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T cells take directions from supporting cast in graft-versus-host disease
Derk Amsen
Derk Amsen
Published March 20, 2017
Citation Information: J Clin Invest. 2017;127(4):1215-1217. https://doi.org/10.1172/JCI93552.
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Commentary

T cells take directions from supporting cast in graft-versus-host disease

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Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) remains the only treatment option for several severe hematological malignancies. The development of graft-versus-host disease (GVHD) is a common complication of the procedure and results when donor T cells become activated against recipient-specific antigens. The factors that drive the alloreactive T cell response are not completely understood. In this issue of the JCI, Chung and colleagues present evidence that stromal cells within lymphoid tissue express the Notch ligands Delta-like 1/4 (DLL1 and DLL4), which in turn directly activate T cells. Importantly, inhibition of DLL1/DLL4-mediated Notch signaling in murine HSCT models dramatically reduced GVHD and improved graft survival.

Authors

Derk Amsen

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