(A) Mean and participant-level trough-adjusted C-peptide AUC at 120 minutes into 240-minute MMTTs at baseline and weeks 24 and 48. All participants improved (green dots), except 1 per-protocol and 2 ITT participants (black dots). Asterisk denotes overlapping data points (both green). The y axis scales differ between graphs due to single ITT outlier. (B) Mean C-peptide levels during MMTTs at baseline and weeks 24 and 48 (95% CIs are provided in the Supporting Data Values file). (C and D) Summary and participant-level data for secondary glycemic control measures: HbA1c (C) and time in target glucose range (D; 70–180 mg/dL). (E) Best-corrected visual acuity (BCVA) as assessed by logarithm of the minimum angle of resolution (LogMAR) in the best eye. (F) Symptom burden at weeks 24 and 48 assessed via PGI-C and CGI-C. All measured participants were responders (defined by ratings of minimally, much, or very much improved or no change). Means (bars), 95% CIs (error bars), and mean changes (brackets) are shown in A and C–E. In participant-level data, green indicates improved or stable, and black indicates others. Single asterisks denote overlapping points of same color; double asterisks denote 1 green and 1 black.