The pulmonary disease tuberculosis (TB) is a global health problem that results from Mycobacterium tuberculosis (Mtb) infection. As parasitic helminth worms are endemic to areas with high rates of TB, helminths are thought to enhance susceptibility to Mtb. In this episode, Shabaana Khader and colleagues demonstrate that helminth coinfection exacerbates TB by promoting formation of arginase-1-expressing inflammatory granulomas, resulting in increased lung damage. Moreover, inflammatory phenotypes associated with coinfection were reversed in a murine co-infection model by treatment with anti-helminthic agents. This study provides mechanistic insight into the link between helminth coinfection and TB disease severity.
Parasitic helminth worms, such as
Leticia Monin, Kristin L. Griffiths, Wing Y. Lam, Radha Gopal, Dongwan D. Kang, Mushtaq Ahmed, Anuradha Rajamanickam, Alfredo Cruz-Lagunas, Joaquín Zúñiga, Subash Babu, Jay K. Kolls, Makedonka Mitreva, Bruce A. Rosa, Rosalio Ramos-Payan, Thomas E. Morrison, Peter J. Murray, Javier Rangel-Moreno, Edward J. Pearce, Shabaana A. Khader