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Research LetterIn-Press PreviewHematologyInflammationMetabolism
Open Access | 
10.1172/JCI197100
Clonal hematopoiesis driven by Dnmt3a mutations promotes metabolic disease development in mice
Bowen Yan,1 Qingchen Yuan,1 Marco M. Buttigieg,2 Prabhjot Kaur,1 Annalisse R. McKee,1 Daniil E. Shabashvili,1 Caitlyn Vlasschaert,2 Alexander G. Bick,4 Michael J. Rauh,5 and Olga A. Guryanova6
1University of Florida College of Medicine, Gainesville, United States of America
2Queen's University, Kingston, Canada
3Queen's University, Kingston, United States of America
4Vanderbilt University Medical Center, Nashville, United States of America
5Pathology and Molecular Medicine, Queen's University, Kingston, Canada
6Department Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, United States of America
Find articles by Yan, B. in: PubMed | Google Scholar
1University of Florida College of Medicine, Gainesville, United States of America
2Queen's University, Kingston, Canada
3Queen's University, Kingston, United States of America
4Vanderbilt University Medical Center, Nashville, United States of America
5Pathology and Molecular Medicine, Queen's University, Kingston, Canada
6Department Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, United States of America
Find articles by Yuan, Q. in: PubMed | Google Scholar
1University of Florida College of Medicine, Gainesville, United States of America
2Queen's University, Kingston, Canada
3Queen's University, Kingston, United States of America
4Vanderbilt University Medical Center, Nashville, United States of America
5Pathology and Molecular Medicine, Queen's University, Kingston, Canada
6Department Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, United States of America
Find articles by Buttigieg, M. in: PubMed | Google Scholar
1University of Florida College of Medicine, Gainesville, United States of America
2Queen's University, Kingston, Canada
3Queen's University, Kingston, United States of America
4Vanderbilt University Medical Center, Nashville, United States of America
5Pathology and Molecular Medicine, Queen's University, Kingston, Canada
6Department Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, United States of America
Find articles by Kaur, P. in: PubMed | Google Scholar
1University of Florida College of Medicine, Gainesville, United States of America
2Queen's University, Kingston, Canada
3Queen's University, Kingston, United States of America
4Vanderbilt University Medical Center, Nashville, United States of America
5Pathology and Molecular Medicine, Queen's University, Kingston, Canada
6Department Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, United States of America
Find articles by McKee, A. in: PubMed | Google Scholar
1University of Florida College of Medicine, Gainesville, United States of America
2Queen's University, Kingston, Canada
3Queen's University, Kingston, United States of America
4Vanderbilt University Medical Center, Nashville, United States of America
5Pathology and Molecular Medicine, Queen's University, Kingston, Canada
6Department Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, United States of America
Find articles by Shabashvili, D. in: PubMed | Google Scholar
1University of Florida College of Medicine, Gainesville, United States of America
2Queen's University, Kingston, Canada
3Queen's University, Kingston, United States of America
4Vanderbilt University Medical Center, Nashville, United States of America
5Pathology and Molecular Medicine, Queen's University, Kingston, Canada
6Department Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, United States of America
Find articles by Vlasschaert, C. in: PubMed | Google Scholar
1University of Florida College of Medicine, Gainesville, United States of America
2Queen's University, Kingston, Canada
3Queen's University, Kingston, United States of America
4Vanderbilt University Medical Center, Nashville, United States of America
5Pathology and Molecular Medicine, Queen's University, Kingston, Canada
6Department Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, United States of America
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Bick, A.
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1University of Florida College of Medicine, Gainesville, United States of America
2Queen's University, Kingston, Canada
3Queen's University, Kingston, United States of America
4Vanderbilt University Medical Center, Nashville, United States of America
5Pathology and Molecular Medicine, Queen's University, Kingston, Canada
6Department Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, United States of America
Find articles by Rauh, M. in: PubMed | Google Scholar
1University of Florida College of Medicine, Gainesville, United States of America
2Queen's University, Kingston, Canada
3Queen's University, Kingston, United States of America
4Vanderbilt University Medical Center, Nashville, United States of America
5Pathology and Molecular Medicine, Queen's University, Kingston, Canada
6Department Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, United States of America
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Published September 30, 2025 - More info
Copyright © 2025, Yan et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)