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- Corrigendum (November 2016)
Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency
Jolan E. Walter,1,2 Lindsey B. Rosen,3 Krisztian Csomos,1 Jacob M. Rosenberg,4 Divij Mathew,5 Marton Keszei,6 Boglarka Ujhazi,1,7 Karin Chen,8 Yu Nee Lee,2 Irit Tirosh,9 Kerry Dobbs,2 Waleed Al-Herz,10 Morton J. Cowan,11 Jennifer Puck,11 Jack J. Bleesing,12 Michael S. Grimley,12 Harry Malech,13 Suk See De Ravin,13 Andrew R. Gennery,14 Roshini S. Abraham,15 Avni Y. Joshi,16 Thomas G. Boyce,17 Manish J. Butte,18 Kari C. Nadeau,18 Imelda Balboni,18 Kathleen E. Sullivan,19 Javeed Akhter,20 Mehdi Adeli,21 Reem A. El-Feky,22 Dalia H. El-Ghoneimy,22 Ghassan Dbaibo,23 Rima Wakim,23 Chiara Azzari,24 Paolo Palma,25 Caterina Cancrini,25 Kelly Capuder,2 Antonio Condino-Neto,26 Beatriz T. Costa-Carvalho,27 Joao Bosco Oliveira,28 Chaim Roifman,29 David Buchbinder,30 Attila Kumanovics,31 Jose Luis Franco,32 Tim Niehues,33 Catharina Schuetz,34 Taco Kuijpers,35 Christina Yee,2 Janet Chou,2 Michel J. Masaad,2 Raif Geha,2 Gulbu Uzel,3 Rebecca Gelman,36 Steven M. Holland,3 Mike Recher,37 Paul J. Utz,4,38 Sarah K. Browne,3 and Luigi D. Notarangelo2,39
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Walter, J. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Rosen, L. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Csomos, K. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Rosenberg, J. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Mathew, D. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Keszei, M. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Ujhazi, B. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Chen, K. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Lee, Y. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Tirosh, I. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Dobbs, K. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Al-Herz, W. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Cowan, M. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Puck, J. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Bleesing, J. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Grimley, M. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Malech, H. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by De Ravin, S. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Gennery, A. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Abraham, R. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Joshi, A. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Boyce, T. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Butte, M. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Nadeau, K. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Balboni, I. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Sullivan, K. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Akhter, J. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Adeli, M. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by El-Feky, R. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by El-Ghoneimy, D. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Dbaibo, G. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Wakim, R. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Azzari, C. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Palma, P. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Cancrini, C. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Capuder, K. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Condino-Neto, A. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Costa-Carvalho, B. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Oliveira, J. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Roifman, C. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Buchbinder, D. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Kumanovics, A. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Franco, J. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Niehues, T. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Schuetz, C. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Kuijpers, T. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Yee, C. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Chou, J. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Masaad, M. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Geha, R. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Uzel, G. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Gelman, R. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Holland, S. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
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1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
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1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Browne, S. in: JCI | PubMed | Google Scholar
1Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
3Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
4Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA.
5Integrated Department of Immunology, University of Colorado at Denver, Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA.
6Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
7Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
8Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
9Pediatric Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
10Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
11Pediatric Allergy, Immunology and Blood and Marrow Transplant Division, UCSF Benioff Children’s Hospital, San Francisco, California, USA.
12Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
13Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland, USA.
14Department of Pediatric Immunology and Institute of Cellular Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom.
15Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
16Division of Pediatric Allergy/Immunology, Department of Pediatric and Adolescent Medicine, and
17Division of Pediatric Infectious Diseases, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
18Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, Stanford University, Stanford, California, USA.
19Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
20Jeffrey Modell Foundation Immunology Referral Center, Advocate Children’s Hospital, Oak Lawn, Illinois, USA.
21Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
22Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
23Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
24Anna Meyer Children’s University Hospital, Florence, Italy.
25University Department of Paediatrics, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.
26Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
27Federal University of São Paulo, São Paulo, Brazil.
28Instituto de Medicina Integral, Recife, Brazil.
29Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
30Pediatric Hematology, CHOC Children’s Hospital - UC Irvine, Orange, California, USA.
31Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
32Group of Primary Immunodeficiencies, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
33Centre for Child Health and Adolescence, Helios Klinikum Krefeld Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
34Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany.
35Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands.
36Dana Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, Massachusetts, USA.
37Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland.
38Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA.
39Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA.
Address correspondence to: Luigi D. Notarangelo, Division of Immunology, Boston Children’s Hospital, Karp Research Building, Room 10217, One Blackfan Circle, 10th floor, Room 10217, Boston, Massachusetts 02115, USA. Phone: 617.919.2277; E-mail: Luigi.Notarangelo@childrens.harvard.edu. Or to: Jolan E. Walter, Division of Allergy Immunology, Massachusetts General Hospital for Children, 275 Cambridge Street, Suite 530, Boston, Massachusetts 02114, USA. Phone: 617.726.8707; E-mail: jewalter@mgh.harvard.edu.
Authorship note: Jolan E. Walter and Lindsey B. Rosen are co–first authors. Mike Recher and Paul J. Utz contributed equally to this work.
Find articles by Notarangelo, L. in: JCI | PubMed | Google Scholar
Published October 12, 2015 - More info
J Clin Invest. 2015;125(11):4135–4148. https://doi.org/10.1172/JCI80477.
Copyright © 2015, American Society for Clinical Investigation
Received: December 12, 2014; Accepted: September 3, 2015
Related article:
Abstract
Authors
Jolan E. Walter, Lindsey B. Rosen, Krisztian Csomos, Jacob M. Rosenberg, Divij Mathew, Marton Keszei, Boglarka Ujhazi, Karin Chen, Yu Nee Lee, Irit Tirosh, Kerry Dobbs, Waleed Al-Herz, Morton J. Cowan, Jennifer Puck, Jack J. Bleesing, Michael S. Grimley, Harry Malech, Suk See De Ravin, Andrew R. Gennery, Roshini S. Abraham, Avni Y. Joshi, Thomas G. Boyce, Manish J. Butte, Kari C. Nadeau, Imelda Balboni, Kathleen E. Sullivan, Javeed Akhter, Mehdi Adeli, Reem A. El-Feky, Dalia H. El-Ghoneimy, Ghassan Dbaibo, Rima Wakim, Chiara Azzari, Paolo Palma, Caterina Cancrini, Kelly Capuder, Antonio Condino-Neto, Beatriz T. Costa-Carvalho, Joao Bosco Oliveira, Chaim Roifman, David Buchbinder, Attila Kumanovics, Jose Luis Franco, Tim Niehues, Catharina Schuetz, Taco Kuijpers, Christina Yee, Janet Chou, Michel J. Masaad, Raif Geha, Gulbu Uzel, Rebecca Gelman, Steven M. Holland, Mike Recher, Paul J. Utz, Sarah K. Browne, Luigi D. Notarangelo
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Results
Characteristics of RAG-deficient patients. We have studied 30 patients with RAG deficiency, including 13 patients with CID-G/AI; 5 with LS; 7 with OS; 4 with SCID; and 1 with TCL. The clinical, immunological, and molecular features of these patients are reported in Supplemental Table 1; supplemental material available online with this article; doi:10.1172/JCI80477DS1.
Among the 13 patients with CID-G/AI (age range: 1–30 years; median: 10 years), the majority (11 of 13, 85%) were females. All had a history of infections, including severe varicella infection, leading to significant complications (periorbital cellulitis, hepatitis, encephalitis, or disseminated disease) in 6 patients (CID patients 2, 3, 4, 6, 9, and 13) (46%). One patient (CID-5) developed EBV-associated tonsillar lymphoma. Ten of the thirteen patients (77%) with CID-G/AI had a history of cytopenias and/or other autoimmune manifestations (vitiligo, myasthenia gravis, vasculitis, psoriasis). Furthermore, 7 of 13 CID-G/AI patients (54%) had granulomas affecting various organs: skin, tongue, adenoids, spleen, lungs, and the perineal area. Most of the CID-G/AI patients (10 of 13, 77%) received replacement therapy with i.v. Igs (IVIGs). Eight patients (61.5%) received hematopoietic cell transplantation (HCT) at ages ranging from 1.5 to 19 years. Five CID-G/AI patients (38.5%) died at 5, 9, 10, 20, and 27 years of age, respectively. The causes of death included central line Candida sepsis (patient CID-8) (9); sepsis (patient CID-11); fatal Aspergillus pneumonia (patient CID-17) (17); graft-versus-host disease (GVHD) (patient CID-4); and accident after successful HCT (patient CID-1) (10). Two patients (CID-9 and -14) remain clinically stable on IVIGs and immune modulation at 30 and 17 years of age, respectively.
