Review Series

Prostaglandins and their precursors

Series edited by Patrick Loll and Garret A. Fitzgerald

The cyclooxygenases COX-1 and COX-2 catalyze the conversion of arachidonic acid to biologically active prostaglandins, which have numerous physiological functions. The series discusses the current status and future promise of prostaglandin research.

Articles in series

Series Introduction: COX in a crystal ball: current status and future promise of prostaglandin research
Garret A. FitzGerald, Patrick Loll
Garret A. FitzGerald, Patrick Loll
Published June 1, 2001
Citation Information: J Clin Invest. 2001;107(11):1335-1338. https://doi.org/10.1172/JCI13037.
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Arachidonic acid as a bioactive molecule
Alan R. Brash
Alan R. Brash
Published June 1, 2001
Citation Information: J Clin Invest. 2001;107(11):1339-1345. https://doi.org/10.1172/JCI13210.
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Arachidonic acid as a bioactive molecule

Abstract

Authors

Alan R. Brash

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Regulated formation of eicosanoids
F.A. Fitzpatrick, Roy Soberman
F.A. Fitzpatrick, Roy Soberman
Published June 1, 2001
Citation Information: J Clin Invest. 2001;107(11):1347-1351. https://doi.org/10.1172/JCI13241.
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Regulated formation of eicosanoids

Abstract

Authors

F.A. Fitzpatrick, Roy Soberman

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Unorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathways
Charles N. Serhan, Ernst Oliw
Charles N. Serhan, Ernst Oliw
Published June 15, 2001
Citation Information: J Clin Invest. 2001;107(12):1481-1489. https://doi.org/10.1172/JCI13375.
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Why there are two cyclooxygenase isozymes
William L. Smith, Robert Langenbach
William L. Smith, Robert Langenbach
Published June 15, 2001
Citation Information: J Clin Invest. 2001;107(12):1491-1495. https://doi.org/10.1172/JCI13271.
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Why there are two cyclooxygenase isozymes

Abstract

Authors

William L. Smith, Robert Langenbach

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Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes
Stephen L. Tilley, … , Thomas M. Coffman, Beverly H. Koller
Stephen L. Tilley, … , Thomas M. Coffman, Beverly H. Koller
Published July 1, 2001
Citation Information: J Clin Invest. 2001;108(1):15-23. https://doi.org/10.1172/JCI13416.
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Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes

Abstract

Authors

Stephen L. Tilley, Thomas M. Coffman, Beverly H. Koller

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Genetic and pharmacological analysis of prostanoid receptor function
Shuh Narumiya, Garret A. FitzGerald
Shuh Narumiya, Garret A. FitzGerald
Published July 1, 2001
Citation Information: J Clin Invest. 2001;108(1):25-30. https://doi.org/10.1172/JCI13455.
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Genetic and pharmacological analysis of prostanoid receptor function

Abstract

Authors

Shuh Narumiya, Garret A. FitzGerald

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Cyclooxygenase-selective inhibition of prostanoid formation: transducing biochemical selectivity into clinical read-outs
Carlo Patrono, … , Paola Patrignani, Luis A. García Rodríguez
Carlo Patrono, … , Paola Patrignani, Luis A. García Rodríguez
Published July 1, 2001
Citation Information: J Clin Invest. 2001;108(1):7-13. https://doi.org/10.1172/JCI13418.
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