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A neuron under attack
Cultured hippocampal neurons are stained for phosphorylated IRS-1 (red) and Aβ oligomers (AβOs, blue). AβOs are diffusible synaptotoxins that accumulate in the brains of Alzheimer disease (AD)...
Published March 26, 2012
Scientific Show Stopper
Visualizing cyclin D1-driven chromosomal instability
Confocal maximum Z projections of MEFs in metaphase, immunostained for α-tubulin (violet), γ- tubulin (yellow) and DAPI (blue). Casimiro et al. show that in contrast to Cyclin D1-/- cells...
Published February 7, 2012
Scientific Show Stopper
Human tumor inspires mouse model
Dr. Tomoaki Kato, of Columbia University, removed an abdominal myxoid round cell liposarcoma (MRCLS) from a patient described in Charytonowicz et al. The tumor had 4 segments, the largest...
Published February 1, 2012
Scientific Show Stopper
Reticulon 2B helps the ER shape up
HeLa cell expressing Myc-tagged mutant Spastin (green) and Reticulon 2B (red). Montenegro and colleagues demonstrate that mutations in the endoplasmic reticulum-shaping protein Reticulon 2...
Published January 9, 2012
Scientific Show Stopper
Nurturing stem cells to promote regeneration after lung injury
Airways from napthalene injured mouse lung. Volckaert and colleagues provide a conceptual framework for injury-induced epithelial regeneration in the lung by parabronchial smooth muscle cells.
Published October 10, 2011
Scientific Show Stopper
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