Among the 5 patients with LS (age range: 3 months to 18 years; median: 2 years), 4 had a history of autoimmunity, including cytopenias, alopecia, vitiligo, psoriasis, and Crohn disease (Supplemental Table 1). All 5 had a history of infections. In particular, 3 patients experienced chronic or severe CMV or adenovirus infection that, in 2 of these patients (LS-5 and LS-6), was associated with expansion of TCRγδ+ T cells. All patients required IVIGs, and 4 (80%) received HCT.
Among the 7 patients with OS (age range: 3 weeks to 28 months; median: 4 months), 4 had a history of severe or recurrent bacterial, viral, or fungal infections (Supplemental Table 1). One patient (OS-11) experienced disseminated adenovirus infection. One patient (OS-10) developed autoimmune hemolytic anemia (AIHA). All OS patients received HCT at ages ranging from 2 to 21 months; 5 of these patients are alive, and 2 patients (OS-2 and OS-10) died from GVHD.
Four patients had SCID, and 1 of these patients (SCID-5) had OS-like manifestations due to maternal T lymphocyte engraftment. Two of these patients presented with severe infections due to respiratory syncytial virus (RSV) and Pneumocystis jiroveci, respectively. All SCID patients received HCT between 2 weeks and 4 months of age. Three are alive, whereas 1 patient (SCID-5) died of veno-occlusive disease (VOD) secondary to busulfan toxicity (Supplemental Table 1),
The characteristics of each group of patients are summarized in Table 1. Functional analysis of the mutated RAG proteins showed that patients with CID-G/AI carried mutations that allowed higher levels of residual recombination activity than did those identified in patients with LS, OS, or SCID (Supplemental Table 1), confirming our recent observations (18).
Identification of multiple autoantibodies in RAG-deficient patients with PID. In an attempt to characterize autoantibody profiles in patients with RAG deficiency and to identify the most common autoantigens, we probed microarrays (generated by the Genomic and Microarray Core Facility at the University of Texas Southwestern Medical Center) containing a series of autoantigens involved in connective tissue diseases (Supplemental Table 2) with plasma from 22 patients with RAG deficiency (CID-G/AI, n = 8; TCL, n = 1; OS, n = 7; LS, n = 2; SCID, n = 4) (Table 1 and Supplemental Table 1). All patients were tested for the presence of autoantibodies of the IgG isotype, and all but 1 (CID-9) were tested for autoantibodies of the IgM isotype. Fifteen of the twenty-two patients (68%) were on Ig replacement therapy when the sample was obtained.
In each case, individual microarrays were also probed with sera from healthy donors as negative controls (n = 19 and n = 16 for IgG and IgM autoantibodies, respectively) and from a patient with systemic lupus erythematosus (SLE), who lacked RAG mutations, as a positive control. Both IgG and IgM autoantibodies were detected with increased frequency in patients with OS and in those with CID-G/AI (Supplemental Figures 1 and 2, respectively). We defined a group of RAG-deficient patients as “multireactive” when their plasma contained IgG autoantibodies against at least approximately 20% (13 of 66) of the self-antigens represented on the array. The relative frequency of multireactive samples was higher in RAG-deficient patients than in healthy controls (P = 0.0000008) and was especially high in patients with a milder phenotype (CID-G/AI and TCL) compared with samples in patients with a more severe presentation (SCID/LS/OS) (P = 0.028) (Figure 1A). However, multireactive autoantibodies were also detected in 1 patient with OS (OS-5) and in the single patient with SCID and maternal engraftment (SCID-5). We identified 21 common autoantigens, defined as specific targets for IgG autoantibodies that were present in at least 20% of the patients studied (Supplemental Figure 3). Among these, 11 autoantigens were detected at significantly higher levels in multireactive patients belonging to the CID-G/AI subgroup as compared with the levels detected in healthy controls (P < 0.05) (Supplemental Table 3). These autoantibodies included some that are characteristic of various autoimmune diseases such as SLE, rheumatoid arthritis, and Sjögren’s syndrome (Ro/SSA-52Kda, U1-snRNP-BB’, proteoglycan, alanyl-tRNA synthetase), and celiac disease (tissue transglutaminase [tTG]) (Figure 1B).
