In this video collection, authors of findings published in The Journal of Clinical Investigation present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Author's Take Guidelines page.
In this episode, Peter van der Meer and Mathilde Vermeer explain the pathological role of KLHL24 methionine start-codon mutations in the development of dilated cardiomyopathy using hiPSC-derived dynamically loaded engineered heart tissues.
In this episode, Catherine Ong explains that adjunctive doxycycline with standard anti-TB treatment suppresses pathological MMPs in pulmonary tuberculosis patients.
In this episode, Ceng Luo and Zhen-Zhen Li explain that extracellular matrix laminin β1 protects against neuropathic pain and related anxiodepression through integrin β1-dependent actin reorganization.
In this episode, the authors explain that in multisystem inflammatory syndrome in children (MIS-C), increased gastrointestinal mucosal permeability allows SARS-CoV-2 antigens in the GI tract to leak into the bloodstream, triggering cytokine storm and hyperinflammatory responses.
In this episode, Valder Arruda explains that depletion of the cytokine B cell activating factor in hemophilia A may provide a way to prevent or eradicate factor VIII inhibitors.