High avidity cytokine autoantibodies in health and disease: pathogenesis and mechanisms

M Watanabe, K Uchida, K Nakagaki… - Cytokine & growth factor …, 2010 - Elsevier
Numerous reports have documented the presence of autoantibodies working against
naturally occurring cytokines in humans in health and disease. In most instances, their
physiological and pathophysiological significance remains unknown. However, recent
advances in the methodologies for detecting cytokine autoantibodies and their application in
research focused on specific disorders have shown that some cytokine autoantibodies play
an important role in the pathogenesis of disease. Additionally, levels of cytokine …