RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models
Nadine Haase, Donald J. Foster, Mark W. Cunningham, Julia Bercher, Tuyen Nguyen, Svetlana Shulga-Morskaya, Stuart Milstein, Sarfraz Shaikh, Jeff Rollins, Michaela Golic, Florian Herse, Kristin Kräker, Ivo Bendix, Meray Serdar, Hanna Napieczynska, Arnd Heuser, Alexandra Gellhaus, Kristin Thiele, Gerd Wallukat, Dominik N. Müller, Babbette LaMarca, Ralf Dechend
Nadine Haase, Donald J. Foster, Mark W. Cunningham, Julia Bercher, Tuyen Nguyen, Svetlana Shulga-Morskaya, Stuart Milstein, Sarfraz Shaikh, Jeff Rollins, Michaela Golic, Florian Herse, Kristin Kräker, Ivo Bendix, Meray Serdar, Hanna Napieczynska, Arnd Heuser, Alexandra Gellhaus, Kristin Thiele, Gerd Wallukat, Dominik N. Müller, Babbette LaMarca, Ralf Dechend
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Research Article Reproductive biology

RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models

Abstract

Authors

Nadine Haase, Donald J. Foster, Mark W. Cunningham, Julia Bercher, Tuyen Nguyen, Svetlana Shulga-Morskaya, Stuart Milstein, Sarfraz Shaikh, Jeff Rollins, Michaela Golic, Florian Herse, Kristin Kräker, Ivo Bendix, Meray Serdar, Hanna Napieczynska, Arnd Heuser, Alexandra Gellhaus, Kristin Thiele, Gerd Wallukat, Dominik N. Müller, Babbette LaMarca, Ralf Dechend

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Figure 10

rAgt siRNA has no negative impact on calvarial and renal morphology of the fetus.

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rAgt siRNA has no negative impact on calvarial and renal morphology of ...
(A) Measurement of fetal skull width showed no difference in pups from untreated and siRNA-treated NP rats (n = 6 each; mean ± SEM). (B) Fetal skull length was also unchanged in pups from untreated and siRNA-treated NP rats (n = 6 each; mean ± SEM). (C) Representative micro-CT images of fetal rat skulls. (D) The kidney weight/body weight ratio of 3-week-old offspring was not changed between untreated and siRNA-treated groups (n = 10 each; mean ± SEM). (E) Number of glomeruli in 3-week-old offspring kidneys was not influenced by siRNA treatment (n = 10 each; mean ± SEM). (F) Representative images of Masson’s trichome–stained kidney sections of offspring from untreated and siRNA-treated NP rats. (G) Representative images of H&E-stained kidney sections of offspring from untreated and siRNA-treated NP rats.