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Usage Information

The therapeutic promise of the cancer stem cell concept
Natasha Y. Frank, … , Tobias Schatton, Markus H. Frank
Natasha Y. Frank, … , Tobias Schatton, Markus H. Frank
Published January 4, 2010
Citation Information: J Clin Invest. 2010;120(1):41-50. https://doi.org/10.1172/JCI41004.
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Review Series

The therapeutic promise of the cancer stem cell concept

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Abstract

Cancer stem cells (CSCs) are a subpopulation of tumor cells that selectively possess tumor initiation and self-renewal capacity and the ability to give rise to bulk populations of nontumorigenic cancer cell progeny through differentiation. As we discuss here, they have been prospectively identified in several human malignancies, and their relative abundance in clinical cancer specimens has been correlated with malignant disease progression in human patients. Furthermore, recent findings suggest that clinical cancer progression driven by CSCs may contribute to the failure of existing therapies to consistently eradicate malignant tumors. Therefore, CSC-directed therapeutic approaches might represent translationally relevant strategies to improve clinical cancer therapy, in particular for those malignancies that are currently refractory to conventional anticancer agents directed predominantly at tumor bulk populations.

Authors

Natasha Y. Frank, Tobias Schatton, Markus H. Frank

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Usage data is cumulative from July 2024 through July 2025.

Usage JCI PMC
Text version 1,921 206
PDF 95 31
Figure 204 1
Table 46 0
Citation downloads 82 0
Totals 2,348 238
Total Views 2,586
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

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