Figure 1Autoantibodies in RAG-deficient patients as detected by protein microarray. (A) IgG autoantibodies in 19 healthy controls (HCs) and 22 patients with RAG mutations. RAG-deficient patients were divided into 2 groups according to the severity of the clinical phenotype. Group 1 included patients with T–B– SCID, OS, and LS. Group 2 included patients with delayed presentation and/or a milder phenotype: CID-G/AI and TCL. MFI was normalized to that of healthy controls (mean + 2 SDs = 1), generating the RAR. Healthy controls had a lower percentage of positivity than did patients with RAG mutations (P = 0.0000008), and group 1 had a lower percentage of positivity than did group 2 (P = 0.028) as determined by Wilcoxon test with Holm’s adjustment. Samples that reacted to at least 20% of the self-antigens were defined as multireactive. (B) RAR to 11 autoantigens for which significantly higher levels of autoantibodies were found in the plasma of 5 CID-G/AI patients as compared with levels in 19 healthy controls. *P < 0.0005, **P < 0.0001, and ***P < 0.0001 by Wilcoxon test with Holm’s adjustment. Empty boxes indicate the range of RAR in healthy controls, with the bar representing the mean value. Hemo, hemocyanin; MPO, myeloperoxidase; PCNA, proliferating cell nuclear antigen; PL-12, alanyl-tRNA synthetase; PG, proteoglycan; RPLP, ribosomal phosphoprotein 0; Ro/SSA, ribonucleoprotein/Sjögren’s syndrome antigen A, 52 kDa; Tg, thyroglobulin; U1-BB’, U1 small nuclear ribonucleoprotein BB’ 9; U1-C, U1 small nuclear ribonucleoprotein C.
Distinctive anti-cytokine autoantibody signature in patients with RAG-dependent immunodeficiencies. Anti-cytokine antibodies have been detected in various PIDs and may contribute to disease phenotypes when capable of neutralizing cytokine biological activity (19, 20). We have previously reported on the presence of anti–IFN-α autoantibodies in 2 siblings with RAG deficiency who presented with autoimmunity and immunodeficiency (21). However, the frequency, specificity, and biological activity of anti-cytokine antibodies in patients with RAG mutations and various clinical phenotypes have not been described. To address this issue, we probed an extended protein microarray (generated in Dr. Utz’s laboratory at Stanford University) containing purified cytokines and chemokines (n = 63) as well as conventional autoantigens (n = 93) (Supplemental Table 4) with plasma from 16 healthy controls and 14 RAG-deficient patients (CID-G/AI, n = 8; TCL, n = 1; OS, n = 3; LS, n = 2) (Table 1). A distinct panel of autoantibodies (cluster 2) emerged that targeted IFN-α, IFN-ω, and IL-12, mainly in the CID-G/AI, TCL, and LS subgroups (Figure 2A and Supplemental Figure 4). Significance analysis of microarrays (SAM) identified significant differences in the presence of antibodies against IFN-α and thyroperoxidase (TPO) in the RAG-dependent PIDs compared with that seen in controls (Figure 2B).
