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Clinical Medicine
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174 Posts
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Battling cholangiocarcinoma with WNT inhibition
Cholangiocarcinoma is a cancer of the bile duct that has a poor prognosis, largely due to it being refractory to available therapies. In this episode, Stuart Forbes and Luke Bolter reveal that the canonical WNT signaling pathway drives cholangiocarc...
Published February 17, 2015
Author's Take
Insight into T cell-mediated neuroprotection
Injury to the central nervous system (CNS) results in a cascade of events that leads to cell death and neurodegeneration. Recent studies have shown that T cells infiltrate sites of neuronal injury and are protective against damage, though it is not ...
Published January 20, 2015
Author's Take
Vascular adhesion protein-1 and liver disease progression
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder and is associated with metabolic dysfunction. Persistent hepatic inflammation in diseased livers results in progressive fibrosis and loss of hepatic function. Vascular adhesi...
Published December 22, 2014
Author's Take
Linking dietary sphingolipids to inflammation and intestinal carcinogenesis
Many lines of evidence support a link between prolonged inflammation and tumorigenic transformation. For example, patients with inflammatory bowel disease are at increased risk of developing colon cancer. In this episode, Julie Saba, Emilie Degagn&e...
Published November 26, 2014
Author's Take
A murine model of JC virus infection
The rare demyelinating disorder progressive multifocal leukoencephalopathy is triggered by JC virus infection of glial cells. Current models to study JC virus infection are limited to cell culture systems due to the human-selective nature of t...
Published November 17, 2014
Author's Take
Targeting estrogen receptors to prevent binge eating
Binge eating is associated with obesity and depression. This disorder is more prevalent in women, and there is an apparent correlation between low estrogen levels and this behavior. In this episode, Yong Xu, Xuehong Cao, and Pingwen Xu demonstrate t...
Published October 1, 2014
Author's Take
Examining the role of cullin 3 in hyperkalemic hypertension
Familial hyperkalemic hypertension (FHHt) is a rare monogenic disease that results from mutations in the kinases WNK1 and WNK4 or mutations in the ubiquitin ligase cullin 3 (CUL3) or the CUL3 substrate adaptor kelch-like 3...
Published September 29, 2014
Author's Take
Identification of weight loss-mediating liraglutide targets
The type 2 diabetes drug liraglutide is a glucagon-like peptide-1 receptor (GLP-1R) agonist that lowers blood glucose and reduces body weight. Liraglutide is being investigated for clinical use as a treatment for obesity; however, the mechanism of a...
Published September 9, 2014
Author's Take
Examining plasma fibronectin in hemostasis
Platelet accumulation and coagulation are key processes required to stop bleeding following blood vessel injury. Plasma fibronectin, which circulates freely in the blood, contains collagen, fibrin, and integrin binding sites and is well poised...
Published September 2, 2014
Author's Take
Insulin secretory granule replenishment requires SORCS1
There is a strong association between obesity and type 2 diabetes (T2D); however, the majority of obese individuals do not develop T2D, supporting that genetic predisposition is an important component of the disease. Alan Attie and colleagues previo...
Published August 26, 2014
Author's Take
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