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Usage Information

CD4+ Tregs and immune control
Zoltán Fehérvari, Shimon Sakaguchi
Zoltán Fehérvari, Shimon Sakaguchi
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CD4+ Tregs and immune control

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Abstract

Recent years have seen Tregs become a popular subject of immunological research. Abundant experimental data have now confirmed that naturally occurring CD25+CD4+ Tregs in particular play a key role in the maintenance of self tolerance, with their dysfunction leading to severe or even fatal immunopathology. The sphere of influence of Tregs is now known to extend well beyond just the maintenance of immunological tolerance and to impinge on a host of clinically important areas from cancer to infectious diseases. The identification of specific molecular markers in both human and murine immune systems has enabled the unprecedented investigation of these cells and should prove key to ultimately unlocking their clinical potential.

Authors

Zoltán Fehérvari, Shimon Sakaguchi

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Usage data is cumulative from June 2025 through June 2026.

Usage JCI PMC
Text version 1,485 76
PDF 274 15
Figure 382 2
Table 94 0
Citation downloads 155 0
Totals 2,390 93
Total Views 2,483
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ISSN: 0021-9738 (print), 1558-8238 (online)

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