Figure 2Anti-cytokine antibodies in RAG-deficient patients. (A) Heatmap of autoantibody reactivity. Plasma samples from 16 healthy controls (Ctr), 14 RAG-deficient patients (OS, n = 3; LS, n = 2; CID-G/AI, n = 8; idiopathic CD4+ TCL, n = 1), and 1 patient with APS-1 were tested for anti-cytokine antibodies. The complete array is shown in the left panel, and the area with the highest reactivity is magnified on the right. Antibodies against IFN-α, IFN-ω, and IL-12 (in red) were detected with high MFI in cluster 2, including RAG-deficient patients and APS-1 patients as a positive control. (B) Elevated levels of antibodies against TPO and IFN-α were detected in RAG-deficient patients as compared with healthy controls using SAM after 10,000 permutations of the data with an FDR of less than 0.00001. (C) Multiplex bead assay for anti-cytokine antibodies. Levels of antibodies targeting IFN-α, IFN-ω, IL-12p70, IFN-γ, IFN-β, TNF-α, and IL-22 in healthy controls (n = 15) and RAG-deficient patients (n = 23), grouped by phenotype: SCID, n = 3; LS, n = 3; OS, n = 5; CID-G/AI, n = 11; and TCL, n = 1. (D) Detection of anti–IFN-α-2A, –IFN-ω, and –IL-12p70 antibodies by ELISA. Plasma samples were assayed for IgG autoantibodies at a 200-fold dilution. RAG-deficient patients included those with SCID (n = 2); LS (n = 3); OS (n = 3); CID-G/AI (n = 9); and TCL (n = 1). In both C and D, floating bars indicate the range of values for each autoantibody in healthy controls (n = 15 in C; n = 6 in D).
For further validation and characterization, a larger set of plasma samples from 23 patients with RAG mutations (CID-G/AI, n = 11; TCL, n = 1; OS, n = 5; LS, n = 3; SCID, n = 3) and from 15 healthy controls was tested for the presence of anti-cytokine antibodies using multiplex bead technology (Supplemental Table 5). Among the 25 distinct target cytokines tested, antibodies against IFN-α and IFN-ω were present in the majority of patients with CID-G/AI (7 of 11, 63.6%), TCL (1/1), and LS (2 of 3, 66%), but were less frequently detected in patients with OS (1 of 5, 20%) and SCID (1 of 3, 33.3%). By contrast, none of the 15 healthy controls had detectable antibodies against IFN-α or IFN-ω. In addition, antibodies targeting IL-12, IL-22, TNF-α, IFN-γ, and IL-6 were seen in a minority of patients (Figure 2C). Of note, the anti–TNF-α autoantibodies detected in patients CID-12 and CID-14 likely reflected prior treatment with infliximab, a chimeric monoclonal antibody against TNF-α. Of the 2 patients with anti–IFN-γ antibodies, CID-12 had chronic mycobacterial infection prior to HCT. Most of the anti-cytokine antibodies detected were of the IgG1 isotype (data not shown). None of the patients had antibodies against BAFF as determined by the extended protein microarray (generated in Dr. Utz’s laboratory at Stanford University) (Supplemental Table 4).
The presence of anti–IFN-α, –IFN-ω, and –IL-12 antibodies was further validated by ELISA in a subgroup of 18 RAG-deficient patients from whom samples were available for testing (CID-G/AI, n = 9; TCL, n = 1; OS, n = 3; LS, n = 3; SCID, n = 2; Figure 2D and Table 1), and the correlation with the results of autoantibody testing by multiplex bead assay is shown in Supplemental Figure 5.
To investigate whether use of IVIG may contribute to increased levels of anti-cytokine antibodies in RAG-deficient patients on Ig replacement therapy, we used ELISA to analyze anti–IFN-α, anti–IFN-ω, and anti–IL-12 antibody levels in 5 IVIG preparations diluted to a final concentration of 600 mg/dl IgG. Significantly lower levels of anti-cytokine antibodies were detected in the IVIG preparations as compared with serum levels in patients with RAG deficiency and a CID-G/AI phenotype (n = 8) and in 1 patient with OS (Supplemental Figure 6).
To assess whether a similar pattern of anti-cytokine antibodies may also be observed in other PIDs, we applied multiplex bead technology to study the presence of anti-cytokine antibodies in the plasma of patients with partial DiGeorge syndrome (n = 19), chronic granulomatous disease (CGD) (n = 7), and other PIDs (common variable immunodeficiency [CVID], n = 8; polysaccharide antibody deficiency, n = 3; ataxia-telangiectasia, n = 3). IgG autoantibodies targeting granulocyte CSF (G-CSF) and IFN-γ were detected in 3 patients with partial DiGeorge syndrome, and TNF-α and IFN-γ antibodies were detected in 2 patients with CGD. One patient with ataxia-telangiectasia had a combination of anti–IFN-α and anti–IFN-ω antibodies. In summary, patients with a PID other than RAG deficiency are also found to have anti-cytokine antibodies — but not to the degree found in patients with RAG mutations — and with a different signature of antigen specificity.
Finally, we searched for IgM antibodies against various cytokines (IFN-α, IFN-ω, IL-17, and IL-22) in plasma from 4 CID-G/AI patients (CID-2, -3, -9, and -12); 2 LS patients (LS-6 and -7); and 1 OS (OS-11) patient, all of whom had tested positive for IFN-α and/or IFN-ω IgG antibodies. Only low levels of IgM autoantibodies were detected, comparable to what we observed in healthy controls (n = 9) (data not shown).
In summary, anti-cytokine antibodies were analyzed by 1 or more of 3 methods (autoantigen protein microarray, multiplex bead assay, ELISA) in plasma from 23 patients with RAG mutations, 15 of whom had also been tested for conventional autoantibodies. The results consistently identified a distinctive signature of IgG anti-cytokine antibodies, especially in patients with CID-G/AI.
Anti-cytokine antibodies in patients with RAG-dependent immunodeficiencies have neutralizing activity. To study the possible biological role of the anti-cytokine antibodies detected, we evaluated their neutralizing activity in a subset of patients for whom we had sufficient plasma available. We assessed the ability of plasma from healthy donors or from RAG-deficient patients containing anti-cytokine autoantibodies to prevent either phosphorylation of the STAT molecules STAT1, -3, and -4 upon stimulation of peripheral blood mononuclear cells (PBMCs) with the appropriate cytokines (IFN-α, IFN-ω, IFN-γ, IL-22, and IL-12), or induction of thymocyte antigen 1 (Thy1) surface expression in Jurkat 3T8 cells upon stimulation with TNF-α. Data on the presence and neutralizing activity of anti-cytokine antibodies are summarized in Supplemental Table 6, and representative panels are shown in Figure 3, A–D, for each anti-cytokine antibody tested.
Figure 3Neutralizing activity of anti-cytokine antibodies. (A) Neutralizing activity of anti–IFN-α, anti–IFN-γ, and anti–IFN-ω antibodies. Normal PBMCs were incubated in the presence of plasma from a healthy control (left panel) or from a RAG-deficient patient (right panel), and left unstimulated or stimulated with either IFN-α, IFN-γ, or IFN-ω. STAT1 phosphorylation was measured by flow cytometry. The neutralizing effect of plasma from patient CID-12 on IFN-α (red), and IFN-ω (green), but not on IFN-γ (blue), is shown as a representative example. (B) Neutralizing activity of anti–IL-12p70 antibodies. Normal lymphoblasts were incubated in the presence of plasma from a healthy control (left panel) or from RAG-deficient patient CID-1 as a representative example (right panel) and left unstimulated or stimulated with IL-12p70. STAT4 phosphorylation was measured by flow cytometry. (C) Neutralizing activity of anti–IL-22 autoantibodies. A549 adenocarcinomic human alveolar basal epithelial cells were incubated in the presence of plasma from a healthy control (left panel) or from RAG-deficient patient CID-1 as a representative example (right panel) and left unstimulated or stimulated with IL-22. STAT3 phosphorylation was measured by flow cytometry. (D) Neutralizing activity of anti–TNF-α antibodies. Jurkat 3T8 cells were incubated in the presence of plasma from a healthy control (left panel) or from RAG-deficient patient CID-12 as a representative example (right panel) and left unstimulated or stimulated with TNF-α overnight. Thy1 surface expression was measured by flow cytometry.
