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ResearchIn-Press PreviewCell biologyOncology
Open Access | 
10.1172/JCI199483
Targeting casein kinase 1α-mediated FADD phosphorylation restores sensitivity in select CDK4/6 inhibitor-resistant breast cancer models
Sahezeel Awadia,1 Elizabeth K. Ziemke,2 Nicole M. Curnutt,3 Emily Kirk,4 Julianne Thomas,4 Anna Zimmerman,4 Maya J. Mileski,4 Sundaresh Ram,5 Reine Abou Zeidane,6 Craig Galban,2 Christina M. Woo,3 Corey W. Speers,7 Judith Leopold,2 and Alnawaz Rehemtulla4
1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, United States of America
2Department of Radiology, The University of Michigan Medical School, Ann Arbor, United States of America
3Department of Chemistry and Chemical Biology, Harvard University, Cambridge, United States of America
4Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, United States of America
5Department of Radiology and Imaging Sciences, Emory University and Georgia Institute of Technology, Atlanta, United States of America
6Department of Radiation Oncology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, United States of America
7Department of Radiation Oncology, The University of Alabama at Birmingham, Birmingham, United States of America
Find articles by Awadia, S. in: PubMed | Google Scholar
1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, United States of America
2Department of Radiology, The University of Michigan Medical School, Ann Arbor, United States of America
3Department of Chemistry and Chemical Biology, Harvard University, Cambridge, United States of America
4Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, United States of America
5Department of Radiology and Imaging Sciences, Emory University and Georgia Institute of Technology, Atlanta, United States of America
6Department of Radiation Oncology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, United States of America
7Department of Radiation Oncology, The University of Alabama at Birmingham, Birmingham, United States of America
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1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, United States of America
2Department of Radiology, The University of Michigan Medical School, Ann Arbor, United States of America
3Department of Chemistry and Chemical Biology, Harvard University, Cambridge, United States of America
4Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, United States of America
5Department of Radiology and Imaging Sciences, Emory University and Georgia Institute of Technology, Atlanta, United States of America
6Department of Radiation Oncology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, United States of America
7Department of Radiation Oncology, The University of Alabama at Birmingham, Birmingham, United States of America
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1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, United States of America
2Department of Radiology, The University of Michigan Medical School, Ann Arbor, United States of America
3Department of Chemistry and Chemical Biology, Harvard University, Cambridge, United States of America
4Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, United States of America
5Department of Radiology and Imaging Sciences, Emory University and Georgia Institute of Technology, Atlanta, United States of America
6Department of Radiation Oncology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, United States of America
7Department of Radiation Oncology, The University of Alabama at Birmingham, Birmingham, United States of America
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1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, United States of America
2Department of Radiology, The University of Michigan Medical School, Ann Arbor, United States of America
3Department of Chemistry and Chemical Biology, Harvard University, Cambridge, United States of America
4Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, United States of America
5Department of Radiology and Imaging Sciences, Emory University and Georgia Institute of Technology, Atlanta, United States of America
6Department of Radiation Oncology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, United States of America
7Department of Radiation Oncology, The University of Alabama at Birmingham, Birmingham, United States of America
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1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, United States of America
2Department of Radiology, The University of Michigan Medical School, Ann Arbor, United States of America
3Department of Chemistry and Chemical Biology, Harvard University, Cambridge, United States of America
4Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, United States of America
5Department of Radiology and Imaging Sciences, Emory University and Georgia Institute of Technology, Atlanta, United States of America
6Department of Radiation Oncology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, United States of America
7Department of Radiation Oncology, The University of Alabama at Birmingham, Birmingham, United States of America
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1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, United States of America
2Department of Radiology, The University of Michigan Medical School, Ann Arbor, United States of America
3Department of Chemistry and Chemical Biology, Harvard University, Cambridge, United States of America
4Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, United States of America
5Department of Radiology and Imaging Sciences, Emory University and Georgia Institute of Technology, Atlanta, United States of America
6Department of Radiation Oncology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, United States of America
7Department of Radiation Oncology, The University of Alabama at Birmingham, Birmingham, United States of America
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1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, United States of America
2Department of Radiology, The University of Michigan Medical School, Ann Arbor, United States of America
3Department of Chemistry and Chemical Biology, Harvard University, Cambridge, United States of America
4Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, United States of America
5Department of Radiology and Imaging Sciences, Emory University and Georgia Institute of Technology, Atlanta, United States of America
6Department of Radiation Oncology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, United States of America
7Department of Radiation Oncology, The University of Alabama at Birmingham, Birmingham, United States of America
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1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, United States of America
2Department of Radiology, The University of Michigan Medical School, Ann Arbor, United States of America
3Department of Chemistry and Chemical Biology, Harvard University, Cambridge, United States of America
4Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, United States of America
5Department of Radiology and Imaging Sciences, Emory University and Georgia Institute of Technology, Atlanta, United States of America
6Department of Radiation Oncology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, United States of America
7Department of Radiation Oncology, The University of Alabama at Birmingham, Birmingham, United States of America
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1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, United States of America
2Department of Radiology, The University of Michigan Medical School, Ann Arbor, United States of America
3Department of Chemistry and Chemical Biology, Harvard University, Cambridge, United States of America
4Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, United States of America
5Department of Radiology and Imaging Sciences, Emory University and Georgia Institute of Technology, Atlanta, United States of America
6Department of Radiation Oncology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, United States of America
7Department of Radiation Oncology, The University of Alabama at Birmingham, Birmingham, United States of America
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1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, United States of America
2Department of Radiology, The University of Michigan Medical School, Ann Arbor, United States of America
3Department of Chemistry and Chemical Biology, Harvard University, Cambridge, United States of America
4Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, United States of America
5Department of Radiology and Imaging Sciences, Emory University and Georgia Institute of Technology, Atlanta, United States of America
6Department of Radiation Oncology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, United States of America
7Department of Radiation Oncology, The University of Alabama at Birmingham, Birmingham, United States of America
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1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, United States of America
2Department of Radiology, The University of Michigan Medical School, Ann Arbor, United States of America
3Department of Chemistry and Chemical Biology, Harvard University, Cambridge, United States of America
4Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, United States of America
5Department of Radiology and Imaging Sciences, Emory University and Georgia Institute of Technology, Atlanta, United States of America
6Department of Radiation Oncology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, United States of America
7Department of Radiation Oncology, The University of Alabama at Birmingham, Birmingham, United States of America
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1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, United States of America
2Department of Radiology, The University of Michigan Medical School, Ann Arbor, United States of America
3Department of Chemistry and Chemical Biology, Harvard University, Cambridge, United States of America
4Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, United States of America
5Department of Radiology and Imaging Sciences, Emory University and Georgia Institute of Technology, Atlanta, United States of America
6Department of Radiation Oncology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, United States of America
7Department of Radiation Oncology, The University of Alabama at Birmingham, Birmingham, United States of America
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1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, United States of America
2Department of Radiology, The University of Michigan Medical School, Ann Arbor, United States of America
3Department of Chemistry and Chemical Biology, Harvard University, Cambridge, United States of America
4Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, United States of America
5Department of Radiology and Imaging Sciences, Emory University and Georgia Institute of Technology, Atlanta, United States of America
6Department of Radiation Oncology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, United States of America
7Department of Radiation Oncology, The University of Alabama at Birmingham, Birmingham, United States of America
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Published July 28, 2026 - More info
Copyright © 2026, Awadia et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)