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ResearchIn-Press PreviewCell biologyHepatology
Open Access | 
10.1172/JCI197923
RNA-binding protein LARP6 coordinates hepatic stellate cell activation and liver fibrosis
Hyun Young Kim,1 Orel Mizrahi,2 Wonseok Lee,1 Sara B. Rosenthal,3 Cuijuan Han,1 Brian A. Yee,2 Steven M. Blue,2 Jesiel Diaz,2 Jyotiprakash P. Jonnalagadda,2 Lena A. Street,4 Kanani Hokutan,1 Haeum Jang,1 Charlene Miciano,2 Chen-Ting Ma,5 Andrey A. Bobkov,5 Eduard Sergienko,5 Michael R. Jackson,5 Marko Jovanovic,4 Branko Stefanovic,6 Tatiana Kisseleva,7 Gene W. Yeo,2 and David A. Brenner8
1Department of Medicine, University of California San Diego, La Jolla, United States of America
2Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
3Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, United States of America
4Department of Biological Sciences, Columbia University, New York, United States of America
5Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
6Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, United States of America
7Department of Surgery, University of California San Diego, La Jolla, United States of America
8Department of Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
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1Department of Medicine, University of California San Diego, La Jolla, United States of America
2Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
3Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, United States of America
4Department of Biological Sciences, Columbia University, New York, United States of America
5Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
6Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, United States of America
7Department of Surgery, University of California San Diego, La Jolla, United States of America
8Department of Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
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1Department of Medicine, University of California San Diego, La Jolla, United States of America
2Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
3Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, United States of America
4Department of Biological Sciences, Columbia University, New York, United States of America
5Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
6Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, United States of America
7Department of Surgery, University of California San Diego, La Jolla, United States of America
8Department of Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
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1Department of Medicine, University of California San Diego, La Jolla, United States of America
2Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
3Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, United States of America
4Department of Biological Sciences, Columbia University, New York, United States of America
5Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
6Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, United States of America
7Department of Surgery, University of California San Diego, La Jolla, United States of America
8Department of Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
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1Department of Medicine, University of California San Diego, La Jolla, United States of America
2Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
3Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, United States of America
4Department of Biological Sciences, Columbia University, New York, United States of America
5Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
6Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, United States of America
7Department of Surgery, University of California San Diego, La Jolla, United States of America
8Department of Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
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1Department of Medicine, University of California San Diego, La Jolla, United States of America
2Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
3Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, United States of America
4Department of Biological Sciences, Columbia University, New York, United States of America
5Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
6Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, United States of America
7Department of Surgery, University of California San Diego, La Jolla, United States of America
8Department of Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
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1Department of Medicine, University of California San Diego, La Jolla, United States of America
2Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
3Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, United States of America
4Department of Biological Sciences, Columbia University, New York, United States of America
5Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
6Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, United States of America
7Department of Surgery, University of California San Diego, La Jolla, United States of America
8Department of Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
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1Department of Medicine, University of California San Diego, La Jolla, United States of America
2Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
3Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, United States of America
4Department of Biological Sciences, Columbia University, New York, United States of America
5Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
6Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, United States of America
7Department of Surgery, University of California San Diego, La Jolla, United States of America
8Department of Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
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1Department of Medicine, University of California San Diego, La Jolla, United States of America
2Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
3Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, United States of America
4Department of Biological Sciences, Columbia University, New York, United States of America
5Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
6Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, United States of America
7Department of Surgery, University of California San Diego, La Jolla, United States of America
8Department of Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
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1Department of Medicine, University of California San Diego, La Jolla, United States of America
2Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
3Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, United States of America
4Department of Biological Sciences, Columbia University, New York, United States of America
5Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
6Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, United States of America
7Department of Surgery, University of California San Diego, La Jolla, United States of America
8Department of Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
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1Department of Medicine, University of California San Diego, La Jolla, United States of America
2Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
3Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, United States of America
4Department of Biological Sciences, Columbia University, New York, United States of America
5Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
6Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, United States of America
7Department of Surgery, University of California San Diego, La Jolla, United States of America
8Department of Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
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1Department of Medicine, University of California San Diego, La Jolla, United States of America
2Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
3Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, United States of America
4Department of Biological Sciences, Columbia University, New York, United States of America
5Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
6Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, United States of America
7Department of Surgery, University of California San Diego, La Jolla, United States of America
8Department of Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
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1Department of Medicine, University of California San Diego, La Jolla, United States of America
2Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
3Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, United States of America
4Department of Biological Sciences, Columbia University, New York, United States of America
5Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
6Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, United States of America
7Department of Surgery, University of California San Diego, La Jolla, United States of America
8Department of Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
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1Department of Medicine, University of California San Diego, La Jolla, United States of America
2Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
3Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, United States of America
4Department of Biological Sciences, Columbia University, New York, United States of America
5Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
6Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, United States of America
7Department of Surgery, University of California San Diego, La Jolla, United States of America
8Department of Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
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1Department of Medicine, University of California San Diego, La Jolla, United States of America
2Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
3Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, United States of America
4Department of Biological Sciences, Columbia University, New York, United States of America
5Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
6Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, United States of America
7Department of Surgery, University of California San Diego, La Jolla, United States of America
8Department of Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
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1Department of Medicine, University of California San Diego, La Jolla, United States of America
2Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
3Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, United States of America
4Department of Biological Sciences, Columbia University, New York, United States of America
5Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
6Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, United States of America
7Department of Surgery, University of California San Diego, La Jolla, United States of America
8Department of Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
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1Department of Medicine, University of California San Diego, La Jolla, United States of America
2Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
3Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, United States of America
4Department of Biological Sciences, Columbia University, New York, United States of America
5Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
6Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, United States of America
7Department of Surgery, University of California San Diego, La Jolla, United States of America
8Department of Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
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1Department of Medicine, University of California San Diego, La Jolla, United States of America
2Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
3Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, United States of America
4Department of Biological Sciences, Columbia University, New York, United States of America
5Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
6Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, United States of America
7Department of Surgery, University of California San Diego, La Jolla, United States of America
8Department of Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
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1Department of Medicine, University of California San Diego, La Jolla, United States of America
2Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
3Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, United States of America
4Department of Biological Sciences, Columbia University, New York, United States of America
5Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
6Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, United States of America
7Department of Surgery, University of California San Diego, La Jolla, United States of America
8Department of Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
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2Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
3Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, United States of America
4Department of Biological Sciences, Columbia University, New York, United States of America
5Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
6Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, United States of America
7Department of Surgery, University of California San Diego, La Jolla, United States of America
8Department of Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
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1Department of Medicine, University of California San Diego, La Jolla, United States of America
2Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
3Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, United States of America
4Department of Biological Sciences, Columbia University, New York, United States of America
5Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
6Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, United States of America
7Department of Surgery, University of California San Diego, La Jolla, United States of America
8Department of Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
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1Department of Medicine, University of California San Diego, La Jolla, United States of America
2Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
3Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, United States of America
4Department of Biological Sciences, Columbia University, New York, United States of America
5Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
6Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, United States of America
7Department of Surgery, University of California San Diego, La Jolla, United States of America
8Department of Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
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Published February 26, 2026 - More info
Copyright © 2026, Kim et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)