesis. To determine if FAO gain-of-function (FAO-GOF) could protect from fibrosis, we generated a conditional transgenic mouse model with overexpression of the fatty acid shuttling enzyme carnitine palmitoyl-transferase 1 A (CPT1A) in TECs. Cpt1a knock-in mice subjected to three different models of renal fibrosis (unilateral ureteral obstruction, folic acid nephropathy-FAN and adenine induced nephrotoxicity) exhibited decreased expression of fibrotic markers, a blunted pro-inflammatory response and reduced epithelial cell damage and macrophage influx. Protection from fibrosis was also observed when Cpt1a overexpression was induced after FAN. FAO-GOF restituted oxidative metabolism and mitochondrial number and enhanced bioenergetics increasing palmitate oxidation and ATP levels, changes also recapitulated in TECs exposed to profibrotic stimuli. Studies in patients evidenced decreased CPT1 levels and increased accumulation of short and middle chain acyl-carnitines, reflecting impaired FAO in human CKD. We propose that strategies based on FAO-GOF may constitute powerful alternatives to combat fibrosis inherent to CKD.