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ResearchIn-Press PreviewCell biologyNeuroscience
Open Access | 
10.1172/JCI206862
Distinct parafascicular neuronal ensembles mediate the sensory and affective dimensions of trigeminal neuralgia
Yitian Lu,1 Yangyang Yi,2 Jiao Liu,3 Hao Zhi,1 Qing Chang,1 Zihao Huang,1 Yumeng Chen,1 Han L. Tan,4 Yiheng Tu,2 Yun Wang,1 and Cheng Cen1
1Neuroscience Research Institute and Department of Neurobiology,, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing, China
2State Key Laboratory of Cognitive Science and Mental Health, nstitute of Psychology, Chinese Academy of Science, Beijing, China
3Center of Medical and Health Analysis, Peking University Health Science Center, Beijing, China
4Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, United States of America
Find articles by Lu, Y. in: PubMed | Google Scholar
1Neuroscience Research Institute and Department of Neurobiology,, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing, China
2State Key Laboratory of Cognitive Science and Mental Health, nstitute of Psychology, Chinese Academy of Science, Beijing, China
3Center of Medical and Health Analysis, Peking University Health Science Center, Beijing, China
4Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, United States of America
Find articles by Yi, Y. in: PubMed | Google Scholar
1Neuroscience Research Institute and Department of Neurobiology,, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing, China
2State Key Laboratory of Cognitive Science and Mental Health, nstitute of Psychology, Chinese Academy of Science, Beijing, China
3Center of Medical and Health Analysis, Peking University Health Science Center, Beijing, China
4Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, United States of America
Find articles by Liu, J. in: PubMed | Google Scholar
1Neuroscience Research Institute and Department of Neurobiology,, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing, China
2State Key Laboratory of Cognitive Science and Mental Health, nstitute of Psychology, Chinese Academy of Science, Beijing, China
3Center of Medical and Health Analysis, Peking University Health Science Center, Beijing, China
4Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, United States of America
Find articles by Zhi, H. in: PubMed | Google Scholar
1Neuroscience Research Institute and Department of Neurobiology,, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing, China
2State Key Laboratory of Cognitive Science and Mental Health, nstitute of Psychology, Chinese Academy of Science, Beijing, China
3Center of Medical and Health Analysis, Peking University Health Science Center, Beijing, China
4Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, United States of America
Find articles by Chang, Q. in: PubMed | Google Scholar
1Neuroscience Research Institute and Department of Neurobiology,, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing, China
2State Key Laboratory of Cognitive Science and Mental Health, nstitute of Psychology, Chinese Academy of Science, Beijing, China
3Center of Medical and Health Analysis, Peking University Health Science Center, Beijing, China
4Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, United States of America
Find articles by Huang, Z. in: PubMed | Google Scholar
1Neuroscience Research Institute and Department of Neurobiology,, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing, China
2State Key Laboratory of Cognitive Science and Mental Health, nstitute of Psychology, Chinese Academy of Science, Beijing, China
3Center of Medical and Health Analysis, Peking University Health Science Center, Beijing, China
4Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, United States of America
Find articles by Chen, Y. in: PubMed | Google Scholar
1Neuroscience Research Institute and Department of Neurobiology,, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing, China
2State Key Laboratory of Cognitive Science and Mental Health, nstitute of Psychology, Chinese Academy of Science, Beijing, China
3Center of Medical and Health Analysis, Peking University Health Science Center, Beijing, China
4Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, United States of America
Find articles by Tan, H. in: PubMed | Google Scholar
1Neuroscience Research Institute and Department of Neurobiology,, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing, China
2State Key Laboratory of Cognitive Science and Mental Health, nstitute of Psychology, Chinese Academy of Science, Beijing, China
3Center of Medical and Health Analysis, Peking University Health Science Center, Beijing, China
4Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, United States of America
Find articles by Tu, Y. in: PubMed | Google Scholar
1Neuroscience Research Institute and Department of Neurobiology,, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing, China
2State Key Laboratory of Cognitive Science and Mental Health, nstitute of Psychology, Chinese Academy of Science, Beijing, China
3Center of Medical and Health Analysis, Peking University Health Science Center, Beijing, China
4Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, United States of America
Find articles by Wang, Y. in: PubMed | Google Scholar
1Neuroscience Research Institute and Department of Neurobiology,, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing, China
2State Key Laboratory of Cognitive Science and Mental Health, nstitute of Psychology, Chinese Academy of Science, Beijing, China
3Center of Medical and Health Analysis, Peking University Health Science Center, Beijing, China
4Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, United States of America
Find articles by Cen, C. in: PubMed | Google Scholar
Published July 14, 2026 - More info
Copyright © 2026, Lu et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)