In particular, except for patient SCID-3 with a low titer of anti–IFN-α antibodies, all other plasma samples containing anti–IFN-α autoantibodies (6 of 6 CID-G/AI, 1 of 1 TCL, 2 of 2 LS, and 1 of 1 OS) inhibited IFN-α–induced STAT1 phosphorylation (Figure 3A and Supplemental Table 6). Similarly, all but 1 of the samples containing anti–IFN-ω antibodies (5 of 5 CID-G/AI, 1 of 1 TCL, 2 of 2 LS, and 0 of 1 OS) blocked IFN-ω–induced STAT1 phosphorylation (Figure 3A and Supplemental Table 6). In 3 patients with anti–IL-12 antibodies (2 patients with CID-G/AI and 1 patient with TCL), plasma from patient CID-1 completely prevented IL-12–induced STAT4 phosphorylation (Figure 3B), while samples from the patient with TCL and from patient CID-9 were partially neutralizing or failed to neutralize IL-12, respectively (Supplemental Table 6). Anti–IL-22 autoantibodies were detected in 2 patients; in the case of patient CID-1, anti–IL-22 antibodies were fully neutralizing (Figure 3C), whereas patient LS-7 had anti–IL-22 antibodies at low titers, and their neutralizing activity could not be tested. The anti–TNF-α antibodies detected in 2 patients with CID-G/AI were neutralizing as determined by TNF-α–induced Thy1 surface expression in Jurkat 3T8 cells (Figure 3D). Finally, the anti–IFN-γ antibodies detected in patients CID-12 and OS-5 did not demonstrate neutralizing activity as determined by the STAT1 phosphorylation assay (Supplemental Table 6). These results show that the anti-cytokine antibodies were antagonistic and could substantially reduce signaling via engagement of the respective cytokine receptors.
Anti-cytokine antibodies are associated with severe viral infections in patients with RAG-dependent immunodeficiencies. To investigate possible triggers of anti–IFN-α/ω antibodies, we searched the medical records for relevant clinical commonalities and found that 4 of the 6 patients with CID-G/AI (patients CID-2, -3, -9, and -13) and the single patient with TCL with neutralizing anti–IFN-α/ω antibodies had a history of severe varicella. Furthermore, both patients with LS and neutralizing anti–IFN-α antibodies (LS-6 and LS-7) had histories of CMV infection, and 1 patient (LS-7) also experienced adenovirus infection, which had also been recorded in the single patient with OS (OS-11) with anti–IFN-α/ω antibodies (Table 1 and Supplemental Table 1). Of note, in patients TCL-1 and CID-9, anti-cytokine antibodies persisted for many years after complicated varicella infection (Supplemental Table 1). In summary, the majority of subjects with significant levels of anti-cytokine antibodies had a history of severe viral infections. In order to determine whether severe varicella infection alone could be associated with the presence of anti-cytokine antibodies, regardless of RAG deficiency, we tested plasma samples from 5 patients with a previous history of severe varicella infection and a lack of obvious immunodeficiency (n = 1) or the presence of other, non–RAG-dependent, forms of PID (n = 4), including 2 patients with ORAI1 deficiency, 1 patient with DOCK2 deficiency, and 1 patient with SCID with an unknown genetic defect. None of these patients had detectable levels of anti-cytokine antibodies. This result suggests that a history of varicella infection alone is not sufficient to elicit anti-cytokine antibodies in patients with immunodeficiencies other than RAG deficiency.
