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Usage Information

Rapalogs and mTOR inhibitors as anti-aging therapeutics
Dudley W. Lamming, Lan Ye, David M. Sabatini, Joseph A. Baur
Dudley W. Lamming, Lan Ye, David M. Sabatini, Joseph A. Baur
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Review Series

Rapalogs and mTOR inhibitors as anti-aging therapeutics

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Abstract

Rapamycin, an inhibitor of mechanistic target of rapamycin (mTOR), has the strongest experimental support to date as a potential anti-aging therapeutic in mammals. Unlike many other compounds that have been claimed to influence longevity, rapamycin has been repeatedly tested in long-lived, genetically heterogeneous mice, in which it extends both mean and maximum life spans. However, the mechanism that accounts for these effects is far from clear, and a growing list of side effects make it doubtful that rapamycin would ultimately be beneficial in humans. This Review discusses the prospects for developing newer, safer anti-aging therapies based on analogs of rapamycin (termed rapalogs) or other approaches targeting mTOR signaling.

Authors

Dudley W. Lamming, Lan Ye, David M. Sabatini, Joseph A. Baur

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Usage data is cumulative from March 2025 through March 2026.

Usage JCI PMC
Text version 4,024 606
PDF 202 69
Figure 390 6
Table 254 0
Citation downloads 132 0
Totals 5,002 681
Total Views 5,683
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

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