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ResearchIn-Press PreviewHepatologyInflammation
Open Access | 
10.1172/JCI201406
S100A11 regulates hepatic cholesterol metabolism and promotes steatohepatitis via non-canonical SREBP2 signaling
Mingfeng Zhan,1 Xiumei Xu,2 Huiyin Wu,1 Qijing Fan,1 Hongsheng Lu,1 Chengbin Li,1 Linqiang Zhang,3 Tingting Zhu,4 Yunqian Shen,1 Jing Liu,1 Yaomei He,1 Yingjie Wu,5 Jingjing Zhang,1 Xiaoju Zou,2 and Bin Liang1
1School of Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Disea, Yunnan University, Kunming, China
2College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Med, Yunnan University of Chinese Medicine, Kunming, China
3Institute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing, China
4School of Medicine, Guizhou University, Guizhou, China
5Institute for Genome Engineered Animal Models of Human Diseases, National C, Dalian Medical University, Dalian, China
Find articles by Zhan, M. in: PubMed | Google Scholar
1School of Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Disea, Yunnan University, Kunming, China
2College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Med, Yunnan University of Chinese Medicine, Kunming, China
3Institute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing, China
4School of Medicine, Guizhou University, Guizhou, China
5Institute for Genome Engineered Animal Models of Human Diseases, National C, Dalian Medical University, Dalian, China
Find articles by Xu, X. in: PubMed | Google Scholar
1School of Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Disea, Yunnan University, Kunming, China
2College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Med, Yunnan University of Chinese Medicine, Kunming, China
3Institute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing, China
4School of Medicine, Guizhou University, Guizhou, China
5Institute for Genome Engineered Animal Models of Human Diseases, National C, Dalian Medical University, Dalian, China
Find articles by Wu, H. in: PubMed | Google Scholar
1School of Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Disea, Yunnan University, Kunming, China
2College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Med, Yunnan University of Chinese Medicine, Kunming, China
3Institute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing, China
4School of Medicine, Guizhou University, Guizhou, China
5Institute for Genome Engineered Animal Models of Human Diseases, National C, Dalian Medical University, Dalian, China
Find articles by Fan, Q. in: PubMed | Google Scholar
1School of Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Disea, Yunnan University, Kunming, China
2College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Med, Yunnan University of Chinese Medicine, Kunming, China
3Institute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing, China
4School of Medicine, Guizhou University, Guizhou, China
5Institute for Genome Engineered Animal Models of Human Diseases, National C, Dalian Medical University, Dalian, China
Find articles by Lu, H. in: PubMed | Google Scholar
1School of Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Disea, Yunnan University, Kunming, China
2College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Med, Yunnan University of Chinese Medicine, Kunming, China
3Institute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing, China
4School of Medicine, Guizhou University, Guizhou, China
5Institute for Genome Engineered Animal Models of Human Diseases, National C, Dalian Medical University, Dalian, China
Find articles by Li, C. in: PubMed | Google Scholar
1School of Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Disea, Yunnan University, Kunming, China
2College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Med, Yunnan University of Chinese Medicine, Kunming, China
3Institute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing, China
4School of Medicine, Guizhou University, Guizhou, China
5Institute for Genome Engineered Animal Models of Human Diseases, National C, Dalian Medical University, Dalian, China
Find articles by Zhang, L. in: PubMed | Google Scholar
1School of Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Disea, Yunnan University, Kunming, China
2College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Med, Yunnan University of Chinese Medicine, Kunming, China
3Institute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing, China
4School of Medicine, Guizhou University, Guizhou, China
5Institute for Genome Engineered Animal Models of Human Diseases, National C, Dalian Medical University, Dalian, China
Find articles by Zhu, T. in: PubMed | Google Scholar
1School of Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Disea, Yunnan University, Kunming, China
2College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Med, Yunnan University of Chinese Medicine, Kunming, China
3Institute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing, China
4School of Medicine, Guizhou University, Guizhou, China
5Institute for Genome Engineered Animal Models of Human Diseases, National C, Dalian Medical University, Dalian, China
Find articles by Shen, Y. in: PubMed | Google Scholar
1School of Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Disea, Yunnan University, Kunming, China
2College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Med, Yunnan University of Chinese Medicine, Kunming, China
3Institute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing, China
4School of Medicine, Guizhou University, Guizhou, China
5Institute for Genome Engineered Animal Models of Human Diseases, National C, Dalian Medical University, Dalian, China
Find articles by Liu, J. in: PubMed | Google Scholar
1School of Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Disea, Yunnan University, Kunming, China
2College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Med, Yunnan University of Chinese Medicine, Kunming, China
3Institute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing, China
4School of Medicine, Guizhou University, Guizhou, China
5Institute for Genome Engineered Animal Models of Human Diseases, National C, Dalian Medical University, Dalian, China
Find articles by He, Y. in: PubMed | Google Scholar
1School of Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Disea, Yunnan University, Kunming, China
2College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Med, Yunnan University of Chinese Medicine, Kunming, China
3Institute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing, China
4School of Medicine, Guizhou University, Guizhou, China
5Institute for Genome Engineered Animal Models of Human Diseases, National C, Dalian Medical University, Dalian, China
Find articles by Wu, Y. in: PubMed | Google Scholar
1School of Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Disea, Yunnan University, Kunming, China
2College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Med, Yunnan University of Chinese Medicine, Kunming, China
3Institute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing, China
4School of Medicine, Guizhou University, Guizhou, China
5Institute for Genome Engineered Animal Models of Human Diseases, National C, Dalian Medical University, Dalian, China
Find articles by Zhang, J. in: PubMed | Google Scholar
1School of Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Disea, Yunnan University, Kunming, China
2College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Med, Yunnan University of Chinese Medicine, Kunming, China
3Institute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing, China
4School of Medicine, Guizhou University, Guizhou, China
5Institute for Genome Engineered Animal Models of Human Diseases, National C, Dalian Medical University, Dalian, China
Find articles by Zou, X. in: PubMed | Google Scholar
1School of Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Disea, Yunnan University, Kunming, China
2College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Med, Yunnan University of Chinese Medicine, Kunming, China
3Institute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing, China
4School of Medicine, Guizhou University, Guizhou, China
5Institute for Genome Engineered Animal Models of Human Diseases, National C, Dalian Medical University, Dalian, China
Find articles by Liang, B. in: PubMed | Google Scholar
Published August 4, 2026 - More info
Copyright © 2026, Zhan et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)