Repeated TLR3/MDA5 stimulation increases autoantibody production in a mouse model of LS due to Rag1 mutation. The occurrence of autoimmune cytopenias has been previously reported in patients with LS due to RAG mutations and CMV infection (6, 7), and our new data confirm that autoantibodies (including anti-cytokine antibodies) are more commonly detected in patients with RAG mutations with a history of viral infections. Previous work in mice has shown that high-dose administration of poly(I:C), a ligand for TLR3/MDA5 that mimics viral infection, results in increased innate immune responses in multiple models of immune deficiency (22). Furthermore, TLR3/MDA5, TLR7/-8, or TLR9 engagement converts T lymphocyte autoreactivity into overt autoimmune disease in a T lymphocyte–dependent murine model of diabetes (23). On the basis of these observations, we tested the hypothesis that repeated stimulation of TLR viral sensors may trigger autoantibody production in a mouse model with hypomorphic Rag mutations. We injected low doses of TLR3, TLR7/-8, and TLR9 agonists (or PBS as a negative control) i.p. weekly for 12 weeks into 6- to 8-week-old mice with a homozygous Rag1 S723C mutation (mut/mut mice, a model of LS) (15, 24) and their wild-type (WT) littermates. After the 12-week period of weekly injections, the mice were tested for the presence of autoantibodies in the plasma using a microarray similar to that used to analyze the presence of autoantibodies in patients. As shown in Figure 4A, a subset of mut/mut mice (8 of 15, 53.3%) produced autoantibodies even at baseline, confirming previous data of immune dysregulation in this model of LS (15, 16). Within 12 weeks after the initiation of weekly injections of TLR3/MDA5, TLR7/-8, and TLR9 agonists, an increase in the frequency and spectrum of IgM and IgG autoantibodies produced was observed in mut/mut mice compared with WT mice (Figure 4, A and B). A trend toward higher levels of autoantibodies against various antigens, including single-stranded DNA (ssDNA), double-stranded DNA (dsDNA), chromatin, histone, and Ro/SSA, was observed in poly(I:C)-treated mut/mut mice as demonstrated by higher signal intensity (Supplemental Figure 7, A and B). In comparison, autoantibody polyreactivity was not observed at baseline or after treatment with PBS in WT mice. Some autoantibody production was observed upon injection of CpG or R848 into WT mice, but only 1 of 5 (20%) sera samples from poly(I:C)-treated WT mice showed polyreactivity (Figure 4B). Increased levels of dsDNA and ssDNA autoantibodies in mut/mut mice at baseline, and even more so after repeated poly(I:C) injection, were confirmed by ELISA (Figure 4C and Supplemental Figure 8). The kinetics of anti-ssDNA and -dsDNA autoantibody production in mut/mut mice at intermediate time points (weeks 4 and 8) after initiation of TLR/MDA5 agonist injection is shown in Supplemental Figure 9. Anti-cytokine antibodies targeting IFN-α, IFN-ω, or IL-12 were not detected by ELISA in any of the mice, either spontaneously or after injection of TLR agonists (data not shown). In summary, these results demonstrate that repeated triggering of innate viral sensors (and TLR3/MDA5 in particular) elicits and/or increases multiple autoantibody levels in Rag-mutated mice but not in controls.
Figure 4Autoantibody reactivity in Rag1S723C/S723C (mut/mut) mice after stimulation with TLR3/MDA5, TLR7/-8, and TLR9 agonists. (A) Detection of IgG autoantibodies by protein microarray. Six- to eight-week-old mut/mut and WT/WT mice received a weekly i.p. injection of either PBS, low-dose poly(I:C), R848, or CpG. The presence of IgG antibodies against self-antigens in plasma samples was determined at day 0 and week 12 of treatment. Plasma pooled from lupus-prone NZM/MRL mice served as a positive control. Scale bars represent the MFI fold increase (blue to yellow) of autoantibody reactivity as compared with the mean + 2 SDs of the MFI in samples from WT/WT mice. (B) Frequency of autoantibodies in mut/mut mice after TLR/MDA5 stimulation. Multireactive samples were defined as containing autoantibodies against greater than or equal to 20% of 76 self-antigens. Wilcoxon test with Holm’s correction was used to compare results in WT/WT and mut/mut mice at baseline (week 0) and for each of the treatments and approached significance at week 0 (P = 0.0101). When comparing each of the 4 treatments with week 0 separately in WT/WT and in mut/mut mice, only CpG in WT/WT mice was significantly different (P = 0.0036). (C) Validation of dsDNA antibodies by ELISA. Plasma samples were diluted 200-fold. Wilcoxon test with Holm’s correction was used to compare results in WT/WT and mut/mut mice at baseline (week 0) and for each of the treatments as well as to compare each of the 4 treatments with week 0 separately in WT/WT and mut/mut mice. Results from 3 separate experiments were pooled.
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