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ResearchIn-Press PreviewCell biologyImmunologyOncology Open Access | 10.1172/JCI187371

Aggressive B-cell lymphomas retain ATR-dependent determinants of T-cell exclusion from the Germinal Center Dark Zone

Valeria Cancila,1 Giorgio Bertolazzi,2 Allison S.Y. Chan,3 Giovanni Medico,4 Giulia Bastianello,5 Gaia Morello,1 Daniel Paysan,6 Clemence Lai,3 Liang Hong,3 Girija Shenoy,3 Patrick W. Jaynes,3 Giovanna Schiavoni,7 Fabrizio Mattei,7 Silvia Piconese,8 Maria V. Revuelta,9 Francesco Noto,7 Luca Businaro,10 Adele De Ninno,10 Ilenia Cammarata,11 Fabio Pagni,12 Saradha Venkatachalapathy,13 Sabina Sangaletti,14 Arianna Di Napoli,15 Giada Cicio,16 Davide Vacca,1 Silvia Lonardi,17 Luisa Lorenzi,17 Andrés J.M. Ferreri,18 Beatrice Belmonte,19 Min Liu,20 Manikandan Lakshmanan,21 Michelle S.N. Ong,21 Biyan Zhang,22 Tingyi See,22 Kong-Peng Lam,22 Gabriele Varano,23 Mario P. Colombo,14 Silvio Bicciato,24 Giorgio Inghirami,4 Leandro Cerchietti,25 Maurilio Ponzoni,26 Roberta Zappasodi,27 Evelyn Metzger,28 Joseph Beechem,28 Fabio Facchetti,17 Marco Foiani,5 Stefano Casola,23 Anand D. Jeyasekharan,3 and Claudio Tripodo16

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Cancila, V. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Bertolazzi, G. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Chan, A. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Medico, G. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Bastianello, G. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Morello, G. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Paysan, D. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Lai, C. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Hong, L. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Shenoy, G. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Jaynes, P. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Schiavoni, G. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Mattei, F. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Piconese, S. in: PubMed | Google Scholar |

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Revuelta, M. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Noto, F. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Businaro, L. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by De Ninno, A. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Cammarata, I. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Pagni, F. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Venkatachalapathy, S. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Sangaletti, S. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Di Napoli, A. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Cicio, G. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Vacca, D. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Lonardi, S. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Lorenzi, L. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Ferreri, A. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Belmonte, B. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Liu, M. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Lakshmanan, M. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Ong, M. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Zhang, B. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by See, T. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Lam, K. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Varano, G. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Colombo, M. in: PubMed | Google Scholar |

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Bicciato, S. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Inghirami, G. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Cerchietti, L. in: PubMed | Google Scholar |

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Ponzoni, M. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Zappasodi, R. in: PubMed | Google Scholar |

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Metzger, E. in: PubMed | Google Scholar |

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Beechem, J. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Facchetti, F. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Foiani, M. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Casola, S. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

Find articles by Jeyasekharan, A. in: PubMed | Google Scholar

1Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy

2Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

4Division of Hematopathology, Department of Pathology and Laboratory Medicin, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

5Genome Integrity Lab, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

6Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

8Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular, Sapienza University of Rome, Rome, Italy

9Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, United States of America

10Italian National Research Council, Institute for Photonics and Nanotechnologies, Rome, Italy

11Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

12Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo, University of Milano - Bicocca, Milan, Italy

13Laboratory for Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland

14Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

15Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy

16Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

17Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and, University of Brescia, Brescia, Italy

18Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19Tumor Immunology Unit, Department of Health Science, University of Palermo, Palermo, Italy

20Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

21Biopharma Innovations and Solutions, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore

22Singapore Immunology Network (A*STAR), Singapore, Singapore

23Genetics of B Cells and Lymphoma Unit, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy

24Department of Molecular Medicine, University of Padova, Padova, Italy

25Division of Hematology and Oncology, Medicine Department, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, United States of America

26Vita-Salute San Raffaele University, Milan, Italy

27Department of Medicine, Weill Cornell Medicine, New York, United States of America

28Bruker Spatial Biology, Seattle, United States of America

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Published July 17, 2025 - More info

J Clin Invest. https://doi.org/10.1172/JCI187371.
Copyright © 2025, Cancila et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Published July 17, 2025 - Version history
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Abstract

The germinal center (GC) dark zone (DZ) and light zone (LZ) represent distinct anatomical regions in lymphoid tissue where B-cell proliferation, immunoglobulin diversification, and selection are coordinated. Diffuse Large B-cell Lymphomas (DLBCL) with DZ-like gene expression profiles exhibit poor outcomes, though reasons are unclear and are not directly related to proliferation. Physiological DZs exhibit an exclusion of T-cells, prompting exploration for whether T-cell paucity contributes to DZ-like DLBCL. We used spatial transcriptomic approaches to achieve higher resolution of T-cell spatial heterogeneity in the GC and to derive potential pathways that underlie T-cell exclusion. We showed that T-cell exclusion from the DZ was linked to DNA damage response (DDR) and chromatin compaction molecular features characterizing the spatial DZ signature, and that these programs were independent of AID deaminase activity. As ATR is a key regulator of DDR, we tested its role in the T-cell inhibitory DZ transcriptional imprint. ATR inhibition reversed not only the DZ transcriptional signature but also DZ T-cell exclusion in DZ-like DLBCL in vitro microfluidic models and in in vivo samples of murine lymphoid tissue. These findings highlight that ATR activity underpins a physiological scenario of immune silencing. ATR inhibition may reverse the immune silent state and enhance T-cell based immunotherapy in aggressive lymphomas with GC DZ-like characteristics.

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