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ResearchIn-Press PreviewHepatologyMetabolism
Open Access | 
10.1172/JCI194148
Targeting the E3 ubiquitin ligase RNF10 ameliorates metabolic dysfunction-associated steatohepatitis in mice
Chunyuan Du,1 Yinliang Zhang,1 Hongkai Chang,2 Chaofan Xu,1 Sufang Sheng,3 Ke Xu,1 Wei Qiao,1 Yanjun Liu,4 Tongtong Zhang,4 Yong Gao,5 Peng Li,2 and Yongsheng Chang1
1Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China
2Department of Gastroenterology, Capital Medical University, Beijing, China
3Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, Weifang, China
4Department of General Surgery, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, China
5Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China
Find articles by Du, C. in: PubMed | Google Scholar
1Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China
2Department of Gastroenterology, Capital Medical University, Beijing, China
3Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, Weifang, China
4Department of General Surgery, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, China
5Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China
Find articles by Zhang, Y. in: PubMed | Google Scholar
1Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China
2Department of Gastroenterology, Capital Medical University, Beijing, China
3Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, Weifang, China
4Department of General Surgery, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, China
5Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China
Find articles by Chang, H. in: PubMed | Google Scholar
1Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China
2Department of Gastroenterology, Capital Medical University, Beijing, China
3Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, Weifang, China
4Department of General Surgery, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, China
5Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China
Find articles by Xu, C. in: PubMed | Google Scholar
1Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China
2Department of Gastroenterology, Capital Medical University, Beijing, China
3Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, Weifang, China
4Department of General Surgery, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, China
5Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China
Find articles by Sheng, S. in: PubMed | Google Scholar
1Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China
2Department of Gastroenterology, Capital Medical University, Beijing, China
3Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, Weifang, China
4Department of General Surgery, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, China
5Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China
Find articles by Xu, K. in: PubMed | Google Scholar
1Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China
2Department of Gastroenterology, Capital Medical University, Beijing, China
3Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, Weifang, China
4Department of General Surgery, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, China
5Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China
Find articles by Qiao, W. in: PubMed | Google Scholar
1Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China
2Department of Gastroenterology, Capital Medical University, Beijing, China
3Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, Weifang, China
4Department of General Surgery, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, China
5Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China
Find articles by Liu, Y. in: PubMed | Google Scholar
1Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China
2Department of Gastroenterology, Capital Medical University, Beijing, China
3Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, Weifang, China
4Department of General Surgery, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, China
5Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China
Find articles by Zhang, T. in: PubMed | Google Scholar
1Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China
2Department of Gastroenterology, Capital Medical University, Beijing, China
3Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, Weifang, China
4Department of General Surgery, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, China
5Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China
Find articles by Gao, Y. in: PubMed | Google Scholar
1Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China
2Department of Gastroenterology, Capital Medical University, Beijing, China
3Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, Weifang, China
4Department of General Surgery, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, China
5Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China
Find articles by Li, P. in: PubMed | Google Scholar
1Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China
2Department of Gastroenterology, Capital Medical University, Beijing, China
3Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, Weifang, China
4Department of General Surgery, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, China
5Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China
Find articles by Chang, Y. in: PubMed | Google Scholar
Published August 11, 2026 - More info
Copyright © 2026, Du et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)