Senescent cells and osteoarthritis: a painful connection
Ok Hee Jeon,1,2 Nathaniel David,3 Judith Campisi,2 and Jennifer H. Elisseeff1
1Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
2Buck Institute for Research on Aging, Novato, California, USA.
3Unity Biotechnology, Brisbane, California, USA.
Address correspondence to: Jennifer H. Elisseeff, Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Smith Building, Room 5035, 400 N. Broadway, Baltimore, Maryland 21231, USA. Phone: 410.614.6837; Email: jhe@jhu.edu.
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1Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
2Buck Institute for Research on Aging, Novato, California, USA.
3Unity Biotechnology, Brisbane, California, USA.
Address correspondence to: Jennifer H. Elisseeff, Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Smith Building, Room 5035, 400 N. Broadway, Baltimore, Maryland 21231, USA. Phone: 410.614.6837; Email: jhe@jhu.edu.
Find articles by David, N. in: JCI | PubMed | Google Scholar
1Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
2Buck Institute for Research on Aging, Novato, California, USA.
3Unity Biotechnology, Brisbane, California, USA.
Address correspondence to: Jennifer H. Elisseeff, Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Smith Building, Room 5035, 400 N. Broadway, Baltimore, Maryland 21231, USA. Phone: 410.614.6837; Email: jhe@jhu.edu.
Find articles by Campisi, J. in: JCI | PubMed | Google Scholar
1Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
2Buck Institute for Research on Aging, Novato, California, USA.
3Unity Biotechnology, Brisbane, California, USA.
Address correspondence to: Jennifer H. Elisseeff, Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Smith Building, Room 5035, 400 N. Broadway, Baltimore, Maryland 21231, USA. Phone: 410.614.6837; Email: jhe@jhu.edu.
Find articles by Elisseeff, J. in: JCI | PubMed | Google Scholar
First published April 2, 2018 - More info
J Clin Invest. 2018;128(4):1229–1237. https://doi.org/10.1172/JCI95147.
Copyright © 2018, American Society for Clinical Investigation
Senescent cells (SnCs) are associated with age-related pathologies. Osteoarthritis is a chronic disease characterized by pain, loss of cartilage, and joint inflammation, and its incidence increases with age. For years, the presence of SnCs in cartilage isolated from patients undergoing total knee artificial implants has been noted, but these cells’ relevance to disease was unclear. In this Review, we summarize current knowledge of SnCs in the multiple tissues that constitute the articular joint. New evidence for the causative role of SnCs in the development of posttraumatic and age-related arthritis is reviewed along with the therapeutic benefit of SnC clearance. As part of their senescence-associated secretory phenotype, SnCs secrete cytokines that impact the immune system and its response to joint tissue trauma. We present concepts of the immune response to tissue trauma as well as the interactions with SnCs and the local tissue environment. Finally, we discuss therapeutic implications of targeting SnCs in treating osteoarthritis.
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