Usage Information

Regulation of dendritic cell activation by microRNA let-7c and BLIMP1
Sun Jung Kim, … , Peter K. Gregersen, Betty Diamond
Sun Jung Kim, … , Peter K. Gregersen, Betty Diamond
Published January 9, 2013
Citation Information: J Clin Invest. 2013;123(2):823-833. https://doi.org/10.1172/JCI64712.
View: Text | PDF
Research Article Autoimmunity

Regulation of dendritic cell activation by microRNA let-7c and BLIMP1

Abstract

Mice with a DC-specific deletion of the transcriptional repressor B lymphocyte–induced maturation protein-1 (Blimp1) exhibit a lupus-like phenotype, secondary to enhanced DC production of IL-6. Here we explored further phenotypic changes in Blimp1-deficient DCs, the molecular mechanism underlying these changes, and their relevance to human disease. Blimp1-deficient DCs exhibited elevated expression of MHC II, and exposure to TLR agonists increased secretion of proinflammatory cytokines. This phenotype reflects enhanced expression of the microRNA let-7c, which is regulated by BLIMP1. Let-7c reciprocally inhibited Blimp1 and also blocked LPS-induced suppressor of cytokine signaling-1 (SOCS1) expression, contributing to the proinflammatory phenotype of Blimp1-deficient DCs. DCs from Blimp1 SLE-risk allele carriers exhibited analogous phenotypic changes, including decreased BLIMP1 expression, increased let-7c expression, and increased expression of proinflammatory cytokines. These results suggest that let-7c regulates DC phenotype and confirm the importance of BLIMP1 in maintaining tolerogenic DCs in both mice and humans.

Authors

Sun Jung Kim, Peter K. Gregersen, Betty Diamond

×

Usage data is cumulative from July 2024 through July 2025.

Usage JCI PMC
Text version 465 50
PDF 96 25
Figure 407 9
Table 48 0
Supplemental data 41 1
Citation downloads 82 0
Totals 1,139 85
Total Views 1,224
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement