Targeting lipidated amino acid deficiency mitigates fibrosis via a PPARα/CCL2 axis in metabolic dysfunction-associated steatohepatitis models

Sumit Kumar Anand; Sandeep Das; Fabio Arias; Koral S.E. Richard; Sumati Rohilla; Alia Ghrayeb; M. Peyton McKinney; Lu Wang; Lin Tan; Jibin Ding; Dhananjay Kumar; Nilesh Pandey; Jennifer Lee; Ying Zhao; Suman Mohajan; Gurranna Male; Kelley Nunez; Alexandra C. Finney; Brenna H. Pearson-Gallion; Reethika Gade; Jemiah Maxie; Yu Liu; Harpreet Kaur; Rajan Pandit; Cyrine Ben Dhaou; Joseph Eniafe; Xiaolu Zhang; Zhipeng Liu; Andrew D. Yurochko; Minerva T. Garcia-Barrio; Babak Razani; Fei Chang; Francisco J. Schopfer; Xin Huang; Bishuang Cai; Eyal Gottlieb; Bo Wen; Duxin Sun; Wanqing Liu; Paul T. Thevenot; Ari J. Cohen; Jifeng Zhang; Y. Eugene Chen; A. Wayne Orr; Nirav Dhanesha; Arif Yurdagul Jr.; Oren Rom

doi:10.1172/JCI204511

¹Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America

²Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, United States of America

³Metabolomics Core Facility, Department of Bioinformatics and Computational, The University of Texas MD Anderson Cancer Center, Houston, United States of America

⁴Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America

⁵Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Medical School, Ann Arbor, United States of America

⁶Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America

⁷Institute of Translational Research, Ochsner Clinic Foundation, New Orleans, United States of America

⁸Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Me, David Geffen School of Medicine at UCLA, Los Angeles, United States of America

⁹Department of Microbiology and Immunology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America

¹⁰Bioinformatics and Modeling Core, Department of Microbiology and Immunology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, United States of America

¹¹Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, United States of America

¹²Division of Cardiology and Vascular Medicine Institute, Department of Medic, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, United States of America

¹³Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America

¹⁴Division of Hematology-Oncology, Department of Medicine and Jonsson Compreh, David Geffen School of Medicine at UCLA, Los Angeles, United States of America

¹⁵Department of Pharmaceutical Sciences and Department of Pharmacology, Wayne State University, Detroit, United States of America

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