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Clinical Medicine
Scientific Show Stopper
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Accelerated aging
Aging is a complex physiological process that is governed by multiple genetic, epigenetic, and environmental factors. Many different cellular signaling pathways have been reported to regulate...
Published March 15, 2013
Scientific Show Stopper
What lies beneath
Mycobacterium ulcerans infects the skin and subcutaneous tissues. It secretes a lipid toxin, mycolactone, which causes open skin lesions, known as Buruli ulcers. Laure Guenin-Macé and...
Published March 15, 2013
Scientific Show Stopper
Sorting out fertility after childhood cancer
As success rates in treating childhood cancers have improved, greater emphasis is now being placed on quality of life issues following successful treatment. Many cancer treatments can lead to...
Published March 15, 2013
Scientific Show Stopper
Zymogenesis
Gastric zymogenic cells release enzyme precursors (zymogens) into the stomach to assist in the digestion of food. As the lining of the stomach is constantly being renewed, it is necessary to...
Published March 8, 2013
Scientific Show Stopper
Fully wired
The enteric nervous system (ENS), the “little brain” that resides within the gut wall, governs motility, secretion, and blood flow in the human gastrointestinal tract. Failure of the ENS to...
Published March 8, 2013
Scientific Show Stopper
Flipping the switch on angiogenesis
The angiogenic switch, in which tumors begin recruiting blood vessels to amplify blood supply, is an important step in tumor progression, but the molecular mechanisms that initiate this step...
Published March 1, 2013
Scientific Show Stopper
A nanogel-based therapy for lupus
Systemic lupus erythematosus (SLE) is disease in which the immune system mistakenly attacks healthy tissues, resulting in inflammation and tissue damage. Current treatments are focused on...
Published March 1, 2013
Scientific Show Stopper
Branching out
Myocardial hypertrophy, a thickening of the heart muscle, is an adaptation that occurs with increased stress on the heart, such as high blood pressure. As the heart muscle expands, it...
Published March 1, 2013
Scientific Show Stopper
Brain "clean-up crew" visualized by MRI
All parts of the body generate waste that must be flushed out in order to remove harmful materials, old proteins, and other cellular detritus. Most tissues utilize the lymphatic system to keep...
Published February 22, 2013
Scientific Show Stopper
Pulmonary fibrosis: between a ROCK and a hard place
Pulmonary fibrosis is a scarring or thickening of the lungs that causes shortness of breath, a dry cough, fatigue, chest discomfort, weight loss, a decrease in the ability of the lungs to...
Published February 22, 2013
Scientific Show Stopper
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