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Unorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathways
Charles N. Serhan, Ernst Oliw
Charles N. Serhan, Ernst Oliw
Published June 15, 2001
Citation Information: J Clin Invest. 2001;107(12):1481-1489. https://doi.org/10.1172/JCI13375.
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Unorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathways

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Abstract

Authors

Charles N. Serhan, Ernst Oliw

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Figure 1

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Cyclooxygenase reactions and products: prostaglandins and the impact of ...
Cyclooxygenase reactions and products: prostaglandins and the impact of aspirin. Conversion of arachidonic acid to bioactive products involves stereoselective insertion of oxygen governed by COX (see text for details). Aspirin blocks formation of PGs from COX-1 and -2. In addition, with COX-2, aspirin triggers the formation of bioactive aspirin-triggered lipid mediators.

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